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Claude Leclerc

Education

Ph.D es Sciences, University of Paris VII, 1981

Current position

Professor and Head of Unit of Immune Regulation and Vaccinologie, Director of Unit INSERM 1041, Department of Immunology, Pasteur Institute, Paris, France

Publications (Since 2010)

  1. Laubreton, D., Bay, S., Sedlik, C., Artaud, C., Ganneau, C., Deriaud, E., Viel, S., Puaux, A. L., Amigorena, S., Gerard, C., Lo-Man, R. and Leclerc, C. (2016). The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity. Cancer Immunol Immunother 65(3): 315-325.
  2. Coelho, H., Matsushita, T., Artigas, G., Hinou, H., Canada, F. J., Lo-Man, R., Leclerc, C., Cabrita, E. J., Jimenez-Barbero, J., Nishimura, S., Garcia-Martin, F. and Marcelo, F. (2015). The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR. J Am Chem Soc 137(39): 12438-12441.
  3. Thomas, S., Rouilly, V., Patin, E., Alanio, C., Dubois, A., Delval, C., Marquier, L. G., Fauchoux, N., Sayegrih, S., Vray, M., Duffy, D., Quintana-Murci, L., Albert, M. L. and Milieu Interieur, C. (2015). The Milieu Interieur study - an integrative approach for study of human immunological variance. Clin Immunol 157(2): 277-293.
  4. Lemoine, S., Jaron, B., Tabka, S., Ettreiki, C., Deriaud, E., Zhivaki, D., Le Ray, C., Launay, O., Majlessi, L., Tissieres, P., Leclerc, C. and Lo-Man, R. (2015). Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. J Allergy Clin Immunol 136(5): 1355-1368 e1351-1315.
  5. Chaoul, N., Fayolle, C., Desrues, B., Oberkampf, M., Tang, A., Ladant, D. and Leclerc, C. (2015). Rapamycin Impairs Antitumor CD8+ T-cell Responses and Vaccine-Induced Tumor Eradication. Cancer Res 75(16): 3279-3291.
  6. Daleke-Schermerhorn, M. H., Felix, T., Soprova, Z., Ten Hagen-Jongman, C. M., Vikstrom, D., Majlessi, L., Beskers, J., Follmann, F., de Punder, K., van der Wel, N. N., Baumgarten, T., Pham, T. V., Piersma, S. R., Jimenez, C. R., van Ulsen, P., de Gier, J. W., Leclerc, C., Jong, W. S. and Luirink, J. (2014). Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach. Appl Environ Microbiol 80(18): 5854-5865.
  7. Dadaglio, G., Fayolle, C., Zhang, X., Ryffel, B., Oberkampf, M., Felix, T., Hervas-Stubbs, S., Osicka, R., Sebo, P., Ladant, D. and Leclerc, C. (2014). Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses. J Immunol 193(4): 1787-1798.
  8. Hervas-Stubbs, S., Riezu-Boj, J. I., Mancheno, U., Rueda, P., Lopez, L., Alignani, D., Rodriguez-Garcia, E., Thieblemont, N. and Leclerc, C. (2014). Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming. J Immunol 193(3): 1151-1161.
  9. Zhang, X., Casartelli, N., Lemoine, S., Mozeleski, B., Azria, E., Le Ray, C., Schwartz, O., Launay, O., Leclerc, C. and Lo-Man, R. (2014). Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings. J Infect Dis 210(3): 424-434.
  10. Duffy, D., Rouilly, V., Libri, V., Hasan, M., Beitz, B., David, M., Urrutia, A., Bisiaux, A., Labrie, S. T., Dubois, A., Boneca, I. G., Delval, C., Thomas, S., Rogge, L., Schmolz, M., Quintana-Murci, L., Albert, M. L. and Milieu Interieur, C. (2014). Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli. Immunity 40(3): 436-450.
  11. Zhang, X., Mozeleski, B., Lemoine, S., Deriaud, E., Lim, A., Zhivaki, D., Azria, E., Le Ray, C., Roguet, G., Launay, O., Vanet, A., Leclerc, C. and Lo-Man, R. (2014). CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med 6(238): 238ra272.
  12. van Vliet, S. J., Bay, S., Vuist, I. M., Kalay, H., Garcia-Vallejo, J. J., Leclerc, C. and van Kooyk, Y. (2013). MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-alpha secretion. J Leukoc Biol 94(2): 315-323.
  13. Zhang, X., Lepelley, A., Azria, E., Lebon, P., Roguet, G., Schwartz, O., Launay, O., Leclerc, C. and Lo-Man, R. (2013). Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses. PLoS One 8(1): e52003.
  14. Mazal, D., Lo-Man, R., Bay, S., Pritsch, O., Deriaud, E., Ganneau, C., Medeiros, A., Ubillos, L., Obal, G., Berois, N., Bollati-Fogolin, M., Leclerc, C. and Osinaga, E. (2013). Monoclonal antibodies toward different Tn-amino acid backbones display distinct recognition patterns on human cancer cells. Implications for effective immuno-targeting of cancer. Cancer Immunol Immunother 62(6): 1107-1122.
  15. Dong, H., Stanek, O., Salvador, F. R., Langer, U., Morillon, E., Ung, C., Sebo, P., Leclerc, C. and Majlessi, L. (2013). Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells. Mucosal Immunol 6(3): 522-534.
