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Alfred J. Robison

Education

Ph.D. in Molecular Physiology and Biophysics, Vanderbilt University, USA, 2005

Current position

Assistant professor of Physiology and Neuroscience, Michigan State University, East Lansing, USA

Publications (since 2005)

  1. Iniguez, S. D., Riggs, L. M., Nieto, S. J., Wright, K. N., Zamora, N. N., Cruz, B., Zavala, A. R., Robison, A. J. and Mazei-Robison, M. S. (2015). Fluoxetine exposure during adolescence increases preference for cocaine in adulthood. Sci Rep 5: 15009.
  2. Eagle, A. L., Gajewski, P. A., Yang, M., Kechner, M. E., Al Masraf, B. S., Kennedy, P. J., Wang, H., Mazei-Robison, M. S. and Robison, A. J. (2015). Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning. J Neurosci 35(40): 13773-13783.
  3. Vialou, V., Thibault, M., Kaska, S., Cooper, S., Gajewski, P., Eagle, A., Mazei-Robison, M., Nestler, E. J. and Robison, A. J. (2015). Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress. Neuropharmacology 99: 28-37.
  4. Koo, J. W., Mazei-Robison, M. S., LaPlant, Q., Egervari, G., Braunscheidel, K. M., Adank, D. N., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D. M., Ribeiro, E., Pena, C. J., Walker, D., Bagot, R. C., Cahill, M. E., Anderson, S. A., Labonte, B., Hodes, G. E., Browne, H., Chadwick, B., Robison, A. J., Vialou, V. F., Dias, C., Lorsch, Z., Mouzon, E., Lobo, M. K., Dietz, D. M., Russo, S. J., Neve, R. L., Hurd, Y. L. and Nestler, E. J. (2015). Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci 18(3): 415-422.
  5. Carcea, I., Patil, S. B., Robison, A. J., Mesias, R., Huntsman, M. M., Froemke, R. C., Buxbaum, J. D., Huntley, G. W. and Benson, D. L. (2014). Maturation of cortical circuits requires Semaphorin 7A. Proc Natl Acad Sci U S A 111(38): 13978-13983.
  6. Cates, H. M., Thibault, M., Pfau, M., Heller, E., Eagle, A., Gajewski, P., Bagot, R., Colangelo, C., Abbott, T., Rudenko, G., Neve, R., Nestler, E. J. and Robison, A. J. (2014). Threonine 149 phosphorylation enhances ΔFosB transcriptional activity to control psychomotor responses to cocaine. J Neurosci 34(34): 11461-11469.
  7. Robison, A. J. (2014). Emerging role of CaMKII in neuropsychiatric disease. Trends Neurosci 37(11): 653-662.
  8. Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., Winstanley, C. A., Joshi, T., Feng, J., Berton, O. and Nestler, E. J. (2014). Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB. J Neurosci 34(11): 3878-3887.
  9. Robison, A. J., Vialou, V., Sun, H. S., Labonte, B., Golden, S. A., Dias, C., Turecki, G., Tamminga, C., Russo, S., Mazei-Robison, M. and Nestler, E. J. (2014). Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects. Neuropsychopharmacology 39(5): 1178-1186.
  10. Sanders, P. N., Koval, O. M., Jaffer, O. A., Prasad, A. M., Businga, T. R., Scott, J. A., Hayden, P. J., Luczak, E. D., Dickey, D. D., Allamargot, C., Olivier, A. K., Meyerholz, D. K., Robison, A. J., Winder, D. G., Blackwell, T. S., Dworski, R., Sammut, D., Wagner, B. A., Buettner, G. R., Pope, R. M., Miller, F. J., Jr., Dibbern, M. E., Haitchi, H. M., Mohler, P. J., Howarth, P. H., Zabner, J., Kline, J. N., Grumbach, I. M. and Anderson, M. E. (2013). CaMKII is essential for the proasthmatic effects of oxidation. Sci Transl Med 5(195): 195ra197.
  11. Kennedy, P. J., Feng, J., Robison, A. J., Maze, I., Badimon, A., Mouzon, E., Chaudhury, D., Damez-Werno, D. M., Haggarty, S. J., Han, M. H., Bassel-Duby, R., Olson, E. N. and Nestler, E. J. (2013). Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci 16(4): 434-440.
  12. Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., Kennedy, P. J., Robison, A. J., Gonzalez-Maeso, J., Neve, R. L., Turecki, G., Ghose, S., Tamminga, C. A. and Russo, S. J. (2013). Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nat Med 19(3): 337-344.
  13. Robison, A. J., Vialou, V., Mazei-Robison, M., Feng, J., Kourrich, S., Collins, M., Wee, S., Koob, G., Turecki, G., Neve, R., Thomas, M. and Nestler, E. J. (2013). Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. J Neurosci 33(10): 4295-4307.
  14. Grueter, B. A.*, Robison, A. J.*, Neve, R. L., Nestler, E. J. and Malenka, R. C. (2013). ΔFosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc Natl Acad Sci U S A 110(5): 1923-1928. (*Co First-Author)
