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Maria Regina D’Império Lima


Ph.D. in Parasitology Program at USP, 1992

Current position

Associate Professor: Department of Immunology at USP


  1. Borges da Silva, H., Fonseca, R., Cassado Ados, A., Machado de Salles, E., de Menezes, M. N., Langhorne, J., Perez, K. R., Cuccovia, I. M., Ryffel, B., Barreto, V. M., Marinho, C. R., Boscardin, S. B., Alvarez, J. M., D'Imperio-Lima, M. R. and Tadokoro, C. E. (2015). In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria. PLoS Pathog 11(2): e1004598.

  2. Amaral, E. P., Ribeiro, S. C., Lanes, V. R., Almeida, F. M., de Andrade, M. R., Bomfim, C. C., Salles, E. M., Bortoluci, K. R., Coutinho-Silva, R., Hirata, M. H., Alvarez, J. M., Lasunskaia, E. B. and D'Imperio-Lima, M. R. (2014). Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis. PLoS Pathog 10(7): e1004188.

  3. Lage, S. L., Buzzo, C. L., Amaral, E. P., Matteucci, K. C., Massis, L. M., Icimoto, M. Y., Carmona, A. K., D'Imperio Lima, M. R., Rodrigues, M. M., Ferreira, L. C., Amarante-Mendes, G. P. and Bortoluci, K. R. (2013). Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses. Proc Natl Acad Sci U S A 110(35): E3321-3330.

  4. da Silva, H. B., de Salles, E. M., Panatieri, R. H., Boscardin, S. B., Rodriguez-Malaga, S. M., Alvarez, J. M. and D'Imperio Lima, M. R. (2013). IFN-gamma-induced priming maintains long-term strain-transcending immunity against blood-stage Plasmodium chabaudi malaria. J Immunol 191(10): 5160-5169.

  5. Freitas do Rosario, A. P., Muxel, S. M., Rodriguez-Malaga, S. M., Sardinha, L. R., Zago, C. A., Castillo-Mendez, S. I., Alvarez, J. M. and D'Imperio Lima, M. R. (2008). Gradual decline in malaria-specific memory T cell responses leads to failure to maintain long-term protective immunity to Plasmodium chabaudi AS despite persistence of B cell memory and circulating antibody. J Immunol 181(12): 8344-8355.

  6. Elias, R. M., Sardinha, L. R., Bastos, K. R., Zago, C. A., da Silva, A. P., Alvarez, J. M. and Lima, M. R. (2005). Role of CD28 in polyclonal and specific T and B cell responses required for protection against blood stage malaria. J Immunol 174(2): 790-799.

  7. Bastos, K. R., Marinho, C. R., Barboza, R., Russo, M., Alvarez, J. M. and D'Imperio Lima, M. R. (2004). What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells? Microbes Infect 6(6): 630-636.

  8. Bastos, K. R., Alvarez, J. M., Marinho, C. R., Rizzo, L. V. and Lima, M. R. (2002). Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile. J Leukoc Biol 71(2): 271-278.

  9. d'Imperio Lima, M. R., Eisen, H., Minoprio, P., Joskowicz, M. and Coutinho, A. (1986). Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas' disease. J Immunol 137(1): 353-356.

  10. D'Imperio Lima, M. R., Joskowicz, M., Coutinho, A., Kipnis, T. and Eisen, H. (1985). Very large and isotypically atypical polyclonal plaque-forming cell responses in mice infected with Trypanosoma cruzi. Eur J Immunol 15(2): 201-203.