  16. Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pawlik, A., Fiette, L., Orgeur, M., Fabre, M., Parmentier, C., Frigui, W., Simeone, R., Boritsch, E. C., Debrie, A. S., Willery, E., Walker, D., Quail, M. A., Ma, L., Bouchier, C., Salvignol, G., Sayes, F., Cascioferro, A., Seemann, T., Barbe, V., Locht, C., Gutierrez, M. C., Leclerc, C., Bentley, S. D., Stinear, T. P., Brisse, S., Medigue, C., Parkhill, J., Cruveiller, S. and Brosch, R. (2013). Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Nat Genet 45(2): 172-179.
  17. Stanek, O., Linhartova, I., Majlessi, L., Leclerc, C. and Sebo, P. (2012). Complexes of streptavidin-fused antigens with biotinylated antibodies targeting receptors on dendritic cell surface: a novel tool for induction of specific T-cell immune responses. Mol Biotechnol 51(3): 221-232.
  18. Rudilla, F., Fayolle, C., Casares, N., Durantez, M., Arribillaga, L., Lozano, T., Villanueva, L., Pio, R., Sarobe, P., Leclerc, C., Prieto, J. and Lasarte, J. J. (2012). Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses. Vaccine 30(18): 2848-2858.
  19. Bottai, D., Di Luca, M., Majlessi, L., Frigui, W., Simeone, R., Sayes, F., Bitter, W., Brennan, M. J., Leclerc, C., Batoni, G., Campa, M., Brosch, R. and Esin, S. (2012). Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Mol Microbiol 83(6): 1195-1209.
  20. Mansilla, C., Berraondo, P., Durantez, M., Martinez, M., Casares, N., Arribillaga, L., Rudilla, F., Fioravanti, J., Lozano, T., Villanueva, L., Sarobe, P., Borras, F., Leclerc, C., Prieto, J. and Lasarte, J. J. (2012). Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin. Int J Cancer 131(3): 641-651.
  21. Sainz-Perez, A., Lim, A., Lemercier, B. and Leclerc, C. (2012). The T-cell receptor repertoire of tumor-infiltrating regulatory T lymphocytes is skewed toward public sequences. Cancer Res 72(14): 3557-3569.
  22. Fiser, R., Masin, J., Bumba, L., Pospisilova, E., Fayolle, C., Basler, M., Sadilkova, L., Adkins, I., Kamanova, J., Cerny, J., Konopasek, I., Osicka, R., Leclerc, C. and Sebo, P. (2012). Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores. PLoS Pathog 8(4): e1002580.
  23. Guillerey, C., Mouries, J., Polo, G., Doyen, N., Law, H. K., Chan, S., Kastner, P., Leclerc, C. and Dadaglio, G. (2012). Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice. Blood 120(1): 90-99.
  24. Sayes, F., Sun, L., Di Luca, M., Simeone, R., Degaiffier, N., Fiette, L., Esin, S., Brosch, R., Bottai, D., Leclerc, C. and Majlessi, L. (2012). Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential. Cell Host Microbe 11(4): 352-363.
  25. Olivier, A., Sainz-Perez, A., Dong, H., Sparwasser, T., Majlessi, L. and Leclerc, C. (2011). The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells. Eur J Immunol 41(8): 2303-2313.
  26. Freire, T., Lo-Man, R., Bay, S. and Leclerc, C. (2011). Tn glycosylation of the MUC6 protein modulates its immunogenicity and promotes the induction of Th17-biased T cell responses. J Biol Chem 286(10): 7797-7811.
  27. Bottai, D., Majlessi, L., Simeone, R., Frigui, W., Laurent, C., Lenormand, P., Chen, J., Rosenkrands, I., Huerre, M., Leclerc, C., Cole, S. T. and Brosch, R. (2011). ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis. J Infect Dis 203(8): 1155-1164.
  28. Mascarell, L., Saint-Lu, N., Moussu, H., Zimmer, A., Louise, A., Lone, Y., Ladant, D., Leclerc, C., Tourdot, S., Van Overtvelt, L. and Moingeon, P. (2011). Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice. Mucosal Immunol 4(6): 638-647.
  29. Leclerc, C. (2010). Towards a rational approach to vaccine development. Hum Vaccin 6(4): 292-296.
  30. Durantez, M., Fayolle, C., Casares, N., Belsue, V., Riezu-Boj, J. I., Sarobe, P., Prieto, J., Borras-Cuesta, F., Leclerc, C. and Lasarte, J. J. (2010). Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis. Vaccine 28(44): 7146-7154.
  31. Fayolle, C., Davi, M., Dong, H., Ritzel, D., Le Page, A., Knipping, F., Majlessi, L., Ladant, D. and Leclerc, C. (2010). Induction of anti-Tat neutralizing antibodies by the CyaA vector targeting dendritic cells: influence of the insertion site and of the delivery of multicopies of the dominant Tat B-cell epitope. Vaccine 28(42): 6930-6941.
  32. Osickova, A., Masin, J., Fayolle, C., Krusek, J., Basler, M., Pospisilova, E., Leclerc, C., Osicka, R. and Sebo, P. (2010). Adenylate cyclase toxin translocates across target cell membrane without forming a pore. Mol Microbiol 75(6): 1550-1562.
  33. Freire, T., Zhang, X., Deriaud, E., Ganneau, C., Vichier-Guerre, S., Azria, E., Launay, O., Lo-Man, R., Bay, S. and Leclerc, C. (2010). Glycosidic Tn-based vaccines targeting dermal dendritic cells favor germinal center B-cell development and potent antibody response in the absence of adjuvant. Blood 116(18): 3526-3536.
Protocols by Claude Leclerc
  1. In vivo OVA-specific Cytotoxic CD8+ T Cell Killing Assay