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Maria Patapia Zafeiriou


Ph.D. in Biochemisty, Center of Exp. Gynecology & Eicosanoid research, Charité, Berlin & Department of Chemistry, National and Kapodistrian University of Athens, 2008

Current position

Post doctoral fellow, Institute of Pharmacology, Heart Research Center Göttingen (HRCG), University Medical Center Göttingen (UMG), Göttingen


  1. Ott, C., Martens, H., Hassouna, I., Oliveira, B., Erck, C., Zafeiriou, M. P., Peteri, U. K., Hesse, D., Gerhart, S., Altas, B., Kolbow, T., Stadler, H., Kawabe, H., Zimmermann, W. H., Nave, K. A., Schulz-Schaeffer, W., Jahn, O. and Ehrenreich, H. (2015). Widespread expression of erythropoietin receptor in brain and its induction by injury. Mol Med.
  2. Zafiriou, M. P., Noack, C., Unsold, B., Didie, M., Pavlova, E., Fischer, H. J., Reichardt, H. M., Bergmann, M. W., El-Armouche, A., Zimmermann, W. H. and Zelarayan, L. C. (2014). Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction. Stem Cells 32(9): 2480-2491.
  3. Renger, A., Zafiriou, M. P., Noack, C., Pavlova, E., Becker, A., Sharkova, K., Bergmann, M. W., El-Armouche, A., Zimmermann, W. H. and Zelarayan, L. C. (2013). The four and a half LIM-domain 2 controls early cardiac cell commitment and expansion via regulating beta-catenin-dependent transcription. Stem Cells 31(5): 928-940.
  4. Zelarayan, L. C., Zafiriou, M. P. and Zimmermann, W. H. (2013). Emerging Concepts in Myocardial Pharmacoregeneration. In: Steinhoff, Gustav (Ed.). Regenerative Medicine- From Protocol to Patient. 25. Netherland: Springer
  5. Noack, C., Zafiriou, M. P., Schaeffer, H. J., Renger, A., Pavlova, E., Dietz, R., Zimmermann, W. H., Bergmann, M. W. and Zelarayan, L. C. (2012). Krueppel-like factor 15 regulates Wnt/beta-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart. EMBO Mol Med 4(9): 992-1007.
  6. Zafiriou, M. P., Zelarayan, L. C., Noack, C., Renger, A., Nigam, S. and Siafaka-Kapadai, A. (2011). Hepoxilin A(3) protects beta-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid. Biochim Biophys Acta 1811(6): 361-369.
  7. Zelarayan, L. C., Noack, C., Zafiriou, M. P., Renger, A. and Bergmann, M. W. (2010). Wnt signaling molecules in left ventricular remodeling: focus on dishevelled 1. Hypertension 55(4): 852-854.
  8. Deva, R., Sczepanski, M., Saha, S., Zafiriou, M. P., Kerstin, N., Jakobsson, P. J., Inoue, Y. and Nigam, S. (2010). C. albicans activates cyclooxygenase but not its product prostaglandin E(2)in HPV 16-stabilized cells. Eur J Obstet Gynecol Reprod Biol 152(2): 205-209.
  9. Zelarayan, L., Renger, A., Noack, C., Zafiriou, M. P., Gehrke, C., van der Nagel, R., Dietz, R., de Windt, L. and Bergmann, M. W. (2009). NF-kappaB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res 84(3): 416-424.
  10. Zelarayan, L. C., Noack, C., Sekkali, B., Kmecova, J., Gehrke, C., Renger, A., Zafiriou, M. P., van der Nagel, R., Dietz, R., de Windt, L. J., Balligand, J. L. and Bergmann, M. W. (2008). Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation. Proc Natl Acad Sci U S A 105(50): 19762-19767.
  11. Nigam, S., Zafiriou, M. P., Deva, R., Kerstin, N., Geilen, C., Ciccoli, R., Sczepanski, M. and Lohse, M. (2008). Hepoxilin A3 (HXA3) synthase deficiency is causative of a novel ichthyosis form. FEBS Lett 582(2): 279-285.
  12. Zafiriou, M. P., Deva, R., Ciccoli, R., Siafaka-Kapadai, A. and Nigam, S. (2007). Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress? Prostaglandins Leukot Essent Fatty Acids 77(3-4): 209-215.
  13. Nigam, S., Zafiriou, M. P., Deva, R., Ciccoli, R. and Roux-Van der Merwe, R. (2007). Structure, biochemistry and biology of hepoxilins: an update. FEBS J 274(14): 3503-3512.
  14. Ciccoli, R., Sahi, S., Singh, S., Prakash, H., Zafiriou, M. P., Ishdorj, G., Kock, J. L. and Nigam, S. (2005). Oxygenation by COX-2 (cyclo-oxygenase-2) of 3-HETE (3-hydroxyeicosatetraenoic acid), a fungal mimetic of arachidonic acid, produces a cascade of novel bioactive 3-hydroxyeicosanoids. Biochem J 390(Pt 3): 737-747.
  15. Karava, V., Zafiriou, P. M., Fasia, L., Anagnostopoulos, D., Boutou, E., Vorgias, C. E., Maccarrone, M. and Siafaka-Kapadai, A. (2005). Anandamide metabolism by Tetrahymena pyriformis in vitro. Characterization and identification of a 66 kDa fatty acid amidohydrolase. Biochimie 87(11): 967-974.
  16. Nigam, S. and Zafiriou, M. P. (2005). Hepoxilin A3 synthase. Biochem Biophys Res Commun 338(1): 161-168.
Protocols by Maria Patapia Zafeiriou
  1. Isolation and Primary Culture of Adult Mouse Cardiac Fibroblasts