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Hsueh-Fen Juan

Education

Ph.D. in Institute of Biochemical Sciences, National Taiwan University, 1999.

Current position

Professor, Department of Life Science, Institute of Molecular and Cellular Biology and Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University.

Publications (since 2005)

  1. Liaw, H. H., Lin, C. C., Juan, H. F.* and Huang, H. C.* (2013). Differential microRNA regulation correlates with alternative polyadenylation pattern between breast cancer and normal cells. PLoS ONE 8(2): e56958.
  2. Chang, H. Y., Shih, M. H., Huang, H. C., Tsai, S. R., Juan, H. F.* and Lee, S. C.* (2013). Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells. PLoS ONE 8(1): e54117.
  3. Fu, S. C., Huang, H. C., Horton, P.* and Juan, H. F.* (2013). ValidNESs: a database of validated leucine-rich nuclear export signals. Nucleic Acids Res 41(Database issue): D338-343.
  4. Chen, C. Y., Chen, S. T., Juan, H. F.* and Huang, H. C.* (2012). Lengthening of 3'UTR increases with morphological complexity in animal evolution. Bioinformatics 28(24): 3178-3181.
  5. Lu, K. Y., Tao, S. C., Yang, T. C., Ho, Y. H., Lee, C. H., Lin, C. C., Juan, H. F., Huang, H. C., Yang, C. Y., Chen, M. S., Lin, Y. Y., Lu, J. Y., Zhu, H.* and Chen, C. S.* (2012). Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays. Mol Cell Proteomics 11(11): 1177-1190.
  6. Hu, C. W., Lin, M. H., Huang, H. C., Ku, W. C., Yi, T. H., Tsai, C. F., Chen, Y. J., Sugiyama, N., Ishihama, Y.*, Juan, H. F.* and Wu, S. H.* (2012). Phosphoproteomic analysis of Rhodopseudomonas palustris reveals the role of pyruvate phosphate dikinase phosphorylation in lipid production. J Proteome Res 11(11): 5362-5375..
  7. Lin, L. L., Wang, Y. H., Lai, C. Y., Chau, C. L., Su, G. C., Yang, C. Y., Lou, S. Y., Chen, S. K., Hsu, K. H., Lai, Y. L., Wu, W. M., Huang, J. L., Liao, C. H. and Juan, H. F. *(2012). Systems biology of meridians, acupoints, and chinese herbs in disease. Evid Based Complement Alternat Med 2012: 372670.
  8. Lin, L. L., Huang, H. C., Ogihara, S., Wang, J. T., Wu, M. C., McNeil, P. L.*, Chen, C. N.* and Juan, H. F.* (2012). Helicobacter pylori Disrupts Host Cell Membranes, Initiating a Repair Response and Cell Proliferation. Int J Mol Sci 13(8): 10176-10192.
  9. Lin, L. L., Huang, H. C.* and Juan, H. F.* (2012). Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays. PLoS ONE 7(9): e44615.
  10. Chang, H. Y., Huang, H. C., Huang, T. C., Yang, P. C.*, Wang, Y. C.* and Juan, H. F. *(2012). Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response. Cancer Res 72(18): 4696-4706.
  11. Lin, L. L., Huang, H. C.* and Juan, H. F.* (2012). Discovery of biomarkers for gastric cancer: a proteomics approach. J Proteomics 75(11): 3081-3097.
  12. Chang, M. W., Lo, J. M., Juan, H. F., Chang, H. Y. and Chuang, C. Y.* (2012). Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells. PLoS ONE 7(5): e37935.
  13. Tseng, C. W., Huang, H. C., Shih, A. C., Chang, Y. Y., Hsu, C. C., Chang, J. Y., Li, W. H.* and Juan, H. F.* (2012). Revealing the Anti-Tumor Effect of Artificial miRNA p-27-5p on Human Breast Carcinoma Cell Line T-47D. Int J Mol Sci 13(5): 6352-6369.
