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Shiaw-Yih Lin

Education

Ph.D in Cancer Biology, The University of Texas MD Anderson Cancer Center, 1999

Current position

Professor, Department of Systems Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Deputy Department Chair, Department of Systems Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX
Chief, Section of Systems and Translational DNA Repair, Department of Systems Biology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Publications

  1. Mo, W., Liu, Q., Lin, C. C., Dai, H., Peng, Y., Liang, Y., Peng, G., Meric-Bernstam, F., Mills, G. B., Li, K. and Lin, S. Y. (2016). mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. Clin Cancer Res 22(7): 1699-1712.

  2. Kim, J. L., Ha, G. H., Campo, L., Denning, M. F., Patel, T. B., Osipo, C., Lin, S. Y. and Breuer, E. K. (2015). The role of Rak in the regulation of stability and function of BRCA1. Oncotarget.

  3. Jiang, Y., Qian, X., Shen, J., Wang, Y., Li, X., Liu, R., Xia, Y., Chen, Q., Peng, G., Lin, S. Y. and Lu, Z. (2015). Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol 17(9): 1158-1168.

  4. Liang, Y., Gao, H., Lin, S. Y., Goss, J. A., Du, C. and Li, K. (2015). Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene 34(33): 4368-4378.

  5. Lee, H. J., Lan, L., Peng, G., Chang, W. C., Hsu, M. C., Wang, Y. N., Cheng, C. C., Wei, L., Nakajima, S., Chang, S. S., Liao, H. W., Chen, C. H., Lavin, M., Ang, K. K., Lin, S. Y. and Hung, M. C. (2015). Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25(2): 225-236.

  6. Peng, Y., Dai, H., Wang, E., Lin, C. C., Mo, W., Peng, G. and Lin, S. Y. (2015). TUSC4 functions as a tumor suppressor by regulating BRCA1 stability. Cancer Res 75(2): 378-386.

  7. Gong, L., Govan, J. M., Evans, E. B., Dai, H., Wang, E., Lee, S. W., Lin, H. K., Lazar, A. J., Mills, G. B. and Lin, S. Y. (2015). Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. Cell Cycle 14(14): 2323-2332.

  8. Peng, G., Chun-Jen Lin, C., Mo, W., Dai, H., Park, Y. Y., Kim, S. M., Peng, Y., Mo, Q., Siwko, S., Hu, R., Lee, J. S., Hennessy, B., Hanash, S., Mills, G. B. and Lin, S. Y. (2014). Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 5: 3361.

  9. Zhang, B., Wang, E., Dai, H., Hu, R., Liang, Y., Li, K., Wang, G., Peng, G. and Lin, S. Y. (2013). BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer. Carcinogenesis 34(10): 2271-2280.

  10. Tian, F., Sharma, S., Zou, J., Lin, S. Y., Wang, B., Rezvani, K., Wang, H., Parvin, J. D., Ludwig, T., Canman, C. E. and Zhang, D. (2013). BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A 110(33): 13558-13563.

  11. Meng, L., Lin, T., Peng, G., Hsu, J. K., Lee, S., Lin, S. Y. and Tsai, R. Y. (2013). Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A 110(28): 11415-11420.

  12. Hu, R., Wang, E., Peng, G., Dai, H. and Lin, S. Y. (2013). Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle 12(13): 2033-2041.

  13. Trinh, B. Q., Ko, S. Y., Barengo, N., Lin, S. Y. and Naora, H. (2013). Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs. Cancer Res 73(2): 1000-1010.

  14. Park, Y. Y., Jung, S. Y., Jennings, N. B., Rodriguez-Aguayo, C., Peng, G., Lee, S. R., Kim, S. B., Kim, K., Leem, S. H., Lin, S. Y., Lopez-Berestein, G., Sood, A. K. and Lee, J. S. (2012). FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis 33(10): 1843-1853.

  15. Peng, G., Dai, H., Zhang, W., Hsieh, H. J., Pan, M. R., Park, Y. Y., Tsai, R. Y., Bedrosian, I., Lee, J. S., Ira, G. and Lin, S. Y. (2012). Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection. Cancer Res 72(11): 2802-2813.

  16. Pan, M. R., Hsieh, H. J., Dai, H., Hung, W. C., Li, K., Peng, G. and Lin, S. Y. (2012). Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment. J Biol Chem 287(9): 6764-6772.

  17. Zhang, W., Peng, G., Lin, S. Y. and Zhang, P. (2011). DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem 286(41): 35899-35905.

  18. Hu, R., Peng, G., Dai, H., Breuer, E. K., Stemke-Hale, K., Li, K., Gonzalez-Angulo, A. M., Mills, G. B. and Lin, S. Y. (2011). ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res 71(20): 6524-6534.

  19. Pan, M. R., Peng, G., Hung, W. C. and Lin, S. Y. (2011). Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem 286(32): 28599-28607.

  20. Seviour, E. G. and Lin, S. Y. (2010). The DNA damage response: Balancing the scale between cancer and ageing. Aging (Albany NY) 2(12): 900-907.

  21. Tian, L., Peng, G., Parant, J. M., Leventaki, V., Drakos, E., Zhang, Q., Parker-Thornburg, J., Shackleford, T. J., Dai, H., Lin, S. Y., Lozano, G., Rassidakis, G. Z. and Claret, F. X. (2010). Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene 29(46): 6125-6137.

  22. Ishiguro, T., Avila, H., Lin, S. Y., Nakamura, T., Yamamoto, M. and Boyd, D. D. (2010). Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases. Br J Cancer 102(4): 774-782.

  23. Liang, Y., Gao, H., Lin, S. Y., Peng, G., Huang, X., Zhang, P., Goss, J. A., Brunicardi, F. C., Multani, A. S., Chang, S. and Li, K. (2010). BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet 6(1): e1000826.

  24. Liang, Y., Gao, H., Lin, S. Y., Goss, J. A., Brunicardi, F. C. and Li, K. (2010). siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. PLoS One 5(9): e12860.

  25. Peng, G., Yim, E. K., Dai, H., Jackson, A. P., Burgt, I., Pan, M. R., Hu, R., Li, K. and Lin, S. Y. (2009). BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 11(7): 865-872.

  26. Yim, E. K., Peng, G., Dai, H., Hu, R., Li, K., Lu, Y., Mills, G. B., Meric-Bernstam, F., Hennessy, B. T., Craven, R. J. and Lin, S. Y. (2009). Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15(4): 304-314.

  27. Kim, H., Lee, O. H., Xin, H., Chen, L. Y., Qin, J., Chae, H. K., Lin, S. Y., Safari, A., Liu, D. and Songyang, Z. (2009). TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol 16(4): 372-379.

  28. Rai, R., Phadnis, A., Haralkar, S., Badwe, R. A., Dai, H., Li, K. and Lin, S. Y. (2008). Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle 7(14): 2225-2233.

  29. Ding, Z., Liang, J., Lu, Y., Yu, Q., Songyang, Z., Lin, S. Y. and Mills, G. B. (2006). A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A 103(41): 15014-15019.

  30. Rai, R., Dai, H., Multani, A. S., Li, K., Chin, K., Gray, J., Lahad, J. P., Liang, J., Mills, G. B., Meric-Bernstam, F. and Lin, S. Y. (2006). BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 10(2): 145-157.

  31. Lin, S. Y., Rai, R., Li, K., Xu, Z. X. and Elledge, S. J. (2005). BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A 102(42): 15105-15109.

Protocols by Shiaw-Yih Lin
  1. Ubiquitination Assay for Mammalian Cells