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Javier García-Bermúdez


Ph.D in Biochemistry, Molecular Biology, Biomedicine and Biotechnology, Universidad Autonoma of Madrid, 2015

Current position

Postdoctoral Associate in Laboratory of Metabolic Regulation and Genetics, Rockefeller University, New York, U.S.A


  1. Garcia-Bermudez, J. and Cuezva, J. M. (2016). The ATPase Inhibitory Factor 1 (IF1): A master regulator of energy metabolism and of cell survival. Biochim Biophys Acta 1857(8): 1167-1182.

  2. Santacatterina, F., Sanchez-Cenizo, L., Formentini, L., Mobasher, M. A., Casas, E., Rueda, C. B., Martinez-Reyes, I., Nunez de Arenas, C., Garcia-Bermudez, J., Zapata, J. M., Sanchez-Arago, M., Satrustegui, J., Valverde, A. M. and Cuezva, J. M. (2016). Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state. Oncotarget 7(1): 490-508.

  3. Garcia-Bermudez, J., Sanchez-Arago, M., Soldevilla, B., Del Arco, A., Nuevo-Tapioles, C. and Cuezva, J. M. (2015). PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H(+)-ATP Synthase. Cell Rep 12(12): 2143-2155.

  4. Sanchez-Arago, M., Garcia-Bermudez, J., Martinez-Reyes, I., Santacatterina, F. and Cuezva, J. M. (2013). Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells. EMBO Rep 14(7): 638-644.

  5. Sanchez-Arago, M., Formentini, L., Martinez-Reyes, I., Garcia-Bermudez, J., Santacatterina, F., Sanchez-Cenizo, L., Willers, I. M., Aldea, M., Najera, L., Juarranz, A., Lopez, E. C., Clofent, J., Navarro, C., Espinosa, E. and Cuezva, J. M. (2013). Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers. Oncogenesis 2: e46.

  6. Sanchez-Arago, M., Formentini, L., Garcia-Bermudez, J. and Cuezva, J. M. (2012). IF1 reprograms energy metabolism and signals the oncogenic phenotype in cancer. Cell Cycle 11(16): 2963-2964.

Protocols by Javier García-Bermúdez
  1. Determination of the H+-ATP Synthase and Hydrolytic Activities