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Desheng Hu


Ph. D. in Immunology, Department of Immunology, Leibniz Institute for Ageing research-Fritz Lipmann Institute (FLI), Jena, Germany

Current position

Postdoc in Immunology, Institute of Immunology, Biomedical Center, Ludwig-Maximilians-Universität München, Germany


  1. Meininger, I., Griesbach, R. A., Hu, D., Gehring, T., Seeholzer, T., Bertossi, A., Kranich, J., Oeckinghaus, A., Eitelhuber, A. C., Greczmiel, U., Gewies, A., Schmidt-Supprian, M., Ruland, J., Brocker, T., Heissmeyer, V., Heyd, F. and Krappmann, D. (2016). Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. Nat Commun 7: 11292.
  2. Hu, D., Mohanta, S. K., Yin, C., Peng, L., Ma, Z., Srikakulapu, P., Grassia, G., MacRitchie, N., Dever, G., Gordon, P., Burton, F. L., Ialenti, A., Sabir, S. R., McInnes, I. B., Brewer, J. M., Garside, P., Weber, C., Lehmann, T., Teupser, D., Habenicht, L., Beer, M., Grabner, R., Maffia, P., Weih, F. and Habenicht, A. J. (2015). Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin beta Receptors. Immunity 42(6): 1100-1115.
  3. Jeltsch, K. M.*, Hu, D.*, Brenner, S., Zoller, J., Heinz, G. A., Nagel, D., Vogel, K. U., Rehage, N., Warth, S. C., Edelmann, S. L., Gloury, R., Martin, N., Lohs, C., Lech, M., Stehklein, J. E., Geerlof, A., Kremmer, E., Weber, A., Anders, H. J., Schmitz, I., Schmidt-Supprian, M., Fu, M., Holtmann, H., Krappmann, D., Ruland, J., Kallies, A., Heikenwalder, M. and Heissmeyer, V. (2014). Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immunol 15(11): 1079-1089. (*Equal contribution)
  4. Srivastava, M., Duan, G., Kershaw, N. J., Athanasopoulos, V., Yeo, J. H., Ose, T., Hu, D., Brown, S. H., Jergic, S., Patel, H. R., Pratama, A., Richards, S., Verma, A., Jones, E. Y., Heissmeyer, V., Preiss, T., Dixon, N. E., Chong, M. M., Babon, J. J. and Vinuesa, C. G. (2015). Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis. Nat Commun 6: 6253.
  5. Yin, C., Mohanta, S., Ma, Z., Weber, C., Hu, D., Weih, F. and Habenicht, A. (2015). Generation of Aorta Transcript Atlases of Wild-Type and Apolipoprotein E-null Mice by Laser Capture Microdissection-Based mRNA Expression Microarrays. Methods Mol Biol 1339: 297-308.
  6. Mohanta, S. K., Yin, C., Peng, L., Srikakulapu, P., Bontha, V., Hu, D., Weih, F., Weber, C., Gerdes, N. and Habenicht, A. J. (2014). Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis. Circ Res 114(11): 1772-1787.
  7. Krljanac, B., Weih, D., Jacobsen, I. D., Hu, D., Koliesnik, I., Reppe, K., Witzenrath, M. and Weih, F. (2014). NF-kappaB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens. Eur J Immunol 44(3): 662-672.
  8. Weih, F., Grabner, R., Hu, D., Beer, M. and Habenicht, A. J. (2012). Control of dichotomic innate and adaptive immune responses by artery tertiary lymphoid organs in atherosclerosis. Front Physiol 3: 226.
  9. Beer, M., Doepping, S., Hildner, M., Weber, G., Grabner, R., Hu, D., Mohanta, S. K., Srikakulapu, P., Weih, F. and Habenicht, A. J. (2011). Laser-capture microdissection of hyperlipidemic/ApoE(-)/(-) mouse aorta atherosclerosis. Methods Mol Biol 755: 417-428.
  10. Grabner, R., Lotzer, K., Dopping, S., Hildner, M., Radke, D., Beer, M., Spanbroek, R., Lippert, B., Reardon, C. A., Getz, G. S., Fu, Y. X., Hehlgans, T., Mebius, R. E., van der Wall, M., Kruspe, D., Englert, C., Lovas, A., Hu, D., Randolph, G. J., Weih, F. and Habenicht, A. J. (2009). Lymphotoxinβ receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J Exp Med 206(1): 233-248.
Protocols by Desheng Hu
  1. Preparation of Single Cell Suspensions from Mouse Aorta
  2. Aorta Atherosclerosis Lesion Analysis in Hyperlipidemic Mice