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Sabita Roy


Ph.D. in Neurobiology, University of Kansas, Lawrence, Kansas, USA

Current position

Professor and Vice Chair for Career Development,
Director, Division of Infection, Inflammation and Vascular Biology, Department of Surgery, University of Minnesota, Minneapolis, USA


  1. Jana, N., Vidhu, A., Raini, D., Zhang, L., Saluja, A., Meng, J., Lisa, K., Santanu, B. and Sabita, R. (2016). Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis. Sci Rep 6: 21094.
  2. Banerjee, S., Sindberg, G., Wang, F., Meng, J., Sharma, U., Zhang, L., Dauer, P., Chen, C., Dalluge, J., Johnson, T. and Roy, S. (2016). Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation. Mucosal Immunol.
  3. Chanakira, A., Kir, D., Barke, R. A., Santilli, S. M., Ramakrishnan, S. and Roy, S. (2015). Hypoxia Differentially Regulates Arterial and Venous Smooth Muscle Cell Migration. PLoS One 10(9): e0138587.
  4. Meng, J., Sindberg, G. M. and Roy, S. (2015). Disruption of gut homeostasis by opioids accelerates HIV disease progression. Front Microbiol 6: 643.
  5. Dutta, R. and Roy, S. (2015). Chronic morphine and HIV-1 Tat promote differential central nervous system trafficking of CD3+ and Ly6C+ immune cells in a murine Streptococcus pneumoniae infection model. J Neuroinflammation 12: 120.
  6. Banerjee, S., Ninkovic, J., Meng, J., Sharma, U., Ma, J., Charboneau, R. and Roy, S. (2015). Morphine compromises bronchial epithelial TLR2/IL17R signaling crosstalk, necessary for lung IL17 homeostasis. Sci Rep 5: 11384.
  7. Meng, J., Banerjee, S., Li, D., Sindberg, G. M., Wang, F., Ma, J. and Roy, S. (2015). Opioid Exacerbation of Gram-positive sepsis, induced by Gut Microbial Modulation, is Rescued by IL-17A Neutralization. Sci Rep 5: 10918.
  8. Sindberg, G. M., Sharma, U., Banerjee, S., Anand, V., Dutta, R., Gu, C. J., Volsky, D. J. and Roy, S. (2015). An infectious murine model for studying the systemic effects of opioids on early HIV pathogenesis in the gut. J Neuroimmune Pharmacol 10(1): 74-87.
  9. Ninković, J. and Roy, S. (2014). High throughput fluorometric technique for assessment of macrophage phagocytosis and actin polymerization. J Vis Exp(93): e52195.
  10. Koodie, L., Yuan, H., Pumper, J. A., Yu, H., Charboneau, R., Ramkrishnan, S. and Roy, S. (2014). Morphine inhibits migration of tumor-infiltrating leukocytes and suppresses angiogenesis associated with tumor growth in mice. Am J Pathol 184(4): 1073-1084.
  11. Ramakrishnan, S., Anand, V. and Roy, S. (2014). Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol 9(2): 142-160.
  12. Wan, J., Lata, C., Santilli, A., Green, D., Roy, S. and Santilli, S. (2014). Supplemental oxygen reverses hypoxia-induced smooth muscle cell proliferation by modulating HIF-alpha and VEGF levels in a rabbit arteriovenous fistula model. Ann Vasc Surg 28(3): 725-736.
  13. Meng, J., Yu, H., Ma, J., Wang, J., Banerjee, S., Charboneau, R., Barke, R. A. and Roy, S. (2013). Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner. PLoS One 8(1): e54040.
  14. Banerjee, S., Meng, J., Das, S., Krishnan, A., Haworth, J., Charboneau, R., Zeng, Y., Ramakrishnan, S. and Roy, S. (2013). Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a. Sci Rep 3: 1977.
  15. Dutta, R., Krishnan, A., Meng, J., Das, S., Ma, J., Banerjee, S., Wang, J., Charboneau, R., Prakash, O., Barke, R. A. and Roy, S. (2012). Morphine modulation of toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniae. J Neurosci 32(29): 9917-9930.
  16. Dutta, R. and Roy, S. (2012). Mechanism(s) involved in opioid drug abuse modulation of HAND. Curr HIV Res 10(5): 469-477.
  17. Ninkovic, J. and Roy, S. (2012). Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms. Am J Pathol 180(3): 1068-1079.
  18. Roy, S. (2011). Drugs of abuse effects on immunity and microbial pathogenesis. J Neuroimmune Pharmacol 6(4): 435-438.
  19. Ma, J., Wang, J., Wan, J., Charboneau, R., Chang, Y., Barke, R. A. and Roy, S. (2010). Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection. Infect Immun 78(2): 830-837.
Protocols by Sabita Roy
  1. Study of Epithelium Barrier Functions by Real-time TER Measurement