  14. Lin, C. C., Chen, Y. J., Chen, C. Y., Oyang, Y. J., Juan, H. F.* and Huang, H. C.* (2012). Crosstalk between transcription factors and microRNAs in human protein interaction network. BMC Syst Biol 6: 18. (Highly accessed)
  15. Shih, Y. Y., Nakagawara, A., Lee, H., Juan, H. F., Jeng, Y. M., Lin, D. T., Yang, Y. L., Tsay, Y. G., Huang, M. C., Pan, C. Y., Hsu, W. M. and Liao, Y. F. (2012). Calreticulin mediates nerve growth factor-induced neuronal differentiation. J Mol Neurosci 47(3): 571-581.
  16. Hu, C. W., Chang, Y. L., Chen, S. J., Kuo-Huang, L. L., Liao, J. C., Huang, H. C.* and Juan, H. F.* (2011). Revealing the functions of the transketolase enzyme isoforms in Rhodopseudomonas palustris using a systems biology approach. PLoS ONE 6(12): e28329.
  17. Huang, T. C., Chang, H. Y., Chen, C. Y., Wu, P. Y., Lee, H., Liao, Y. F., Hsu, W. M.*, Huang, H. C.* and Juan, H. F.* (2011). Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR. FEBS Lett 585(22): 3582-3586.
  18. Tsai, S. R.#, Huang, T. C.#, Liang, C. M., Chang, H. Y., Chang, Y. T., Huang, H. C., Juan, H. F.* and Lee, S. C.* (2011). The effect of narrow bandwidth infrared radiation on the growth of Escherichia coli. Applied Physics Letters 99:163704. (# equal contribution)
  19. Shih, Y. Y., Lee, H., Nakagawara, A., Juan, H. F., Jeng, Y. M., Tsay, Y. G., Lin, D. T., Hsieh, F. J., Pan, C. Y., Hsu, W. M.* and Liao, Y. F.* (2011). Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma. PLoS ONE 6(10): e26236.
  20. Chen, S. T., Jeng, Y. M., Chang, C. C., Chang, H. H., Huang, M. C., Juan, H. F., Hsu, C. H., Lee, H., Liao, Y. F., Lee, Y. L., Hsu, W. M.* and Lai, H. S.* (2011). Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma. Cancer Sci 102(12): 2191-2198.
  21. Lee, C. H., Huang, H. C.* and Juan, H. F.* (2011). Reviewing ligand-based rational drug design: the search for an ATP synthase inhibitor. Int J Mol Sci 12(8): 5304-5318.
  22. Chen, C. M., Lin, C. H., Juan, H. F., Hu, F. J., Hsiao, Y. C., Chang, H. Y., Chao, C. Y., Chen, I. C., Lee, L. C., Wang, T. W., Chen, Y. T., Lee-Chen, G. J.* and Wu, Y. R. (2011). ATP13A2 variability in Taiwanese Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet 156B(6): 720-729.
  23. Tseng, C. W., Lin, C. C., Chen, C. N.*, Huang, H. C.* and Juan, H. F.* (2011). Integrative network analysis reveals active microRNAs and their functions in gastric cancer. BMC Syst Biol 5: 99. (Highly accessed)
  24. Tseng, C. W., Yang, J. C., Chen, C. N.*, Huang, H. C., Chuang, K. N., Lin, C. C., Lai, H. S., Lee, P. H., Chang, K. J. and Juan, H. F.* (2011). Identification of 14-3-3beta in human gastric cancer cells and its potency as a diagnostic and prognostic biomarker. Proteomics 11(12): 2423-2439.
  25. Chen, C. Y., Chen, S. T., Fuh, C. S., Juan, H. F.* and Huang, H. C.* (2011). Coregulation of transcription factors and microRNAs in human transcriptional regulatory network. BMC Bioinformatics 12 Suppl 1: S41.
  26. Chen, J. Y., Tang, Y. A., Huang, S. M., Juan, H. F., Wu, L. W., Sun, Y. C., Wang, S. C., Wu, K. W., Balraj, G., Chang, T. T., Li, W. S.*, Cheng, H. C.* and Wang, Y. C.* (2011). A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res 71(2): 473-483.
  27. Hsu, J. W., Huang, H. C., Chen, S. T., Wong, C. H. and Juan, H. F.* (2011). Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation. Evid Based Complement Alternat Med 2011: 358717.
