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Tonya J. Webb

Education

Ph.D. in Microbiology and Immunology, Indiana University, in 2003.

Current position

Assistant Professor at the University of Maryland School of Medicine, and Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD USA

Publications (since 2005)

  1. East, J. E., Kennedy, A. J. and Webb, T. J. (2014). Raising the roof: the preferential pharmacological stimulation of Th1 and th2 responses mediated by NKT cells. Med Res Rev 34(1): 45-76.
  2. East, J. E., Sun, W. and Webb, T. J. (2012). Artificial antigen presenting cell (aAPC) mediated activation and expansion of natural killer T cells. J Vis Exp(70).
  3. Sun, W., Subrahmanyam, P. B., East, J. E. and Webb, T. J. (2012). Connecting the dots: artificial antigen presenting cell-mediated modulation of natural killer T cells. J Interferon Cytokine Res 32(11): 505-516.
  4. Webb, T. J., Li, X., Giuntoli, R. L., 2nd, Lopez, P. H., Heuser, C., Schnaar, R. L., Tsuji, M., Kurts, C., Oelke, M. and Schneck, J. P. (2012). Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer. Cancer Res 72(15): 3744-3752.
  5. Subrahmanyam, P. and Webb, T. J. (2012). Boosting the Immune Response: The Use of iNKT cell ligands as vaccine adjuvants. Front Biol (Beijing) 7(5): 436-444.
  6. Hua, J., Liang, S., Ma, X., Webb, T. J., Potter, J. P. and Li, Z. (2011). The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. PLoS ONE 6(11): e27038.
  7. Hua, J., Ma, X., Webb, T., Potter, J. J., Oelke, M. and Li, Z. (2010). Dietary fatty acids modulate antigen presentation to hepatic NKT cells in nonalcoholic fatty liver disease. J Lipid Res 51(7): 1696-1703.
  8. Giuntoli, R. L., 2nd, Webb, T. J., Zoso, A., Rogers, O., Diaz-Montes, T. P., Bristow, R. E. and Oelke, M. (2009). Ovarian cancer-associated ascites demonstrates altered immune environment: implications for antitumor immunity. Anticancer Res 29(8): 2875-2884.
  9. Webb, T. J., Bieler, J. G., Schneck, J. P. and Oelke, M. (2009). Ex vivo induction and expansion of natural killer T cells by CD1d1-Ig coated artificial antigen presenting cells. J Immunol Methods 346(1-2): 38-44.
  10. Webb, T. J., Giuntoli, R. L., 2nd, Rogers, O., Schneck, J. and Oelke, M. (2008). Ascites specific inhibition of CD1d-mediated activation of natural killer T cells. Clin Cancer Res 14(23): 7652-7658.
  11. Chiyo, M., Iwata, T., Webb, T. J., Vasko, M. R., Thompson, E. L., Heidler, K. M., Cummings, O. W., Yoshida, S., Fujisawa, T., Brand, D. D. and Wilkes, D. S. (2008). Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung. Am J Transplant 8(3): 537-546.
  12. Choi, K. S., Webb, T., Oelke, M., Scorpio, D. G. and Dumler, J. S. (2007). Differential innate immune cell activation and proinflammatory response in Anaplasma phagocytophilum infection. Infect Immun 75(6): 3124-3130.
  13. Hong, L., Webb, T. J. and Wilkes, D. S. (2007). Dendritic cell-T cell interactions: CD8 alpha alpha expressed on dendritic cells regulates T cell proliferation. Immunol Lett 108(2): 174-178.
  14. Webb, T. J., Litavecz, R. A., Khan, M. A., Du, W., Gervay-Hague, J., Renukaradhya, G. J. and Brutkiewicz, R. R. (2006). Inhibition of CD1d1-mediated antigen presentation by the vaccinia virus B1R and H5R molecules. Eur J Immunol 36(10): 2595-2600.
  15. Yoshida, S., Haque, A., Mizobuchi, T., Iwata, T., Chiyo, M., Webb, T. J., Baldridge, L. A., Heidler, K. M., Cummings, O. W., Fujisawa, T., Blum, J. S., Brand, D. D. and Wilkes, D. S. (2006). Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants. Am J Transplant 6(4): 724-735.
  16. Webb, T. J., Sumpter, T. L., Thiele, A. T., Swanson, K. A. and Wilkes, D. S. (2005). The phenotype and function of lung dendritic cells. Crit Rev Immunol 25(6): 465-491.
  17. Lin, Y., Roberts, T. J., Wang, C. R., Cho, S. and Brutkiewicz, R. R. (2005). Long-term loss of canonical NKT cells following an acute virus infection. Eur J Immunol 35(3): 879-889.
  18. Renukaradhya, G. J., Webb, T. J., Khan, M. A., Lin, Y. L., Du, W., Gervay-Hague, J. and Brutkiewicz, R. R. (2005). Virus-induced inhibition of CD1d1-mediated antigen presentation: reciprocal regulation by p38 and ERK. J Immunol 175(7): 4301-4308.
  19. Lin, Y., Roberts, T. J., Spence, P. M. and Brutkiewicz, R. R. (2005). Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection. J Leukoc Biol 77(2): 151-158.
Protocols by Tonya J. Webb
  1. Generation of Mouse iNKT Cell Lines
  2. Generation of Human iNKT Cell Lines