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Hirofumi Yoshikawa


Ph. D. in Agricultural Chemistry, Graduate School of Agricultural and Life Science, The University of Tokyo, 1981

Current position

Professor, Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan

Publications (since 2015)

  1. Ohbayashi, R., Watanabe, S., Ehira, S., Kanesaki, Y., Chibazakura, T. and Yoshikawa, H. (2016). Diversification of DnaA dependency for DNA replication in cyanobacterial evolution. ISME J 10(5): 1113-1121.
  2. Gouda, N., Shiwa, Y., Akashi, M., Yoshikawa, H., Kasahara, K. and Furusawa, M. (2016). Distribution of human single-nucleotide polymorphisms is approximated by the power law and represents a fractal structure. Genes Cells 21(5): 396-407.
  3. Nakahigashi, K., Takai, Y., Kimura, M., Abe, N., Nakayashiki, T., Shiwa, Y., Yoshikawa, H., Wanner, B. L., Ishihama, Y. and Mori, H. (2016). Comprehensive identification of translation start sites by tetracycline-inhibited ribosome profiling. DNA Res 23(3): 193-201.
  4. Miwa, S., Kihira, E., Yoshioka, A., Nakasone, K., Okamoto, S., Hatano, M., Igarashi, M., Eguchi, Y., Kato, A., Ichikawa, N., Sekine, M., Fujita, N., Kanesaki, Y., Yoshikawa, H. and Utsumi, R. (2016). Identification of the Three Genes Involved in Controlling Production of a Phytotoxin Tropolone in Burkholderia plantarii. J Bacteriol 198(11): 1604-1609.
  5. Hirose, Y., Fujisawa, T., Ohtsubo, Y., Katayama, M., Misawa, N., Wakazuki, S., Shimura, Y., Nakamura, Y., Kawachi, M., Yoshikawa, H., Eki, T. and Kanesaki, Y. (2016). Complete Genome Sequence of Cyanobacterium Leptolyngbya sp. NIES-3755. Genome Announc 4(2).
  6. Hirose, Y., Fujisawa, T., Ohtsubo, Y., Katayama, M., Misawa, N., Wakazuki, S., Shimura, Y., Nakamura, Y., Kawachi, M., Yoshikawa, H., Eki, T. and Kanesaki, Y. (2016). Complete genome sequence of cyanobacterium Fischerella sp. NIES-3754, providing thermoresistant optogenetic tools. J Biotechnol 220: 45-46.
  7. Akanuma, G., Yoshizawa, R., Nagakura, M., Shiwa, Y., Watanabe, S., Yoshikawa, H., Ushio, K. and Ishizuka, M. (2016). EliA is required for inducing the stearyl alcohol-mediated expression of secretory proteins and production of polyester in Ralstonia sp. NT80. Microbiology 162(2): 408-419.
  8. Hirose, Y., Fujisawa, T., Ohtsubo, Y., Katayama, M., Misawa, N., Wakazuki, S., Shimura, Y., Nakamura, Y., Kawachi, M., Yoshikawa, H., Eki, T. and Kanesaki, Y. (2016). Complete genome sequence of cyanobacterium Nostoc sp. NIES-3756, a potentially useful strain for phytochrome-based bioengineering. J Biotechnol 218: 51-52.
  9. Yano, K., Masuda, K., Akanuma, G., Wada, T., Matsumoto, T., Shiwa, Y., Ishige, T., Yoshikawa, H., Niki, H., Inaoka, T. and Kawamura, F. (2016). Growth and sporulation defects in Bacillus subtilis mutants with a single rrn operon can be suppressed by amplification of the rrn operon. Microbiology 162(1): 35-45.
