Thibaud T. Renault

Education

Ph. D. in Biochemistry, CNRS/Université de Bordeaux 2, Bordeaux, France.

Current position

Postdoctoral Fellow
Helmholtz Center for Infection Research, Braunschweig, Germany
Max Planck Institute for Infection Biology, Berlin, Germany

Publications(since 2010)

1. Renault, T. T., Dejean, L. M. and Manon, S. (2016). A brewing understanding of the regulation of Bax function by Bcl-xL and Bcl-2. Mech Ageing Dev.
2. Simonyan, L., Renault, T. T., da Costa Novais, M. J., Sousa, M. J., Corte-Real, M., Camougrand, N., Gonzalez, C. and Manon, S. (2016). Regulation of Bax/mitochondria interaction by AKT. FEBS Lett 590(1): 13-21.
3. Renault, T. T., Teijido, O., Missire, F., Ganesan, Y. T., Velours, G., Arokium, H., Beaumatin, F., Llanos, R., Athane, A., Camougrand, N., Priault, M., Antonsson, B., Dejean, L. M. and Manon, S. (2015). Bcl-xL stimulates Bax relocation to mitochondria and primes cells to ABT-737. Int J Biochem Cell Biol 64: 136-146.
4. Serasinghe, M. N., Wieder, S. Y., Renault, T. T., Elkholi, R., Asciolla, J. J., Yao, J. L., Jabado, O., Hoehn, K., Kageyama, Y., Sesaki, H. and Chipuk, J. E. (2015). Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors. Mol Cell 57(3): 521-536.
5. Renault, T. T., Floros, K. V., Elkholi, R., Corrigan, K. A., Kushnareva, Y., Wieder, S. Y., Lindtner, C., Serasinghe, M. N., Asciolla, J. J., Buettner, C., Newmeyer, D. D. and Chipuk, J. E. (2015). Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. Mol Cell 57(1): 69-82.
6. Elkholi, R., Renault, T. T., Serasinghe, M. N. and Chipuk, J. E. (2014). Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy? Cancer Metab 2: 16.
7. Renault, T. T., Elkholi, R., Bharti, A. and Chipuk, J. E. (2014). B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins. J Biol Chem 289(38): 26481-26491.
8. Renault, T. T. and Chipuk, J. E. (2014). Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis. Chem Biol 21(1): 114-123.
9. Renault, T. T. and Chipuk, J. E. (2013). Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis. Commun Integr Biol 6(2): e22872.
10. Renault, T. T., Floros, K. V. and Chipuk, J. E. (2013). BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods 61(2): 146-155.
11. Renault, T. T. and Chipuk, J. E. (2013). Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci 1285: 59-79.
12. Asciolla, J. J., Renault, T. T. and Chipuk, J. E. (2012). Examining BCL-2 family function with large unilamellar vesicles. J Vis Exp(68).
13. Renault, T. T., Teijido, O., Antonsson, B., Dejean, L. M. and Manon, S. (2013). Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x(L): keep your friends close but your enemies closer. Int J Biochem Cell Biol 45(1): 64-67.
14. Renault, T. T., Grandier-Vazeille, X., Arokium, H., Velours, G., Camougrand, N., Priault, M., Teijido, O., Dejean, L. M. and Manon, S. (2012). The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast. FEBS Lett 586(2): 116-121.
15. Renault, T. T. and Manon, S. (2011). Bax: Addressed to kill. Biochimie 93(9): 1379-1391.

Protocols by Thibaud T. Renault

1. Mouse Liver Mitochondria Isolation, Size Fractionation, and Real-time MOMP Measurement