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Irving L. Weissman


M.D. in Medicine, Stanford University, Stanford, California,1965

Current position

Director, Stanford Institute of Stem Cell Biology and Regenerative Medicine, Comprehensive Cancer Center, and Stanford Ludwig Center for Stem Cell Research at Stanford; V&D Ludwig Professor of Clinical Cancer Research; Professor, Pathology, Developmental Biology, and by courtesy, Neurosurgery and Biology.


  1. Majeti, R., Park, C. Y. and Weissman, I. L. (2007). Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1(6): 635-645.

  2. Pronk, C. J., Rossi, D. J., Mansson, R., Attema, J. L., Norddahl, G. L., Chan, C. K., Sigvardsson, M., Weissman, I. L. and Bryder, D. (2007). Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 1(4): 428-442.

  3. Czechowicz, A., Kraft, D., Weissman, I. L. and Bhattacharya, D. (2007). Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 318(5854): 1296-1299.

  4. Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J. and Weissman, I. L. (2007). Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447(7145): 725-729.

  5. Weissman, I. (2005). Stem cell research: paths to cancer therapies and regenerative medicine. JAMA 294(11): 1359-1366.

  6. Passegue, E., Wagner, E. F. and Weissman, I. L. (2004). JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells. Cell 119(3): 431-443.

  7. Jamieson, C. H., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., Sawyers, C. L. and Weissman, I. L. (2004). Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med 351(7): 657-667.

  8. Sherwood, R. I., Christensen, J. L., Conboy, I. M., Conboy, M. J., Rando, T. A., Weissman, I. L. and Wagers, A. J. (2004). Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell 119(4): 543-554.

  9. Allsopp, R. C., Morin, G. B., Horner, J. W., DePinho, R., Harley, C. B. and Weissman, I. L. (2003). Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 9(4): 369-371.

  10. Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R. and Weissman, I. L. (2003). A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423(6938): 409-414.

  11. Nakorn, T. N., Miyamoto, T. and Weissman, I. L. (2003). Characterization of mouse clonogenic megakaryocyte progenitors. Proc Natl Acad Sci U S A 100(1): 205-210.

  12. Manz, M. G., Miyamoto, T., Akashi, K. and Weissman, I. L. (2002). Prospective isolation of human clonogenic common myeloid progenitors. Proc Natl Acad Sci U S A 99(18): 11872-11877.

  13. Christensen, J. L. and Weissman, I. L. (2001). Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A 98(25): 14541-14546.

  14. Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L. and Weissman, I. L. (2001). Physiological migration of hematopoietic stem and progenitor cells. Science 294(5548): 1933-1936.

  15. Terskikh, A. V., Easterday, M. C., Li, L., Hood, L., Kornblum, H. I., Geschwind, D. H. and Weissman, I. L. (2001). From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A 98(14): 7934-7939.

  16. Anderson, D. J., Gage, F. H. and Weissman, I. L. (2001). Can stem cells cross lineage boundaries? Nat Med 7(4): 393-395.

  17. Uchida, N., Buck, D. W., He, D., Reitsma, M. J., Masek, M., Phan, T. V., Tsukamoto, A. S., Gage, F. H. and Weissman, I. L. (2000). Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A 97(26): 14720-14725.

  18. Kondo, M., Scherer, D. C., Miyamoto, T., King, A. G., Akashi, K., Sugamura, K. and Weissman, I. L. (2000). Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature 407(6802): 383-386.

  19. Akashi, K., Traver, D., Miyamoto, T. and Weissman, I. L. (2000). A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404(6774): 193-197.

  20. Weissman, I. L. (2000). Stem cells: units of development, units of regeneration, and units in evolution. Cell 100(1): 157-168.

  21. Kondo, M., Weissman, I. L. and Akashi, K. (1997). Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91(5): 661-672.

  22. Baum, C. M., Weissman, I. L., Tsukamoto, A. S., Buckle, A. M. and Peault, B. (1992). Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci U S A 89(7): 2804-2808.

  23. Uchida, N. and Weissman, I. L. (1992). Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J Exp Med 175(1): 175-184.

  24. Spangrude, G. J., Heimfeld, S. and Weissman, I. L. (1988). Purification and characterization of mouse hematopoietic stem cells. Science 241(4861): 58-62.

Protocols by Irving L. Weissman
  1. Denervation of Mouse Lower Hind Limb by Sciatic and Femoral Nerve Transection