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Michael T. Longaker


M.D. in Medicine, Harvard Medical School, MA, 1984
M.B.A., Business, Columbia University, NY, 2003

Current position

Deane P. and Louise Mitchell Professor; Director, Children’s Surgical Research Laboratories;
Co-Director, Institute of Stem Cell Research and Regenerative Medicine; Director, Program in Regenerative Medicine

Publications (since 2010)

  1. Chan, C. K., Lindau, P., Jiang, W., Chen, J. Y., Zhang, L. F., Chen, C. C., Seita, J., Sahoo, D., Kim, J. B., Lee, A., Park, S., Nag, D., Gong, Y., Kulkarni, S., Luppen, C. A., Theologis, A. A., Wan, D. C., DeBoer, A., Seo, E. Y., Vincent-Tompkins, J. D., Loh, K., Walmsley, G. G., Kraft, D. L., Wu, J. C., Longaker, M. T. and Weissman, I. L. (2013). Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. Proc Natl Acad Sci U S A 110(31): 12643-12648.

  2. Levi, B., Hyun, J. S., Montoro, D. T., Lo, D. D., Chan, C. K., Hu, S., Sun, N., Lee, M., Grova, M., Connolly, A. J., Wu, J. C., Gurtner, G. C., Weissman, I. L., Wan, D. C. and Longaker, M. T. (2012). In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc Natl Acad Sci U S A 109(50): 20379-20384.

  3. Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., Pavlovic, A., Lin, S., Chen, R., Hajjar, R. J., Snyder, M. P., Dolmetsch, R. E., Butte, M. J., Ashley, E. A., Longaker, M. T., Robbins, R. C. and Wu, J. C. (2012). Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med 4(130): 130ra147.

  4. Quarto, N., Leonard, B., Li, S., Marchand, M., Anderson, E., Behr, B., Francke, U., Reijo-Pera, R., Chiao, E. and Longaker, M. T. (2012). Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells. Proc Natl Acad Sci U S A 109(1): 215-220.

  5. Rinkevich, Y., Lindau, P., Ueno, H., Longaker, M. T. and Weissman, I. L. (2011). Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip. Nature 476(7361): 409-413.

  6. Levi, B., Nelson, E. R., Li, S., James, A. W., Hyun, J. S., Montoro, D. T., Lee, M., Glotzbach, J. P., Commons, G. W. and Longaker, M. T. (2011). Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells 29(8): 1241-1255.

  7. Levi, B., Wan, D. C., Glotzbach, J. P., Hyun, J., Januszyk, M., Montoro, D., Sorkin, M., James, A. W., Nelson, E. R., Li, S., Quarto, N., Lee, M., Gurtner, G. C. and Longaker, M. T. (2011). CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor beta1 (TGF-beta1) signaling. J Biol Chem 286(45): 39497-39509.

  8. Kwan, M. D., Sellmyer, M. A., Quarto, N., Ho, A. M., Wandless, T. J. and Longaker, M. T. (2011). Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells. J Biol Chem 286(13): 11307-11313.

  9. Jia, F., Wilson, K. D., Sun, N., Gupta, D. M., Huang, M., Li, Z., Panetta, N. J., Chen, Z. Y., Robbins, R. C., Kay, M. A., Longaker, M. T. and Wu, J. C. (2010). A nonviral minicircle vector for deriving human iPS cells. Nat Methods 7(3): 197-199.

Protocols by Michael T. Longaker
  1. Denervation of Mouse Lower Hind Limb by Sciatic and Femoral Nerve Transection