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Julieta Alfonso


PhD, Molecular Biology and Biotechnology Program, IIB-UNSAM, Argentina, 2005.

Current position

Junior Group Leader, Department of Clinical Neurobiology at the German Cancer Research Center (DKFZ) and the Medical Faculty of the Heidelberg University, Heidelberg, Germany.


  1. Hoffmann, A., Pfeil, J., Alfonso, J., Kurz, F. T., Sahm, F., Heiland, S., Monyer, H., Bendszus, M., Mueller, A. K., Helluy, X. and Pham, M. (2016). Experimental Cerebral Malaria Spreads along the Rostral Migratory Stream. PLoS Pathog 12(3): e1005470.

  2. Alfonso, J., Penkert, H., Duman, C., Zuccotti, A. and Monyer, H. (2015). Downregulation of Sphingosine 1-Phosphate Receptor 1 Promotes the Switch from Tangential to Radial Migration in the OB. J Neurosci 35(40): 13659-13672.

  3. Khodosevich, K., Alfonso, J. and Monyer, H. (2013). Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts. Mech Dev 130(6-8): 424-432.

  4. Alfonso, J., Le Magueresse, C., Zuccotti, A., Khodosevich, K. and Monyer, H. (2012). Diazepam binding inhibitor promotes progenitor proliferation in the postnatal SVZ by reducing GABA signaling. Cell Stem Cell 10(1): 76-87.

  5. Le Magueresse, C., Alfonso, J., Bark, C., Eliava, M., Khrulev, S. and Monyer, H. (2012). Subventricular zone-derived neuroblasts use vasculature as a scaffold to migrate radially to the cortex in neonatal mice. Cereb Cortex 22(10): 2285-2296.

  6. Le Magueresse, C., Alfonso, J., Khodosevich, K., Arroyo Martin, A. A., Bark, C. and Monyer, H. (2011). "Small axonless neurons": postnatally generated neocortical interneurons with delayed functional maturation. J Neurosci 31(46): 16731-16747.

  7. Fuchsova, B., Fernandez, M. E., Alfonso, J. and Frasch, A. C. (2009). Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. J Biol Chem 284(46): 32075-32088.

  8. Fernandez, M. E., Alfonso, J., Brocco, M. A. and Frasch, A. C. (2010). Conserved cellular function and stress-mediated regulation among members of the proteolipid protein family. J Neurosci Res 88(6): 1298-1308.

  9. Inta, D., Alfonso, J., von Engelhardt, J., Kreuzberg, M. M., Meyer, A. H., van Hooft, J. A. and Monyer, H. (2008). Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone. Proc Natl Acad Sci U S A 105(52): 20994-20999.

  10. Alfonso, J., Frick, L. R., Silberman, D. M., Palumbo, M. L., Genaro, A. M. and Frasch, A. C. (2006). Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments. Biol Psychiatry 59(3): 244-251.

  11. Alfonso, J., Fernandez, M. E., Cooper, B., Flugge, G. and Frasch, A. C. (2005). The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation. Proc Natl Acad Sci U S A 102(47): 17196-17201.

  12. Alfonso, J., Frasch, A. C. and Flugge, G. (2005). Chronic stress, depression and antidepressants: effects on gene transcription in the hippocampus. Rev Neurosci 16(1): 43-56.

  13. Alfonso, J., Pollevick, G. D., Van Der Hart, M. G., Flugge, G., Fuchs, E. and Frasch, A. C. (2004). Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus. Eur J Neurosci 19(3): 659-666.

  14. Alfonso, J., Aguero, F., Sanchez, D. O., Flugge, G., Fuchs, E., Frasch, A. C. and Pollevick, G. D. (2004). Gene expression analysis in the hippocampal formation of tree shrews chronically treated with cortisol. J Neurosci Res 78(5): 702-710.

  15. Alfonso, J., Pollevick, G. D., Castensson, A., Jazin, E. and Frasch, A. C. (2002). Analysis of gene expression in the rat hippocampus using Real Time PCR reveals high inter-individual variation in mRNA expression levels. J Neurosci Res 67(2): 225-234.

  16. Buscaglia, C. A., Alfonso, J., Campetella, O. and Frasch, A. C. (1999). Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood. Blood 93(6): 2025-2032.

Protocols by Julieta Alfonso
  1. Mouse Subependymal Zone Explants Cultured on Primary Astrocytes