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Christopher Shawn Williams

Education

Ph.D. in Cell Biology, Vanderbilt University (Nashville, Tn.), 1999

Current position

Associate Professor (Tenured) of Medicine (Gastroenterology & Hepatology) and Cancer Biology, Vanderbilt University

Publications (Since 2010)

  1. Parang, B., Bradley, A. M., Mittal, M. K., Short, S. P., Thompson, J. J., Barrett, C. W., Naik, R. D., Bilotta, A. J., Washington, M. K., Revetta, F. L., Smith, J. J., Chen, X., Wilson, K. T., Hiebert, S. W. and Williams, C. S. (2016). Myeloid translocation genes differentially regulate colorectal cancer programs. Oncogene, (Epub ahead of print)
  2. Coburn, L. A., Horst, S. N., Allaman, M. M., Brown, C. T., Williams, C. S., Hodges, M. E., Druce, J. P., Beaulieu, D. B., Schwartz, D. A. and Wilson, K. T. (2016). L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Inflamm Bowel Dis, (Epub ahead of print)
  3. Parang, B., Kaz, A.M., Barrett, C.W., Short, S.P., Ning, W., Keating, C.E., Mittal, M.K., Naik, R.D., Washington, M.K., Revetta, F., Smith, J.J., Chen, X., Wilson, K.T., Brand, T., Bader, D.M., Tansey, W.P., Chen, R., Brentnall, T.A., Grady, W.M., Williams, C.S. (2015). BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumorigenesis. Gut, (Epub ahead of print) 
  4. Reddy, V. K., Short, S. P., Barrett, C. W., Mittal, M. K., Keating, C. E., Thompson, J. J., Harris, E. I., Revetta, F., Bader, D. M., Brand, T., Washington, M. K. and Williams, C. S. (2016). BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation. Stem Cells 34(6): 1626-1636.
  5. Barrett, C. W., Reddy, V. K., Short, S. P., Motley, A. K., Lintel, M. K., Bradley, A. M., Freeman, T., Vallance, J., Ning, W., Parang, B., Poindexter, S. V., Fingleton, B., Chen, X., Washington, M. K., Wilson, K. T., Shroyer, N. F., Hill, K. E., Burk, R. F. and Williams, C. S. (2015). Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest 125(7): 2646-2660.
  6. Nguyen, H., Mariotti, J., Bareyan, D., Carnahan, R., Williams, C.S., Engel, M.E.(2015). Anti-mtg16 antibodies reveal mtg16 subcellular distribution and nucleocytoplasmic transport in erythroleukemia cells. Antibody Tech J. 5:27-41
  7. Williams, C. S., Bernard, J. K., Demory Beckler, M., Almohazey, D., Washington, M. K., Smith, J. J. and Frey, M. R. (2015). ERBB4 is over-expressed in human colon cancer and enhances cellular transformation. Carcinogenesis 36(7): 710-718.
  8. Poindexter, S. V., Reddy, V. K., Mittal, M. K., Williams, A. M., Washington, M. K., Harris, E., Mah, A., Hiebert, S. W., Singh, K., Chaturvedi, R., Wilson, K. T., Lund, P. K. and Williams, C. S. (2015). Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Am J Physiol Gastrointest Liver Physiol 308(6): G562-571.
  9. Parang, B., Rosenblatt, D., Williams, A. D., Washington, M. K., Revetta, F., Short, S. P., Reddy, V. K., Hunt, A., Shroyer, N. F., Engel, M. E., Hiebert, S. W. and Williams, C. S. (2015). The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation. FASEB J 29(3): 786-795.
  10. Coburn, L. A., Horst, S. N., Chaturvedi, R., Brown, C. T., Allaman, M. M., Scull, B. P., Singh, K., Piazuelo, M. B., Chitnavis, M. V., Hodges, M. E., Rosen, M. J., Williams, C. S., Slaughter, J. C., Beaulieu, D. B., Schwartz, D. A. and Wilson, K. T. (2013). High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS One 8(12): e82300.
