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Laura Cecilia Zelarayan

Education

Ph.D., Centre of Molecular Neurobiology Hamburg (ZMNH), University of Hamburg, 2005

Current position

Research Group leader, Institute of Pharmacology and Toxicology, University Medical of Goettingen, Goettingen

Publications

  1. Zafiriou, M. P., Noack, C., Unsold, B., Didie, M., Pavlova, E., Fischer, H. J., Reichardt, H. M., Bergmann, M. W., El-Armouche, A., Zimmermann, W. H. and Zelarayan, L. C. (2014). Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction. Stem Cells 32(9): 2480-2491.
  2. Kararigas, G., Nguyen, B. T., Zelarayan, L. C., Hassenpflug, M., Toischer, K., Sanchez-Ruderisch, H., Hasenfuss, G., Bergmann, M. W., Jarry, H. and Regitz-Zagrosek, V. (2014). Genetic background defines the regulation of postnatal cardiac growth by 17beta-estradiol through a beta-catenin mechanism. Endocrinology 155(7): 2667-2676.
  3. Renger, A., Zafiriou, M. P., Noack, C., Pavlova, E., Becker, A., Sharkova, K., Bergmann, M. W., El-Armouche, A., Zimmermann, W. H. and Zelarayan, L. C. (2013). The four and a half LIM-domain 2 controls early cardiac cell commitment and expansion via regulating beta-catenin-dependent transcription. Stem Cells 31(5): 928-940.
  4. Zelarayan, L. C., Zafiriou, M. P. and Zimmermann, W. H. (2013). Emerging Concepts in Myocardial Pharmacoregeneration. In: Steinhoff, Gustav (Ed.). Regenerative Medicine- From Protocol to Patient. 25. Netherland: Springer
  5. Noack, C., Zafiriou, M. P., Schaeffer, H. J., Renger, A., Pavlova, E., Dietz, R., Zimmermann, W. H., Bergmann, M. W. and Zelarayan, L. C. (2012). Krueppel-like factor 15 regulates Wnt/beta-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart. EMBO Mol Med 4(9): 992-1007.
  6. Zafiriou, M. P., Zelarayan, L. C., Noack, C., Renger, A., Nigam, S. and Siafaka-Kapadai, A. (2011). Hepoxilin A(3) protects beta-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. Biochim Biophys Acta 1811(6): 361-369.
  7. Honore, S. M., Zelarayan, L. C., Genta, S. B. and Sanchez, S. S. (2011). Neuronal loss and abnormal BMP/Smad signaling in the myenteric plexus of diabetic rats. Auton Neurosci 164(1-2): 51-61.
  8. Zelarayan, L. C., Noack, C., Zafiriou, M. P., Renger, A. and Bergmann, M. W. (2010). Wnt signaling molecules in left ventricular remodeling: focus on dishevelled 1. Hypertension 55(4): 852-854.
  9. Zelarayan, L., Renger, A., Noack, C., Zafiriou, M. P., Gehrke, C., van der Nagel, R., Dietz, R., de Windt, L. and Bergmann, M. W. (2009). NF-kappaB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res 84(3): 416-424.
  10. Bergmann, M. W. and Zelarayan, L. (2009). RALT specifically halts maladaptive cardiac hypertrophy: a new kid on the block. Hypertension 53(3): 454-455.
  11. Dominguez-Frutos, E., Vendrell, V., Alvarez, Y., Zelarayan, L. C., Lopez-Hernandez, I., Ros, M. and Schimmang, T. (2009). Tissue-specific requirements for FGF8 during early inner ear development. Mech Dev 126(10): 873-881.
  12. Zelarayan, L. C., Noack, C., Sekkali, B., Kmecova, J., Gehrke, C., Renger, A., Zafiriou, M. P., van der Nagel, R., Dietz, R., de Windt, L. J., Balligand, J. L. and Bergmann, M. W. (2008). Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation. Proc Natl Acad Sci U S A 105(50): 19762-19767.
  13. Bergmann, M. W., Zelarayan, L. and Gehrke, C. (2008). Treatment-sensitive premature renal and heart senescence in hypertension. Hypertension 52(1): 61-62.
  14. Baurand, A., Zelarayan, L., Betney, R., Gehrke, C., Dunger, S., Noack, C., Busjahn, A., Huelsken, J., Taketo, M. M., Birchmeier, W., Dietz, R. and Bergmann, M. W. (2007). Beta-catenin downregulation is required for adaptive cardiac remodeling. Circ Res 100(9): 1353-1362
  15. Zelarayan, L., Gehrke, C. and Bergmann, M. W. (2007). Role of beta-catenin in adult cardiac remodeling. Cell Cycle 6(17): 2120-2126.
  16. Zelarayan, L. C., Vendrell, V., Alvarez, Y., Dominguez-Frutos, E., Theil, T., Alonso, M. T., Maconochie, M. and Schimmang, T. (2007). Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol 308(2): 379-391.
  17. Wang, X. P., Suomalainen, M., Felszeghy, S., Zelarayan, L. C., Alonso, M. T., Plikus, M. V., Maas, R. L., Chuong, C. M., Schimmang, T. and Thesleff, I. (2007). An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol 5(6): e159.
  18. Carnicero, E., Zelarayan, L. C., Ruttiger, L., Knipper, M., Alvarez, Y., Alonso, M. T. and Schimmang, T. (2004). Differential roles of fibroblast growth factor-2 during development and maintenance of auditory sensory epithelia. J Neurosci Res 77(6): 787-797.
  19. Alvarez, Y., Alonso, M. T., Vendrell, V., Zelarayan, L. C., Chamero, P., Theil, T., Bosl, M. R., Kato, S., Maconochie, M., Riethmacher, D. and Schimmang, T. (2003). Requirements for FGF3 and FGF10 during inner ear formation. Development 130(25): 6329-6338.
  20. Honoré, S. M., Zelarayán, L. C., Genta, S. B., Villecco, E. I. and Sánchez, S. S. (2008). Down regulation of gap junctions and cadherin/beta-catenin complexes in diabetic small intestine. Biocell. 32:P55:76. (IF 0,57) (H: 21)
  21. Honoré, S. M., Zelarayán, L. C., Genta, S. B., Villecco, E. I. and Sánchez, S. S. (2007). Experimental diabetes alters cell-cell contacts in intestinal smooth muscle layer. Biocell 31:P18:80. (IF 0,57) (H: 21)
  22. Fuentes, A., Genta, S. B., Aybar, M., Zelarayán, L. C., Cabrera, W. and Sánchez, S. S. (2001). Victronectin mRNA expression during Amphibian embryo development. Biocell 1:106:25. (IF 0,57) (H: 21)
Protocols by Laura Cecilia Zelarayan
  1. Isolation and Primary Culture of Adult Mouse Cardiac Fibroblasts