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Markus H. Gräler

Education

Ph.D. in Biochemistry, Department of Biology, Chemistry, and Pharmacy, Free University Berlin, Germany, 2001

Current position

Professor of Sepsis Research, Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Germany

Publications (since 2013)

  1. Vettorazzi, S., Bode, C., Dejager, L., Frappart, L., Shelest, E., Klassen, C., Tasdogan, A., Reichardt, H. M., Libert, C., Schneider, M., Weih, F., Henriette Uhlenhaut, N., David, J. P., Gräler, M., Kleiman, A. and Tuckermann, J. P. (2015). Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun 6: 7796.
  2. Sattler, K., Gräler, M., Keul, P., Weske, S., Reimann, C. M., Jindrova, H., Kleinbongard, P., Sabbadini, R., Brocker-Preuss, M., Erbel, R., Heusch, G. and Levkau, B. (2015). Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content: Correction by Sphingosine-1-Phosphate-Loading. J Am Coll Cardiol 66(13): 1470-1485.
  3. Reimann, C. M., Thuy, A. V., Weigel, C. and Gräle, M. H. (2015). Sphingosine-1-phosphate (s1p) in cancer immunity and development. Transl Cancer Res 4:460-468.
  4. Lee, H. and Gräler, M. H. (2015). Lysophospholipid signaling in cancer and immunity at a glance. Transl Cancer Res 4:451-452.
  5. Nussbaum, C., Bannenberg, S., Keul, P., Gräler, M. H., Goncalves-de-Albuquerque, C. F., Korhonen, H., von Wnuck Lipinski, K., Heusch, G., de Castro Faria Neto, H. C., Rohwedder, I., Gothert, J. R., Prasad, V. P., Haufe, G., Lange-Sperandio, B., Offermanns, S., Sperandio, M. and Levkau, B. (2015). Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nat Commun 6: 6416.
  6. Bode, C., Berlin, M., Röstel, F., Teichmann, B. and Gräler, M. H. (2014). Evaluating sphingosine and its analogues as potential alternatives for aggressive lymphoma treatment. Cell Physiol Biochem 34(5): 1686-1700.
  7. Karaca, I., Tamboli, I. Y., Glebov, K., Richter, J., Fell, L. H., Grimm, M. O., Haupenthal, V. J., Hartmann, T., Gräler, M. H., van Echten-Deckert, G. and Walter, J. (2014). Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. J Biol Chem 289(24): 16761-16772.
  8. Sattler, K., Lehmann, I., Gräler, M., Brocker-Preuss, M., Erbel, R., Heusch, G. and Levkau, B. (2014). HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. Cell Physiol Biochem 34(1): 172-184.
  9. Thuy, A. V., Reimann, C. M., Hemdan, N. Y. and Gräler, M. H. (2014). Sphingosine 1-phosphate in blood: function, metabolism, and fate. Cell Physiol Biochem 34(1): 158-171.
  10. Dörr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Däbritz, J. H., Lisec, J., Lenze, D., Gerhardt, A., Schleicher, K., Kratzat, S., Purfurst, B., Walenta, S., Mueller-Klieser, W., Gräler, M., Hummel, M., Keller, U., Buck, A. K., Dorken, B., Willmitzer, L., Reimann, M., Kempa, S., Lee, S. and Schmitt, C. A. (2013). Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature 501(7467): 421-425.
Protocols by Markus H. Gräler
  1. Extraction and Quantification of Sphingosine 1-Phosphate (S1P)