Welcome guest, Sign in

Home


Jan Münch

Education

Ph.D in Biology, Faculty of Natural Sciences, Friedrich Alexander University Erlangen Nürnberg, 2002

Current position

Professor in Molecular Virology, Institute of Molecular Virology, Ulm University Medical Centre, Ulm, Germany

Publications (since 2014)

  1. Bergman, P., Roan, N. R., Romling, U., Bevins, C. L. and Munch, J. (2016). Amyloid formation: functional friend or fearful foe? J Intern Med.
  2. Lavender, K. J., Gibbert, K., Peterson, K. E., Van Dis, E., Francois, S., Woods, T., Messer, R. J., Gawanbacht, A., Muller, J. A., Munch, J., Phillips, K., Race, B., Harper, M. S., Guo, K., Lee, E. J., Trilling, M., Hengel, H., Piehler, J., Verheyen, J., Wilson, C. C., Santiago, M. L., Hasenkrug, K. J. and Dittmer, U. (2016). Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo. J Virol 90(13): 6001-6013.
  3. Camus, C., Matusali, G., Bourry, O., Mahe, D., Aubry, F., Bujan, L., Pasquier, C., Massip, P., Ravel, C., Zirafi, O., Munch, J., Roan, N. R., Pineau, C. and Dejucq-Rainsford, N. (2016). Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection. AIDS 30(8): 1197-1208.
  4. Zirafi, O., Hermann, P. C. and Munch, J. (2016). Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4. J Leukoc Biol 99(6): 863-868.
  5. Muller, J. A., Zirafi, O., Roan, N. R., Lee, S. J. and Munch, J. (2016). Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant.
  6. Palesch, D., Wagner, J., Meid, A., Molenda, N., Sienczyk, M., Burkhardt, J., Munch, J., Prokop, L., Stevanovic, S., Westhoff, M. A., Halatsch, M. E., Wirtz, C. R., Zimecki, M. and Burster, T. (2016). Cathepsin G-mediated proteolytic degradation of MHC class I molecules to facilitate immune detection of human glioblastoma cells. Cancer Immunol Immunother 65(3): 283-291.
  7. Röcker, A., Kirchhoff, F. and Münch, J. (2016). Combating HIV: what does the human peptidome offer. Future Virology.vol. 11, No. 3, Pages 167-170
  8. Buske, C., Kirchhoff, F. and Munch, J. (2015). EPI-X4, a novel endogenous antagonist of CXCR4. Oncotarget 6(34): 35137-35138.
  9. Lump, E., Castellano, L. M., Meier, C., Seeliger, J., Erwin, N., Sperlich, B., Sturzel, C. M., Usmani, S., Hammond, R. M., von Einem, J., Gerold, G., Kreppel, F., Bravo-Rodriguez, K., Pietschmann, T., Holmes, V. M., Palesch, D., Zirafi, O., Weissman, D., Sowislok, A., Wettig, B., Heid, C., Kirchhoff, F., Weil, T., Klarner, F. G., Schrader, T., Bitan, G., Sanchez-Garcia, E., Winter, R., Shorter, J. and Munch, J. (2015). A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife 4.
  10. Roan, N. R. and Munch, J. (2015). Improving preclinical models of HIV microbicide efficacy. Trends Microbiol 23(8): 445-447.
  11. Zirafi, O., Kim, K. A., Standker, L., Mohr, K. B., Sauter, D., Heigele, A., Kluge, S. F., Wiercinska, E., Chudziak, D., Richter, R., Moepps, B., Gierschik, P., Vas, V., Geiger, H., Lamla, M., Weil, T., Burster, T., Zgraja, A., Daubeuf, F., Frossard, N., Hachet-Haas, M., Heunisch, F., Reichetzeder, C., Galzi, J. L., Perez-Castells, J., Canales-Mayordomo, A., Jimenez-Barbero, J., Gimenez-Gallego, G., Schneider, M., Shorter, J., Telenti, A., Hocher, B., Forssmann, W. G., Bonig, H., Kirchhoff, F. and Munch, J. (2015). Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep 11(5): 737-747.
