Education
Ph.D. in Molecular Biology, School of Medicine, Sichuan University, P.R. China.
Current position
Associate professor of Orthopaedics and Medicine, Department of Orthopaedics, Alpert Medical School, Brown University
Publications
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Liu, X., Zheng, H., Li, X., Wang, S., Meyerson, H. J., Yang, W., Neel, B. G. and Qu, C. K. (2016). Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proc Natl Acad Sci U S A 113(4): 984-989.
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Zhou, Y., Mohan, A., Moore, D. C., Lin, L., Zhou, F. L., Cao, J., Wu, Q., Qin, Y. X., Reginato, A. M., Ehrlich, M. G. and Yang, W. (2015). SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion. FASEB J 29(5): 1635-1645.
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Bowen, M. E., Ayturk, U. M., Kurek, K. C., Yang, W. and Warman, M. L. (2014). SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates. PLoS Genet 10(5): e1004364.
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Yang, W. and Neel, B. G. (2013). From an orphan disease to a generalized molecular mechanism: PTPN11 loss-of-function mutations in the pathogenesis of metachondromatosis. Rare Dis 1: e26657.
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Yang, W., Wang, J., Moore, D. C., Liang, H., Dooner, M., Wu, Q., Terek, R., Chen, Q., Ehrlich, M. G., Quesenberry, P. J. and Neel, B. G. (2013). Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling. Nature 499(7459): 491-495.
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Yang, W., Klaman, L. D., Chen, B., Araki, T., Harada, H., Thomas, S. M., George, E. L. and Neel, B. G. (2006). An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. Dev Cell 10(3): 317-327.