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Sandhya S. Visweswariah

Education

Ph.D., Department of Biochemistry, Indian Institute of Science, 1987

Current position

Professor and Chair, Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
Co-Chair, Centre for Biosystems Science and Engineering, Indian Institute of Science, Bangalore, India
Adjunct Professor, Faculty of Medicine and Dentistry, University of Bergen, Norway

Publications (since 2005)

  1. Visweswariah, S. S. and Busby, S. J. (2015). Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones. Trends Microbiol 23(8): 463-467.

  2. Muller, T., Rasool, I., Heinz-Erian, P., Mildenberger, E., Hulstrunk, C., Muller, A., Michaud, L., Koot, B. G., Ballauff, A., Vodopiutz, J., Rosipal, S., Petersen, B. S., Franke, A., Fuchs, I., Witt, H., Zoller, H., Janecke, A. R. and Visweswariah, S. S. (2015). Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C. Gut.

  3. Matange, N., Podobnik, M. and Visweswariah, S. S. (2015). Metallophosphoesterases: structural fidelity with functional promiscuity. Biochem J 467(2): 201-216.

  4. Kumar, S., Matange, N., Umapathy, S. and Visweswariah, S. S. (2015). Linking carbon metabolism to carotenoid production in mycobacteria using Raman spectroscopy. FEMS Microbiol Lett 362(3): 1-6.

  5. Biswas, K. H., Badireddy, S., Rajendran, A., Anand, G. S. and Visweswariah, S. S. (2015). Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2. PeerJ 3: e882.

  6. Banerjee, A., Adolph, R. S., Gopalakrishnapai, J., Kleinboelting, S., Emmerich, C., Steegborn, C. and Visweswariah, S. S. (2015). A universal stress protein (USP) in mycobacteria binds cAMP. J Biol Chem 290(20): 12731-12743.

  7. Sharma, R., Zaveri, A., Gopalakrishnapai, J., Srinath, T., Varshney, U. and Visweswariah, S. S. (2014). Paralogous cAMP receptor proteins in Mycobacterium smegmatis show biochemical and functional divergence. Biochemistry 53(49): 7765-7776.

  8. Podobnik, M., Siddiqui, N., Rebolj, K., Nambi, S., Merzel, F. and Visweswariah, S. S. (2014). Allostery and conformational dynamics in cAMP-binding acyltransferases. J Biol Chem 289(23): 16588-16600.

  9. Matange, N., Podobnik, M. and Visweswariah, S. S. (2014). The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell. J Biol Chem 289(32): 22470-22481.

  10. Kahramanoglou, C., Cortes, T., Matange, N., Hunt, D. M., Visweswariah, S. S., Young, D. B. and Buxton, R. S. (2014). Genomic mapping of cAMP receptor protein (CRP Mt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor. Nucleic Acids Res 42(13): 8320-8329.

  11. Basu, N., Saha, S., Khan, I., Ramachandra, S. G. and Visweswariah, S. S. (2014). Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. J Biol Chem 289(1): 581-593.

  12. Nambi, S., Gupta, K., Bhattacharyya, M., Ramakrishnan, P., Ravikumar, V., Siddiqui, N., Thomas, A. T. and Visweswariah, S. S. (2013). Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism. J Biol Chem 288(20): 14114-14124.

  13. Matange, N., Hunt, D. M., Buxton, R. S. and Visweswariah, S. S. (2013). Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response. Tuberculosis (Edinb) 93(5): 492-500.

  14. Arshad, N. and Visweswariah, S. S. (2013). Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter. Wiley Interdiscip Rev Syst Biol Med 5(4): 409-424.

  15. Arshad, N., Ballal, S. and Visweswariah, S. S. (2013). Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36. J Biol Chem 288(6): 3907-3917.

  16. Nambi, S., Badireddy, S., Visweswariah, S. S. and Anand, G. S. (2012). Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases. J Biol Chem 287(22): 18115-18129.

  17. Fiskerstrand, T., Arshad, N., Haukanes, B. I., Tronstad, R. R., Pham, K. D., Johansson, S., Havik, B., Tonder, S. L., Levy, S. E., Brackman, D., Boman, H., Biswas, K. H., Apold, J., Hovdenak, N., Visweswariah, S. S. and Knappskog, P. M. (2012). Familial diarrhea syndrome caused by an activating GUCY2C mutation. N Engl J Med 366(17): 1586-1595.

  18. Arshad, N. and Visweswariah, S. S. (2012). The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis. FEBS Lett 586(18): 2835-2840.

  19. Dermol, U., Janardan, V., Tyagi, R., Visweswariah, S. S. and Podobnik, M. (2011). Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J Mol Biol 412(3): 481-494.