  12. Mohr, K. B., Zirafi, O., Hennies, M., Wiese, S., Kirchhoff, F. and Munch, J. (2015). Sandwich enzyme-linked immunosorbent assay for the quantification of human serum albumin fragment 408-423 in bodily fluids. Anal Biochem 476: 29-35.
  13. Gross, A., Rodel, K., Kneidl, B., Donhauser, N., Mossl, M., Lump, E., Munch, J., Schmidt, B. and Eichler, J. (2015). Enhancement and induction of HIV-1 infection through an assembled peptide derived from the CD4 binding site of gp120. Chembiochem 16(3): 446-454.
  14. Yu, H., Khalid, M., Heigele, A., Schmokel, J., Usmani, S. M., van der Merwe, J., Munch, J., Silvestri, G. and Kirchhoff, F. (2015). Lentiviral Nef proteins manipulate T cells in a subset-specific manner. J Virol 89(4): 1986-2001.
  15. Zirafi, O., Kim, K. A., Roan, N. R., Kluge, S. F., Muller, J. A., Jiang, S., Mayer, B., Greene, W. C., Kirchhoff, F. and Munch, J. (2014). Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med 6(262): 262ra157.
  16. Munch, J., Standker, L., Forssmann, W. G. and Kirchhoff, F. (2014). Discovery of modulators of HIV-1 infection from the human peptidome. Nat Rev Microbiol 12(10): 715-722.
  17. Faissner, S., Ambrosius, B., Schanzmann, K., Grewe, B., Potthoff, A., Munch, J., Sure, U., Gramberg, T., Wittmann, S., Brockmeyer, N., Uberla, K., Gold, R., Grunwald, T. and Chan, A. (2014). Cytoplasmic HIV-RNA in monocytes determines microglial activation and neuronal cell death in HIV-associated neurodegeneration. Exp Neurol 261: 685-697.
  18. Mandell, M. A., Jain, A., Arko-Mensah, J., Chauhan, S., Kimura, T., Dinkins, C., Silvestri, G., Munch, J., Kirchhoff, F., Simonsen, A., Wei, Y., Levine, B., Johansen, T. and Deretic, V. (2014). TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev Cell 30(4): 394-409.
  19. Meier, C., Weil, T., Kirchhoff, F. and Munch, J. (2014). Peptide nanofibrils as enhancers of retroviral gene transfer. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6(5): 438-451.
  20. Roan, N. R., Liu, H., Usmani, S. M., Neidleman, J., Muller, J. A., Avila-Herrera, A., Gawanbacht, A., Zirafi, O., Chu, S., Dong, M., Kumar, S. T., Smith, J. F., Pollard, K. S., Fandrich, M., Kirchhoff, F., Munch, J., Witkowska, H. E. and Greene, W. C. (2014). Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol 88(13): 7221-7234.
  21. Usmani, S. M., Zirafi, O., Muller, J. A., Sandi-Monroy, N. L., Yadav, J. K., Meier, C., Weil, T., Roan, N. R., Greene, W. C., Walther, P., Nilsson, K. P., Hammarstrom, P., Wetzel, R., Pilcher, C. D., Gagsteiger, F., Fandrich, M., Kirchhoff, F. and Munch, J. (2014). Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun 5: 3508.
  22. Palesch, D., Khalid, M., Sturzel, C. M. and Munch, J. (2014). Prevention of contamination by xenotropic murine leukemia virus-related virus: susceptibility to alcohol-based disinfectants and environmental stability. Appl Environ Microbiol 80(8): 2617-2622.
  23. Heigele, A., Sauter, D., Munch, J. and Kirchhoff, F. (2014). HIV-1 accessory proteins: Nef. Methods Mol Biol 1087: 115-123.
Protocols by Jan Münch
  1. Reporter Assay for Semen-mediated Enhancement of HIV-1 Infection