  15. Klug, J. R., Mathur, B. N., Kash, T. L., Wang, H. D., Matthews, R. T., Robison, A. J., Anderson, M. E., Deutch, A. Y., Lovinger, D. M., Colbran, R. J. and Winder, D. G. (2012). Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS One 7(9): e45323.
  16. Vialou, V., Feng, J., Robison, A. J. and Nestler, E. J. (2013). Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol 53: 59-87.
  17. Vialou, V., Feng, J., Robison, A. J., Ku, S. M., Ferguson, D., Scobie, K. N., Mazei-Robison, M. S., Mouzon, E. and Nestler, E. J. (2012). Serum response factor and cAMP response element binding protein are both required for cocaine induction of ΔFosB. J Neurosci 32(22): 7577-7584.
  18. Mazei-Robison, M. S., Koo, J. W., Friedman, A. K., Lansink, C. S., Robison, A. J., Vinish, M., Krishnan, V., Kim, S., Siuta, M. A., Galli, A., Niswender, K. D., Appasani, R., Horvath, M. C., Neve, R. L., Worley, P. F., Snyder, S. H., Hurd, Y. L., Cheer, J. F., Han, M. H., Russo, S. J. and Nestler, E. J. (2011). Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 72(6): 977-990.
  19. Robison, A. J. and Nestler, E. J. (2011). Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12(11): 623-637.
  20. Muschamp, J. W., Nemeth, C. L., Robison, A. J., Nestler, E. J. and Carlezon, W. A., Jr. (2012). ΔFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biol Psychiatry 71(1): 44-50.
  21. Jiao, Y., Jalan-Sakrikar, N., Robison, A. J., Baucum, A. J., 2nd, Bass, M. A. and Colbran, R. J. (2011). Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation. J Biol Chem 286(28): 24806-24818.
  22. Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M. H., Ables, J. L., Eisch, A. J., Dietz, D. M., Ferguson, D., Neve, R. L., Greengard, P., Kim, Y., Morrison, J. H. and Russo, S. J. (2011). IkappaB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. J Neurosci 31(1): 314-321.
  23. Cao, J. L., Vialou, V. F., Lobo, M. K., Robison, A. J., Neve, R. L., Cooper, D. C., Nestler, E. J. and Han, M. H. (2010). Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. Proc Natl Acad Sci U S A 107(39): 17011-17016.
  24. Vialou, V., Robison, A. J., Laplant, Q. C., Covington, H. E., 3rd, Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., 3rd, Watts, E. L., Wallace, D. L., Iniguez, S. D., Ohnishi, Y. H., Steiner, M. A., Warren, B. L., Krishnan, V., Bolanos, C. A., Neve, R. L., Ghose, S., Berton, O., Tamminga, C. A. and Nestler, E. J. (2010). DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci 13(6): 745-752.
  25. Zhang, C., Atasoy, D., Arac, D., Yang, X., Fucillo, M. V., Robison, A. J., Ko, J., Brunger, A. T. and Sudhof, T. C. (2010). Neurexins physically and functionally interact with GABA(A) receptors. Neuron 66(3): 403-416.
  26. Renthal, W., Kumar, A., Xiao, G., Wilkinson, M., Covington, H. E., 3rd, Maze, I., Sikder, D., Robison, A. J., LaPlant, Q., Dietz, D. M., Russo, S. J., Vialou, V., Chakravarty, S., Kodadek, T. J., Stack, A., Kabbaj, M. and Nestler, E. J. (2009). Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 62(3): 335-348.
  27. Grueter, B. A., McElligott, Z. A., Robison, A. J., Mathews, G. C. and Winder, D. G. (2008). In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28(37): 9261-9270.
  28. Jiao, Y., Robison, A. J., Bass, M. A. and Colbran, R. J. (2008). Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. J Neurochem 105(5): 1746-1760.
  29. Robison, A. J., Winder, D. G., Colbran, R. J. and Bartlett, R. K. (2007). Oxidation of calmodulin alters activation and regulation of CaMKII. Biochem Biophys Res Commun 356(1): 97-101.
  30. Robison, A. J., Bartlett, R. K., Bass, M. A. and Colbran, R. J. (2005). Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin. J Biol Chem 280(47): 39316-39323.
  31. Robison, A. J., Bass, M. A., Jiao, Y., MacMillan, L. B., Carmody, L. C., Bartlett, R. K. and Colbran, R. J. (2005). Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. J Biol Chem 280(42): 35329-35336.
Protocols by Alfred J. Robison
  1. Sensitive Assessment of Hippocampal Learning Using Temporally Dissociated Passive Avoidance Task
  2. Sucrose Preference Test to Measure Stress-induced Anhedonia