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Kate L Graham


PhD, Department of Microbiology and Immunology, The University of Melbourne, 2004

Current position

Kate Graham is a Research Fellow at St Vincent’s Institute in Melbourne. Her research is focused on understanding the interaction between islets and immune cells in type 1 diabetes. She is also interested in the potential for viruses to trigger autoimmune type 1 diabetes.


  1. Trivedi, P., Graham, K. L., Krishnamurthy, B., Fynch, S., Slattery, R. M., Kay, T. W. and Thomas, H. E. (2016). Perforin facilitates beta cell killing and regulates autoreactive CD8(+) T-cell responses to antigen in mouse models of type 1 diabetes. Immunol Cell Biol 94(4): 334-341.
  2. Scott, J. W., Galic, S., Graham, K. L., Foitzik, R., Ling, N. X., Dite, T. A., Issa, S. M., Langendorf, C. G., Weng, Q. P., Thomas, H. E., Kay, T. W., Birnberg, N. C., Steinberg, G. R., Kemp, B. E. and Oakhill, J. S. (2015). Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. Chem Biol 22(6): 705-711.
  3. Krishnamurthy, B., Chee, J., Jhala, G., Trivedi, P., Catterall, T., Selck, C., Gurzov, E. N., Brodnicki, T. C., Graham, K. L., Wali, J. A., Zhan, Y., Gray, D., Strasser, A., Allison, J., Thomas, H. E. and Kay, T. W. (2015). BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells. Diabetes 64(9): 3229-3238.
  4. Quah, H. S., Miranda-Hernandez, S., Khoo, A., Harding, A., Fynch, S., Elkerbout, L., Brodnicki, T. C., Baxter, A. G., Kay, T. W., Thomas, H. E. and Graham, K. L. (2014). Deficiency in type I interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice. Diabetes 63(3): 1032-1040.
  5. Chee, J., Ko, H. J., Skowera, A., Jhala, G., Catterall, T., Graham, K. L., Sutherland, R. M., Thomas, H. E., Lew, A. M., Peakman, M., Kay, T. W. and Krishnamurthy, B. (2014). Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes. J Immunol 192(2): 572-580.
  6. Pane, J. A., Webster, N. L., Graham, K. L., Holloway, G., Zufferey, C. and Coulson, B. S. (2013). Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes. Diabetologia 56(3): 573-582.
  7. Graham, K. L., Sutherland, R. M., Mannering, S. I., Zhao, Y., Chee, J., Krishnamurthy, B., Thomas, H. E., Lew, A. M. and Kay, T. W. (2012). Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease. Rev Diabet Stud 9(4): 148-168.
  8. Angstetra, E., Graham, K. L., Zhao, Y., Irvin, A. E., Elkerbout, L., Santamaria, P., Slattery, R. M., Kay, T. W. and Thomas, H. E. (2012). An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes. Immunol Cell Biol 90(2): 243-247.
  9. Graham, K. L., Krishnamurthy, B., Fynch, S., Ayala-Perez, R., Slattery, R. M., Santamaria, P., Thomas, H. E. and Kay, T. W. (2012). Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression. Eur J Immunol 42(7): 1717-1722.
  10. Graham, K. L., Krishnamurthy, B., Fynch, S., Mollah, Z. U., Slattery, R., Santamaria, P., Kay, T. W. and Thomas, H. E. (2011). Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes. Am J Pathol 178(6): 2716-2725.
Protocols by Kate L Graham
  1. Isolation and Culture of the Islets of Langerhans from Mouse Pancreas