Welcome guest, Login | Register

Home


Isabel L. Bazzocchi

Education

Ph.D in Pharmacy, Department of Organic Chemistry, University of La Laguna, 1986

Current position

Head of the QUIMIOPLAN research team at the Instituto Universitario de Bio-orgánica Antonio González, and Professor at the Department of Organic Chemistry, University of La Laguna, Tenerife, Spain

Publications (since 2010)

  1. Nunez, M. J., Jimenez, I. A., Mendoza, C. R., Chavez-Sifontes, M., Martinez, M. L., Ichiishi, E., Tokuda, R., Tokuda, H. and Bazzocchi, I. L. (2016). Dihydro-beta-agarofuran sesquiterpenes from celastraceae species as anti-tumour-promoting agents: Structure-activity relationship. Eur J Med Chem 111: 95-102.
  2. Callies, O., Sanchez-Canete, M. P., Gamarro, F., Jimenez, I. A., Castanys, S. and Bazzocchi, I. L. (2016). Optimization by Molecular Fine Tuning of Dihydro-beta-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance. J Med Chem 59(5): 1880-1890.
  3. Callies, O., Sanchez-Canete, M. P., Gamarro, F., Jimenez, I. A., Castanys, S. and Bazzocchi, I. L. (2015). Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-beta-agarofuran Sesquiterpenes from Celastrus vulcanicola. J Nat Prod 78(4): 736-745.
  4. Callies, O., Bedoya, L. M., Beltran, M., Munoz, A., Calderon, P. O., Osorio, A. A., Jimenez, I. A., Alcami, J. and Bazzocchi, I. L. (2015). Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina. J Nat Prod 78(5): 1045-1055. 
  5. Martin-Rodriguez, A. J., Ticona, J. C., Jimenez, I. A., Flores, N., Fernandez, J. J. and Bazzocchi, I. L. (2015). Flavonoids from Piper delineatum modulate quorum-sensing-regulated phenotypes in Vibrio harveyi. Phytochemistry 117: 98-106.
  6. Sifaoui, I., Lopez-Arencibia, A., Martin-Navarro, C. M., Ticona, J. C., Reyes-Batlle, M., Mejri, M., Jimenez, A. I., Lopez-Bazzocchi, I., Valladares, B., Lorenzo-Morales, J., Abderabba, M. and Pinero, J. E. (2014). In vitro effects of triterpenic acids from olive leaf extracts on the mitochondrial membrane potential of promastigote stage of Leishmania spp. Phytomedicine 21(12): 1689-1694.
  7. Osorio, A. A., Lopez, M. R., Jimenez, I. A., Moujir, L. M., Rodriguez, M. L. and Bazzocchi, I. L. (2014). Elaeodendron orientale as a source of cytotoxic cardenolides. Phytochemistry 105: 60-67.
  8. Miron-Lopez, G., Bazzocchi, I. L., Jimenez-Diaz, I. A., Moujir, L. M., Quijano-Quinones, R., Quijano, L. and Mena-Rejon, G. J. (2014). Cytotoxic diterpenes from roots of Crossopetalum gaumeri, a Celastraceae species from Yucatan Peninsula. Bioorg Med Chem Lett 24(9): 2105-2109.
  9. Sifaoui, I., Lopez-Arencibia, A., Ticona, J. C., Martin-Navarro, C. M., Reyes-Batlle, M., Mejri, M., Lorenzo-Morales, J., Jimenez, A. I., Valladares, B., Lopez-Bazzocchi, I., Abderabba, M. and Pinero, J. E. (2014). Bioassay guided isolation and identification of anti-Acanthamoeba compounds from Tunisian olive leaf extracts. Exp Parasitol 145 Suppl: S111-114.
  10. Giraldo, S. E., Rincón, J., Guerrero, M. F., López, I., Jiménez, I. A., Marder, M., Wasowski, C. and Vergel, N. E. (2013). Valepotriate hydrines isolated from an anticonvulsant fraction of Valeriana pavonii Poepp. & Endl. Latin American Journal of Pharmacy 32, 1224-1230.