  28. Lin, C. C., Hsiang, J. T., Wu, C. Y., Oyang, Y. J., Juan, H. F.* and Huang, H. C.* (2010). Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy. BMC Syst Biol 4: 138.
  29. Chang, H. H., Lee, H., Hu, M. K., Tsao, P. N., Juan, H. F., Huang, M. C., Shih, Y. Y., Wang, B. J., Jeng, Y. M., Chang, C. L., Huang, S. F., Tsay, Y. G., Hsieh, F. J., Lin, K. H.*, Hsu, W. M.* and Liao, Y. F.* (2010). Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma. Clin Cancer Res 16(17): 4411-4420.
  30. Hwang, Y. C., Lin, C. C., Chang, J. Y., Mori, H., Juan, H. F.* and Huang, H. C.* (2009). Predicting essential genes based on network and sequence analysis. Mol Biosyst 5(12): 1672-1678.
  31. Lin, C. C., Juan, H. F., Hsiang, J. T., Hwang, Y. C., Mori, H.* and Huang, H. C.* (2009). Essential core of protein-protein interaction network in Escherichia coli. J Proteome Res 8(4): 1925-1931.
  32. Chang, Y. M., Juan, H. F., Lee, T. Y., Chang, Y. Y., Yeh, Y. M., Li, W. H.* and Shih, A. C.* (2008). Prediction of human miRNAs using tissue-selective motifs in 3' UTRs. Proc Natl Acad Sci U S A 105(44): 17061-17066. (Highlighted in Nature Biotechnology and in Science-Business eXchange (SciBX))
  33. Fang, Y. C., Huang, H. C., Chen, H. H. and Juan, H. F.* (2008). TCMGeneDIT: a database for associated traditional Chinese medicine, gene and disease information using text mining. BMC Complement Altern Med 8: 58.
  34. Hsu, W. M., Lee, H., Juan, H. F., Shih, Y. Y., Wang, B. J., Pan, C. Y., Jeng, Y. M., Chang, H. H., Lu, M. Y., Lin, K. H., Lai, H. S., Chen, W. J., Tsay, Y. G.*, Liao, Y. F.* and Hsieh, F. J.* (2008). Identification of GRP75 as an independent favorable prognostic marker of neuroblastoma by a proteomics analysis. Clin Cancer Res 14(19): 6237-6245.
  35. Hsu, C. W., Juan, H. F.* and Huang, H. C.* (2008). Characterization of microRNA-regulated protein-protein interaction network. Proteomics 8(10): 1975-1979.
  36. Lin, L. L., Chen, C. N.*, Lin, W. C., Lee, P. H., Chang, K. J., Lai, Y. P., Wang, J. T. and Juan, H. F.* (2008). Annexin A4: A novel molecular marker for gastric cancer with Helicobacter pylori infection using proteomics approach. Proteomics Clin Appl 2(4): 619-634.
  37. Chen, S. T., Pan, T. L., Juan, H. F., Chen, T. Y., Lin, Y. S. and Huang, C. M.* (2008). Breast tumor microenvironment: proteomics highlights the treatments targeting secretome. J Proteome Res 7(4): 1379-1387.
  38. Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. and Juan, H. F. *(2008). Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B. J Proteome Res 7(4): 1433-1444. (ScienceDaily news & ACS weekly news)
  39. Chen, H. W., Huang, H. C., Lin, Y. S., Chang, K. J., Kuo, W. H., Hwa, H. L., Hsieh, F. J.* and Juan, H. F.* (2008). Comparison and identification of estrogen-receptor related gene expression profiles in breast cancer of different ethnic origins. Breast Cancer (Auckl) 1: 35-49.
  40. Tan, Y. H., Lee, K. H., Lin, T., Sun, Y. C., Hsieh-Li, H. M., Juan, H. F.* and Wang, Y. C.* (2008). Cytotoxicity and proteomics analyses of OSU03013 in lung cancer. Clin Cancer Res 14(6): 1823-1830.
