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Kate L Graham

Education

PhD, Department of Microbiology and Immunology, The University of Melbourne, 2004

Current position

Kate Graham is a Research Fellow at St Vincent’s Institute in Melbourne. Her research is focused on understanding the interaction between islets and immune cells in type 1 diabetes. She is also interested in the potential for viruses to trigger autoimmune type 1 diabetes.

Publications

  1. Trivedi, P., Graham, K. L., Krishnamurthy, B., Fynch, S., Slattery, R. M., Kay, T. W. and Thomas, H. E. (2016). Perforin facilitates beta cell killing and regulates autoreactive CD8(+) T-cell responses to antigen in mouse models of type 1 diabetes. Immunol Cell Biol 94(4): 334-341.
  2. Scott, J. W., Galic, S., Graham, K. L., Foitzik, R., Ling, N. X., Dite, T. A., Issa, S. M., Langendorf, C. G., Weng, Q. P., Thomas, H. E., Kay, T. W., Birnberg, N. C., Steinberg, G. R., Kemp, B. E. and Oakhill, J. S. (2015). Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. Chem Biol 22(6): 705-711.
  3. Krishnamurthy, B., Chee, J., Jhala, G., Trivedi, P., Catterall, T., Selck, C., Gurzov, E. N., Brodnicki, T. C., Graham, K. L., Wali, J. A., Zhan, Y., Gray, D., Strasser, A., Allison, J., Thomas, H. E. and Kay, T. W. (2015). BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells. Diabetes 64(9): 3229-3238.
  4. Quah, H. S., Miranda-Hernandez, S., Khoo, A., Harding, A., Fynch, S., Elkerbout, L., Brodnicki, T. C., Baxter, A. G., Kay, T. W., Thomas, H. E. and Graham, K. L. (2014). Deficiency in type I interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice. Diabetes 63(3): 1032-1040.
  5. Chee, J., Ko, H. J., Skowera, A., Jhala, G., Catterall, T., Graham, K. L., Sutherland, R. M., Thomas, H. E., Lew, A. M., Peakman, M., Kay, T. W. and Krishnamurthy, B. (2014). Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes. J Immunol 192(2): 572-580.
  6. Pane, J. A., Webster, N. L., Graham, K. L., Holloway, G., Zufferey, C. and Coulson, B. S. (2013). Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes. Diabetologia 56(3): 573-582.
  7. Graham, K. L., Sutherland, R. M., Mannering, S. I., Zhao, Y., Chee, J., Krishnamurthy, B., Thomas, H. E., Lew, A. M. and Kay, T. W. (2012). Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease. Rev Diabet Stud 9(4): 148-168.
  8. Angstetra, E., Graham, K. L., Zhao, Y., Irvin, A. E., Elkerbout, L., Santamaria, P., Slattery, R. M., Kay, T. W. and Thomas, H. E. (2012). An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes. Immunol Cell Biol 90(2): 243-247.
  9. Graham, K. L., Krishnamurthy, B., Fynch, S., Ayala-Perez, R., Slattery, R. M., Santamaria, P., Thomas, H. E. and Kay, T. W. (2012). Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression. Eur J Immunol 42(7): 1717-1722.
  10. Graham, K. L., Krishnamurthy, B., Fynch, S., Mollah, Z. U., Slattery, R., Santamaria, P., Kay, T. W. and Thomas, H. E. (2011). Autoreactive cytotoxic T lymphocytes acquire higher expression of cytotoxic effector markers in the islets of NOD mice after priming in pancreatic lymph nodes. Am J Pathol 178(6): 2716-2725.
Protocols by Kate L Graham
  1. Isolation and Culture of the Islets of Langerhans from Mouse Pancreas