  11. Núñez, N. J., Ardiles, A. E., Martínez, M. L., Torres-Romero, D., Jiménez, I. A. and Bazzocchi, I. L. (2013) Triterpenoids from Cassine xylocarpa and Celastrus vulcanicola (Celastraceae). Phytochemistry Letters 6, 148-151.
  12. Magalhaes, C. G., de Fátima Silva, G. D., Duarte, L. P., Bazzocchi, I. L., Díaz, A. J., Moujir, L., Figueiredo, R. C., López, M. R. and Vieira Filho, S. A. (2013). Salicassin, an unprecedented chalcone-diterpene adduct and a quinone methide triterpenoid from Maytenus salicifolia. Helvetica Chimica Acta 96, 1046-1054
  13. Llanos, G. G., Araujo, L. M., Jimenez, I. A., Moujir, L. M. and Bazzocchi, I. L. (2012). Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem 54: 499-511.
  14. Núñez, M. J., Ardiles, A. E., Martínez, M. L., Torres-Romero, D., Jimenez, I. A. and Bazzocchi, I. L. (2012). Unusual D:B-friedobaccharane and oxygenated friedelane-type triterpenoids from Salvadorean Celastraceae species. Phytochemistry Letters, 5, 244-248, 2012.
  15. Ardiles, A. E., Gonzalez-Rodriguez, A., Nunez, M. J., Perestelo, N. R., Pardo, V., Jimenez, I. A., Valverde, A. M. and Bazzocchi, I. L. (2012). Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus. Phytochemistry 84: 116-124.
  16. Osorio, A. A., Munoz, A., Torres-Romero, D., Bedoya, L. M., Perestelo, N. R., Jimenez, I. A., Alcami, J. and Bazzocchi, I. L. (2012). Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription. Eur J Med Chem 52: 295-303.
  17. Nunez, M. J., Reyes, C. P., Jimenez, I. A., Hayashi, H., Tokuda, H. and Bazzocchi, I. L. (2011). ent-Rosane and abietane diterpenoids as cancer chemopreventive agents. Phytochemistry 72(4-5): 385-390.
  18. Kennedy, M. L., Cortes, F., Pinero, J. E., Castanys, S., Lopez-Arencibia, A., Gamarro, F., Bazzocchi, I. L. and Jimenez, I. A. (2011). Leishmanicidal and reversal multidrug resistance constituents from Aeonium lindleyi. Planta Med 77(1): 77-80.
  19. Torres-Romero, D., Jimenez, I. A., Rojas, R., Gilman, R. H., Lopez, M. and Bazzocchi, I. L. (2011). Dihydro-beta-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents. Bioorg Med Chem 19(7): 2182-2189.
  20. Núñez, M. J., Kennedy, M. l., Jiménez, I. A. and Bazzocchi, I. L. (2011). Uragogin and blepharodin, unprecedented hetero-Diels-Alder adducts from Celastraceae species. Tetrahedron 67, 3030-3033
  21. Perestelo, N. R., Jimenez, I. A., Tokuda, H., Hayashi, H. and Bazzocchi, I. L. (2010). Sesquiterpenes from Maytenus jelskii as potential cancer chemopreventive agents. J Nat Prod 73(2): 127-132.
  22. Llanos, G. G., Varela, R. M., Jimenez, I. A., Molinillo, J. M., Macias, F. A. and Bazzocchi, I. L. (2010). Metabolites from Withania aristata with potential phytotoxic activity. Nat Prod Commun 5(7): 1043-1047.
  23. Llanos, G. G., Araujo, L. M., Jimenez, I. A., Moujir, L. M., Vazquez, J. T. and Bazzocchi, I. L. (2010). Withanolides from Withania aristata and their cytotoxic activity. Steroids 75(12): 974-981.
  24. Torres-Romero, D., King-Diaz, B., Strasser, R. J., Jimenez, I. A., Lotina-Hennsen, B. and Bazzocchi, I. L. (2010). Friedelane triterpenes from Celastrus vulcanicola as photosynthetic inhibitors. J Agric Food Chem 58(20): 10847-10854.
Protocols by Isabel L. Bazzocchi
  1. Isolation of Flavonoids from Piper delineatum Leaves by Chromatographic Techniques