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Xiaochen Wang

Education

Ph.D. National key Laboratory of Protein Engineering and Plant Genetic Engineering (NLPGE), College of Life Sciences, Peking University, China, 1999.

Current position

Associate Investigator, National Institute of Biological Sciences, Beijing, China.

Publications

  1. Li, X., Chen, B., Yoshina, S., Cai, T., Yang, F., Mitani, S. and Wang, X. (2013). Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants. Mol Biol Cell 24(8): 1163-1175.
  2. Huang, J., Wang, H., Chen, Y., Wang, X.* and Zhang, H.* (2012). Residual body removal during spermatogenesis in C. elegans requires genes that mediate cell corpse clearance. Development 139(24): 4613-4622. (*Co-corresponding author)
  3. Liu, B., Du, H., Rutkowski, R., Gartner, A. and Wang, X. (2012). LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science 337(6092): 351-354.
  4. Zhang, Y., Wang, H., Kage-Nakadai, E., Mitani, S. and Wang, X. (2012). C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment. Curr Biol 22(14): 1276-1284.
  5. Kang, Y., Zhao, D., Liang, H., Liu, B., Zhang, Y., Liu, Q., Wang, X.* and Liu, Y.* (2012). Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment. Genes Dev 26(12): 1339-1350. (*Co-corresponding author)
  6. Li, W., Zou, W., Yang, Y., Chai, Y., Chen, B., Cheng, S., Tian, D., Wang, X.*, Vale, R. D. *and Ou, G.* (2012). Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. J Cell Biol 197(1): 27-35. (*Co-corresponding author)
  7. Chen, B., Jiang, Y., Zeng, S., Yan, J., Li, X., Zhang, Y., Zou, W. and Wang, X. (2010). Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1. PLoS Genet 6(12): e1001235.
  8. Guo, P. and Wang, X. (2010). Rab GTPases act in sequential steps to regulate phagolysosome formation. Small GTPases 1(3): 170-173.
  9. Guo, P., Hu, T., Zhang, J., Jiang, S. and Wang, X. (2010). Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. Proc Natl Acad Sci U S A 107(42): 18016-18021.
  10. Wang, X.*, Li, W., Zhao, D., Liu, B., Shi, Y., Chen, B., Yang, H., Guo, P., Geng, X., Shang, Z., Peden, E., Kage-Nakadai, E., Mitani, S. and Xue, D.* (2010). Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol 12(7): 655-664. (*Co-corresponding author)
  11. Zou, W., Lu, Q., Zhao, D., Li, W., Mapes, J., Xie, Y. and Wang, X. (2009). Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet 5(10): e1000679.
  12. Li, W., Zou, W., Zhao, D., Yan, J., Zhu, Z., Lu, J. and Wang, X. (2009). C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development 136(14): 2445-2455.
  13. Lu, Q., Zhang, Y., Hu, T., Guo, P., Li, W. and Wang, X. (2008). C. elegans Rab GTPase 2 is required for the degradation of apoptotic cells. Development 135(6): 1069-1080.
  14. Darland-Ransom, M., Wang, X., Sun, C. L., Mapes, J., Gengyo-Ando, K., Mitani, S. and Xue, D. (2008). Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science 320(5875): 528-531.
  15. Wang, X., Wang, J., Gengyo-Ando, K., Gu, L., Sun, C. L., Yang, C., Shi, Y., Kobayashi, T., Mitani, S., Xie, X. S. and Xue, D. (2007). C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol 9(5): 541-549.
  16. Wang, X., Wu, Y. C., Fadok, V. A., Lee, M. C., Gengyo-Ando, K., Cheng, L. C., Ledwich, D., Hsu, P. K., Chen, J. Y., Chou, B. K., Henson, P., Mitani, S. and Xue, D. (2003). Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 302(5650): 1563-1566.
  17. Wang X., Yang C., Cai J., Shi YG., Xue D. (2002) Mechanism of AIF mediated apoptosis in C. elegans. Science 298: 1587-1591(research article).
  18. Wang, X., Bauw, G., Van Damme, E. J., Peumans, W. J., Chen, Z. L., Van Montagu, M., Angenon, G. and Dillen, W. (2001). Gastrodianin-like mannose-binding proteins: a novel class of plant proteins with antifungal properties. Plant J 25(6): 651-661.
Protocols by Xiaochen Wang
  1. In vitro Lipid Binding Assay
  2. In vitro Lipid Transfer Assay
  3. Quantification of Cell Corpses, Cell Death Occurrence, Cell Corpse Duration