  10. Endo, A., Tanizawa, Y., Tanaka, N., Maeno, S., Kumar, H., Shiwa, Y., Okada, S., Yoshikawa, H., Dicks, L., Nakagawa, J. and Arita, M. (2015). Comparative genomics of Fructobacillus spp. and Leuconostoc spp. reveals niche-specific evolution of Fructobacillus spp. BMC Genomics 16(1): 1117.
  11. Nishijima, Y., Kanesaki, Y., Yoshikawa, H., Ogawa, T., Sonoike, K., Nishiyama, Y. and Hihara, Y. (2015). Analysis of spontaneous suppressor mutants from the photomixotrophically grown pmgA-disrupted mutant in the cyanobacterium Synechocystis sp. PCC 6803. Photosynth Res 126(2-3): 465-475.
  12. Sakata, T., Kanesaki, Y., Yoshikawa, H., Tsurumaru, H. and Yamakawa, T. (2015). Draft Genome Sequence of Bradyrhizobium japonicum Is-1, Which Is Incompatible with Rj2 Genotype Soybeans. Genome Announc 3(5).
  13. Tsurumaru, H., Hashimoto, S., Okizaki, K., Kanesaki, Y., Yoshikawa, H. and Yamakawa, T. (2015). A Putative Type III Secretion System Effector Encoded by the MA20_12780 Gene in Bradyrhizobium japonicum Is-34 Causes Incompatibility with Rj4 Genotype Soybeans. Appl Environ Microbiol 81(17): 5812-5819.
  14. Toh-e, A., Ohkusu, M., Li, H. M., Shimizu, K., Takahashi-Nakaguchi, A., Gonoi, T., Kawamoto, S., Kanesaki, Y., Yoshikawa, H. and Nishizawa, M. (2015). Identification of genes involved in the phosphate metabolism in Cryptococcus neoformans. Fungal Genet Biol 80: 19-30.
  15. Shiwa, Y., Yoshikawa, H., Tanaka, T. and Ogura, M. (2015). Bacillus subtilis degSU operon is regulated by the ClpXP-Spx regulated proteolysis system. J Biochem 157(5): 321-330.
  16. Shiwa, Y., Atarashi, H., Tanaka, N., Okada, S., Yoshikawa, H., Endo, A., Miyaji, T. and Nakagawa, J. (2015). Genome Sequences of Three Strains of Lactobacillus paracasei of Different Origins and with Different Cholate Sensitivities. Genome Announc 3(2).
  17. Higashino, A., Shiwa, Y., Yoshikawa, H., Kokubo, T. and Kasahara, K. (2015). Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo. Biosci Biotechnol Biochem 79(3): 384-393.
  18. Chibazakura, T., Toriyabe, Y., Fujii, H., Takahashi, K., Kawakami, M., Kuwamura, H., Haga, H., Ogura, S., Abe, F., Nakajima, M., Yoshikawa, H. and Tanaka, T. (2015). 5-Aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines. Biosci Biotechnol Biochem 79(3): 422-431.
  19. Fujiwara, T., Kanesaki, Y., Hirooka, S., Era, A., Sumiya, N., Yoshikawa, H., Tanaka, K. and Miyagishima, S. Y. (2015). A nitrogen source-dependent inducible and repressible gene expression system in the red alga Cyanidioschyzon merolae. Front Plant Sci 6: 657.
  20. Watanabe, S., Ohbayashi, R., Kanesaki, Y., Saito, N., Chibazakura, T., Soga, T. and Yoshikawa, H. (2015). Intensive DNA Replication and Metabolism during the Lag Phase in Cyanobacteria. PLoS One 10(9): e0136800.
  21. Furuta, Y., Konno, M., Osaki, T., Yonezawa, H., Ishige, T., Imai, M., Shiwa, Y., Shibata-Hatta, M., Kanesaki, Y., Yoshikawa, H., Kamiya, S. and Kobayashi, I. (2015). Microevolution of Virulence-Related Genes in Helicobacter pylori Familial Infection. PLoS One 10(5): e0127197.
Protocols by Hirofumi Yoshikawa
  1. Estimation of the Chromosomal Copy Number in Synechococcus elongatus PCC 7942