  20. Chakraborti, P. K., Matange, N., Nandicoori, V. K., Singh, Y., Tyagi, J. S. and Visweswariah, S. S. (2011). Signalling mechanisms in Mycobacteria. Tuberculosis (Edinb) 91(5): 432-440.

  21. Biswas, K. H. and Visweswariah, S. S. (2011). Distinct allostery induced in the cyclic GMP-binding, cyclic GMP-specific phosphodiesterase (PDE5) by cyclic GMP, sildenafil, and metal ions. J Biol Chem 286(10): 8545-8554.

  22. Basu, N. and Visweswariah, S. S. (2011). Defying the stereotype: non-canonical roles of the Peptide hormones guanylin and uroguanylin. Front Endocrinol (Lausanne) 2: 14.

  23. Nambi, S., Basu, N. and Visweswariah, S. S. (2010). cAMP-regulated protein lysine acetylases in mycobacteria. J Biol Chem 285(32): 24313-24323.

  24. Basu, N., Arshad, N. and Visweswariah, S. S. (2010). Receptor guanylyl cyclase C (GC-C): regulation and signal transduction. Mol Cell Biochem 334(1-2): 67-80.

  25. Tyagi, R., Shenoy, A. R. and Visweswariah, S. S. (2009). Characterization of an evolutionarily conserved metallophosphoesterase that is expressed in the fetal brain and associated with the WAGR syndrome. J Biol Chem 284(8): 5217-5228.

  26. Sawarkar, R., Visweswariah, S. S., Nellen, W. and Nanjundiah, V. (2009). Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum. J Mol Biol 391(5): 833-848.

  27. Saha, S., Biswas, K. H., Kondapalli, C., Isloor, N. and Visweswariah, S. S. (2009). The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C. J Biol Chem 284(40): 27135-27145.

  28. Podobnik, M., Tyagi, R., Matange, N., Dermol, U., Gupta, A. K., Mattoo, R., Seshadri, K. and Visweswariah, S. S. (2009). A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. J Biol Chem 284(47): 32846-32857.

  29. Biswas, K. H., Shenoy, A. R., Dutta, A. and Visweswariah, S. S. (2009). The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. J Mol Evol 68(6): 587-602.

  30. Basu, N., Bhandari, R., Natarajan, V. T. and Visweswariah, S. S. (2009). Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis. Mol Cell Biol 29(19): 5277-5289.

  31. Dass, B. K., Sharma, R., Shenoy, A. R., Mattoo, R. and Visweswariah, S. S. (2008). Cyclic AMP in mycobacteria: characterization and functional role of the Rv1647 ortholog in Mycobacterium smegmatis. J Bacteriol 190(11): 3824-3834.

  32. Biswas, K. H., Sopory, S. and Visweswariah, S. S. (2008). The GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) is a sensor and a sink for cGMP. Biochemistry 47(11): 3534-3543.

  33. Shenoy, A. R., Capuder, M., Draskovic, P., Lamba, D., Visweswariah, S. S. and Podobnik, M. (2007). Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. J Mol Biol 365(1): 211-225.

  34. Shenoy, A. R. and Visweswariah, S. S. (2006). Mycobacterial adenylyl cyclases: biochemical diversity and structural plasticity. FEBS Lett 580(14): 3344-3352.

  35. Shenoy, A. R. and Visweswariah, S. S. (2006). New messages from old messengers: cAMP and mycobacteria. Trends Microbiol 14(12): 543-550.

  36. Ketkar, A. D., Shenoy, A. R., Ramagopal, U. A., Visweswariah, S. S. and Suguna, K. (2006). A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis. J Mol Biol 356(4): 904-916.

  37. Jaleel, M., Saha, S., Shenoy, A. R. and Visweswariah, S. S. (2006). The kinase homology domain of receptor guanylyl cyclase C: ATP binding and identification of an adenine nucleotide sensitive site. Biochemistry 45(6): 1888-1898.

  38. Shenoy, A. R., Srinivas, A., Mahalingam, M. and Visweswariah, S. S. (2005). An adenylyl cyclase pseudogene in Mycobacterium tuberculosis has a functional ortholog in Mycobacterium avium. Biochimie 87(6): 557-563.

  39. Shenoy, A. R., Sreenath, N. P., Mahalingam, M. and Visweswariah, S. S. (2005). Characterization of phylogenetically distant members of the adenylate cyclase family from mycobacteria: Rv1647 from Mycobacterium tuberculosis and its orthologue ML1399 from M. leprae. Biochem J 387(Pt 2): 541-551.

  40. Shenoy, A. R., Sreenath, N., Podobnik, M., Kovacevic, M. and Visweswariah, S. S. (2005). The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. Biochemistry 44(48): 15695-15704.

Protocols by Sandhya S. Visweswariah
  1. Separation of Free and Bound cAMP in Mycobacteria