  41. Fang, Y. C., Huang, H. C.* and Juan, H. F.* (2008). MeInfoText: associated gene methylation and cancer information from text mining. BMC Bioinformatics 9: 22. (Highly accessed)
  42. Huang, B., Ni, K.-C., Chen, S.-L., Juan, H.-F.*, Chen Y.-M.* (2008). Elucidating the growth regulation of brassinosteroids in mung bean epicotyls using a proteomics approach. Proteomics Research Journal 1:1-18.
  43. Lien, H. C., Hsiao, Y. H., Lin, Y. S., Yao, Y. T., Juan, H. F., Kuo, W. H., Hung, M. C., Chang, K. J. and Hsieh, F. J.* (2007). Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 26(57): 7859-7871.
  44. Cheng, K. C., Huang, H. C., Chen, J. H., Hsu, J. W., Cheng, H. C., Ou, C. H., Yang, W. B., Chen, S. T., Wong, C. H. and Juan, H. F.* (2007). Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction. BMC Genomics 8: 411. (Highly accessed)
  45. Huang, T. C., Huang, H. C., Chang, C. C., Chang, H. Y., Ou, C. H., Hsu, C. H., Chen, S. T. and Juan, H. F.* (2007). An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells. FEBS Lett 581(18): 3517-3522.
  46. Leu, J. H., Chang, C. C., Wu, J. L., Hsu, C. W., Hirono, I., Aoki, T., Juan, H. F., Lo, C. F., Kou, G. H.* and Huang, H. C.* (2007). Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon. BMC Genomics 8: 120. (Highly accessed)
  47. Fang, Y. C., Sun, W. H.*, Wu, L. C., Huang, H. D., Juan, H. F. and Horng, J. T.* (2006). RINGdb: an integrated database for G protein-coupled receptors and regulators of G protein signaling. BMC Genomics 7: 317. (Highly accessed)
  48. Tseng, H. W., Juan, H. F., Huang, H. C., Lin, J. Y. C., Sinchaikul, S., Chen, C. F., Chen, S. T.* and Wang, G. J.* (2006). A systems biology study of lipopolysaccharide-stimulated responses in rat aortic endothelial cell. Proteomics 6:5915-5928.
  49. Chen, Y. R., Juan, H. F., Huang, H. C., Huang, H. H., Lee, Y. J., Liao, M. Y., Tseng, C. W., Lin, L. L., Chen, J. Y., Wang, M. J., Chen, J. H.* and Chen, Y. J.* (2006). Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells. J Proteome Res 5(10): 2727-2742.
  50. Huang, B., Chu, C. H., Chen, S. L., Juan, H. F.* and Chen, Y. M.* (2006). A proteomics study of the mung bean epicotyl regulated by brassinosteroids under conditions of chilling stress. Cell Mol Biol Lett 11(2): 264-278.
  51. Juan, H. F.*, Wang, I. H., Huang, T. C., Li, J. J., Chen, S. T. and Huang, H. C. (2006). Proteomics analysis of a novel compound: cyclic RGD in breast carcinoma cell line MCF-7. Proteomics 6(10): 2991-3000. (Cover Picture)
  52. Lee, T. Y., Horng, J. T., Juan, H. F., Huang, H. D., Wu, L. C., Tsai, M. F. and Huang, H. C. (2006). An agent-based system to discover protein-protein interactions, identify protein complexes and proteins with multiple peptide mass fingerprints. J Comput Chem 27(9): 1020-1032.
  53. Huang, H. D., Lee, T. Y., Wu, L. C., Lin, F. M., Juan, H. F., Horng, J. T. and Tsou, A. P. (2005). MultiProtIdent: identifying proteins using database search and protein-protein interactions. J Proteome Res 4(3): 690-697.
  54. Juan, H. F.*, Chang, S. C., Huang, H. C. and Chen, S. T. (2005). A new application of microwave technology to proteomics. Proteomics 5(4): 840-842.

    *corresponding author
Protocols by Hsueh-Fen Juan
  1. Flow Cytometric Detection of Mitochondrial Membrane Potential
  2. Flow Cytometric Detection of Reactive Oxygen Species