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Chun Ju Chang


Ph.D. in Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), Los Angeles, CA, 2007

Current position

Assistant Professor, Department of Basic Medical Sciences, Purdue University

Publications (since 2010)

  1. Chang, C. C., Wu, M. J., Yang, J. Y., Camarillo, I. G. and Chang, C. J. (2015). Chang, C. C., Wu, M. J., Yang, J. Y., Camarillo, I. G. and Chang, C. J. (2015). Leptin-STAT3-G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression. Cancer Res 75(11): 2375-2386.
  2. Chao, C. H., Chang, C. C., Wu, M. J., Ko, H. W., Wang, D., Hung, M. C., Yang, J. Y. and Chang, C. J. (2014). MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest 124(7): 3093-3106.
  3. Tran, L. M., Chang, C. J., Plaisier, S., Wu, S., Dang, J., Mischel, P. S., Liao, J. C., Graeber, T. G. and Wu, H. (2012). Determining PTEN functional status by network component deduced transcription factor activities. PLoS One 7(2): e31053.
  4. Liu, M., Lee, D. F., Chen, C. T., Yen, C. J., Li, L. Y., Lee, H. J., Chang, C. J., Chang, W. C., Hsu, J. M., Kuo, H. P., Xia, W., Wei, Y., Chiu, P. C., Chou, C. K., Du, Y., Dhar, D., Karin, M., Chen, C. H. and Hung, M. C. (2012). IKKalpha activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell 45(2): 171-184.
  5. Chang, C. J. and Hung, M. C. (2012). The role of EZH2 in tumour progression. Br J Cancer 106(2): 243-247.
  6. Lang, J. Y., Hsu, J. L., Meric-Bernstam, F., Chang, C. J., Wang, Q., Bao, Y., Yamaguchi, H., Xie, X., Woodward, W. A., Yu, D., Hortobagyi, G. N. and Hung, M. C. (2011). BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 20(3): 341-356.
  7. Chang, C. J., Yang, J. Y., Xia, W., Chen, C. T., Xie, X., Chao, C. H., Woodward, W. A., Hsu, J. M., Hortobagyi, G. N. and Hung, M. C. (2011). EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-beta-catenin signaling. Cancer Cell 19(1): 86-100.
  8. Chang, C. J., Chao, C. H., Xia, W., Yang, J. Y., Xiong, Y., Li, C. W., Yu, W. H., Rehman, S. K., Hsu, J. L., Lee, H. H., Liu, M., Chen, C. T., Yu, D. and Hung, M. C. (2011). p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol 13(3): 317-323.
  9. Ding, Q., Chang, C. J., Xie, X., Xia, W., Yang, J. Y., Wang, S. C., Wang, Y., Xia, J., Chen, L., Cai, C., Li, H., Yen, C. J., Kuo, H. P., Lee, D. F., Lang, J., Huo, L., Cheng, X., Chen, Y. J., Li, C. W., Jeng, L. B., Hsu, J. L., Li, L. Y., Tan, A., Curley, S. A., Ellis, L. M., Dubois, R. N. and Hung, M. C. (2011). APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest 121(11): 4526-4536.
  10. Yang, J. Y., Chang, C. J., Xia, W., Wang, Y., Wong, K. K., Engelman, J. A., Du, Y., Andreeff, M., Hortobagyi, G. N. and Hung, M. C. (2010). Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Res 70(11): 4709-4718.
Protocols by Chun Ju Chang
  1. High Fat Diet-induced Breast Cancer Model in Rat