  11. Barrett, C. W., Singh, K., Motley, A. K., Lintel, M. K., Matafonova, E., Bradley, A. M., Ning, W., Poindexter, S. V., Parang, B., Reddy, V. K., Chaturvedi, R., Fingleton, B. M., Washington, M. K., Wilson, K. T., Davies, S. S., Hill, K. E., Burk, R. F. and Williams, C. S. (2013). Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS One 8(7): e67845.
  12. Singh, K., Coburn, L. A., Barry, D. P., Asim, M., Scull, B. P., Allaman, M. M., Lewis, N. D., Washington, M. K., Rosen, M. J., Williams, C. S., Chaturvedi, R. and Wilson, K. T. (2013). Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am J Physiol Gastrointest Liver Physiol 305(3): G225-240.
  13. Rosen, M. J., Chaturvedi, R., Washington, M. K., Kuhnhein, L. A., Moore, P. D., Coggeshall, S. S., McDonough, E. M., Weitkamp, J. H., Singh, A. B., Coburn, L. A., Williams, C. S., Yan, F., Van Kaer, L., Peebles, R. S., Jr. and Wilson, K. T. (2013). STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol 190(4): 1849-1858.
  14. Coburn, L. A., Gong, X., Singh, K., Asim, M., Scull, B. P., Allaman, M. M., Williams, C. S., Rosen, M. J., Washington, M. K., Barry, D. P., Piazuelo, M. B., Casero, R. A., Jr., Chaturvedi, R., Zhao, Z. and Wilson, K. T. (2012). L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS One 7(3): e33546.
  15. Barrett, C. W., Ning, W., Chen, X., Smith, J. J., Washington, M. K., Hill, K. E., Coburn, L. A., Peek, R. M., Chaturvedi, R., Wilson, K. T., Burk, R. F. and Williams, C. S. (2013). Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res 73(3): 1245-1255.
  16. Barrett, C. W., Smith, J. J., Lu, L. C., Markham, N., Stengel, K. R., Short, S. P., Zhang, B., Hunt, A. A., Fingleton, B. M., Carnahan, R. H., Engel, M. E., Chen, X., Beauchamp, R. D., Wilson, K. T., Hiebert, S. W., Reynolds, A. B. and Williams, C. S. (2012). Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. PLoS One 7(12): e51205.
  17. Williams, C. S., Bradley, A. M., Chaturvedi, R., Singh, K., Piazuelo, M. B., Chen, X., McDonough, E. M., Schwartz, D. A., Brown, C. T., Allaman, M. M., Coburn, L. A., Horst, S. N., Beaulieu, D. B., Choksi, Y. A., Washington, M. K., Williams, A. D., Fisher, M. A., Zinkel, S. S., Peek, R. M., Jr., Wilson, K. T. and Hiebert, S. W. (2013). MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut 62(10): 1446-1455.
  18. Williams, C. S., Zhang, B., Smith, J. J., Jayagopal, A., Barrett, C. W., Pino, C., Russ, P., Presley, S. H., Peng, D., Rosenblatt, D. O., Haselton, F. R., Yang, J. L., Washington, M. K., Chen, X., Eschrich, S., Yeatman, T. J., El-Rifai, W., Beauchamp, R. D. and Chang, M. S. (2011). BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest 121(10): 4056-4069.
  19. Barrett, C. W., Fingleton, B., Williams, A., Ning, W., Fischer, M. A., Washington, M. K., Chaturvedi, R., Wilson, K. T., Hiebert, S. W. and Williams, C. S. (2011). MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Cancer Res 71(4): 1302-1312.
  20. Russ, P. K., Pino, C. J., Williams, C. S., Bader, D. M., Haselton, F. R. and Chang, M. S. (2011). Bves modulates tight junction associated signaling. PLoS One 6(1): e14563.
  21. Whittem, C. G., Williams, A. D. and Williams, C. S. (2010). Murine Colitis modeling using Dextran Sulfate Sodium (DSS). J Vis Exp(35).
  22. Hong, S. K., Chaturvedi, R., Piazuelo, M. B., Coburn, L. A., Williams, C. S., Delgado, A. G., Casero, R. A., Jr., Schwartz, D. A. and Wilson, K. T. (2010). Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Inflamm Bowel Dis 16(9): 1557-1566.
Protocols by Christopher Shawn Williams
  1. Whole-mount Enteroid Proliferation Staining