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Barbara Fazekas de St Groth

Education

Ph.D., University of Melbourne, 1986

Current position

Head of T Cell Biology Research Program, Centenary Institute, The University of Sydney, Sydney, Australia
Professor in Faculty of Medicine, The University of Sydney, Sydney, Australia
Director in Ramaciotti Facility for Human Systems Biology, The University of Sydney, Sydney, Australia

Publications(since 2005)

  1. Shklovskaya, E., Terry, A. M., Guy, T. V., Buckley, A., Bolton, H. A., Zhu, E., Holst, J. and Fazekas de St Groth, B. (2016). Tumour-specific CD4 T cells eradicate melanoma via indirect recognition of tumour-derived antigen. Immunol Cell Biol. (Epub ahead of print)
  2. Tiffen, J. C., Gallagher, S. J., Tseng, H. Y., Filipp, F. V., Fazekas de St Groth, B. and Hersey, P. (2016). EZH2 as a mediator of treatment resistance in melanoma. Pigment Cell Melanoma Res. (Epub ahead of print)
  3. Roediger, B., Kyle, R., Tay, S. S., Mitchell, A. J., Bolton, H. A., Guy, T. V., Tan, S. Y., Forbes-Blom, E., Tong, P. L., Köller, Y., Shklovskaya, E., Iwashima, M., McCoy, K. D., Le Gros, G., Fazekas de St Groth, B. and Weninger, W. (2015). IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation. J Allergy Clin Immunol 136(6): 1653-1663 e1651-1657.
  4. Bolton, H. A., Zhu, E., Terry, A. M., Guy, T. V., Koh, W. P., Tan, S. Y., Power, C. A., Bertolino, P., Lahl, K., Sparwasser, T., Shklovskaya, E. and Fazekas de St Groth, B. (2015). Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest 125(9): 3627-3641.
  5. Bolton, H. A., Roediger, B. and Fazekas de St Groth, B. (2015). The effects of IL-2 and Treg cells on dendritic cell homeostasis are mediated indirectly via activation of conventional T cells. Eur J Immunol 45(4): 1141-1147.
  6. Bolton, H. A., Zhu, E. H. and Fazekas de St Groth, B. (2015). Regulatory T cells fine-tune DC costimulation in vivo to set the threshold for T cell activation. In Proceedings of the 15th International Congress of Immunology: 25-28.
  7. Ochiai, S., Roediger, B., Abtin, A., Shklovskaya, E., Fazekas de St Groth, B., Yamane, H., Weninger, W., Le Gros, G. and Ronchese, F. (2014). CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice. J Immunol 193(5): 2504-2511.
  8. Hancock, D. G., Shklovskaya, E., Guy, T. V., Falsafi, R., Fjell, C. D., Ritchie, W., Hancock, R. E. and Fazekas de St Groth, B. (2014). A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells. PLoS One 9(6): e100613.
  9. Roediger, B., Kyle, R., Yip, K. H., Sumaria, N., Guy, T. V., Kim, B. S., Mitchell, A. J., Tay, S. S., Jain, R., Forbes-Blom, E., Chen, X., Tong, P. L., Bolton, H. A., Artis, D., Paul, W. E., Fazekas de St Groth, B., Grimbaldeston, M. A., Le Gros, G. and Weninger, W. (2013). Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol 14(6): 564-573.
  10. Hancock, D. G., Guy, T. V., Shklovskaya, E. and Fazekas de St Groth, B. (2013). Experimental models to investigate the function of dendritic cell subsets: challenges and implications. Clin Exp Immunol 171(2): 147-154.
  11. Tan, S. Y., Cavanagh, L. L., d'Advigor, W., Shackel, N., Fazekas de St Groth, B. and Weninger, W. (2012). Phenotype and functions of conventional dendritic cells are not compromised in aged mice. Immunol Cell Biol 90(7): 722-732.
  12. de St Groth, B. F. (2012). Regulatory T-cell abnormalities and the global epidemic of immuno-inflammatory disease. Immunol Cell Biol 90(3): 256-259.
  13. Sumaria, N., Roediger, B., Ng, L. G., Qin, J., Pinto, R., Cavanagh, L. L., Shklovskaya, E., Fazekas de St Groth, B., Triccas, J. A. and Weninger, W. (2011). Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells. J Exp Med 208(3): 505-518.
  14. Shklovskaya, E., O'Sullivan, B. J., Ng, L. G., Roediger, B., Thomas, R., Weninger, W. and Fazekas de St Groth, B. (2011). Langerhans cells are precommitted to immune tolerance induction. Proc Natl Acad Sci U S A 108(44): 18049-18054.
  15. Fazekas de St Groth, B., Zhu, E., Asad, S. and Lee, L. (2011). Flow cytometric detection of human regulatory T cells. Methods Mol Biol 707: 263-279.
  16. O'Sullivan, B. J., Pai, S., Street, S., An, X., MacDonald, K. P., Wong, M., Strutton, G., Gerondakis, S., Steptoe, R. J., de St Groth, B. F., Hill, G. R. and Thomas, R. (2011). Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation. J Immunol 187(8): 4018-4030.
  17. Santner-Nanan, B., Peek, M. J., Khanam, R., Richarts, L., Zhu, E., Fazekas de St Groth, B. and Nanan, R. (2009). Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol 183(11): 7023-7030.
  18. Ryan, A. A., Nambiar, J. K., Wozniak, T. M., Roediger, B., Shklovskaya, E., Britton, W. J., Fazekas de St Groth, B. and Triccas, J. A. (2009). Antigen load governs the differential priming of CD8 T cells in response to the bacille Calmette Guerin vaccine or Mycobacterium tuberculosis infection. J Immunol 182(11): 7172-7177.
  19. Shklovskaya, E., Roediger, B. and Fazekas de St Groth, B. (2008). Epidermal and dermal dendritic cells display differential activation and migratory behavior while sharing the ability to stimulate CD4+ T cell proliferation in vivo. J Immunol 181(1): 418-430.
  20. Santner-Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., Fazekas de St Groth, B. and Nanan, R. (2008). Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. Int Immunol 20(3): 375-383.
  21. Roediger, B., Ng, L. G., Smith, A. L., Fazekas de St Groth, B. and Weninger, W. (2008). Visualizing dendritic cell migration within the skin. Histochem Cell Biol 130(6): 1131-1146.
  22. Fazekas de St Groth, B. and Landay, A. L. (2008). Regulatory T cells in HIV infection: pathogenic or protective participants in the immune response? AIDS 22(6): 671-683.
  23. Basten, A. and Fazekas de St Groth, B. (2008). Special regulatory T-cell review: T-cell dependent suppression revisited. Immunology 123(1): 33-39.
  24. Triccas, J. A., Shklovskaya, E., Spratt, J., Ryan, A. A., Palendira, U., Fazekas de St Groth, B. and Britton, W. J. (2007). Effects of DNA- and Mycobacterium bovis BCG-based delivery of the Flt3 ligand on protective immunity to Mycobacterium tuberculosis. Infect Immun 75(11): 5368-5375.
  25. Shklovskaya, E. and Fazekas de St Groth, B. (2007). Balancing tolerance and immunity: the role of dendritic cell and T cell subsets. Methods Mol Biol 380: 25-46.
  26. Ryan, A. A., Wozniak, T. M., Shklovskaya, E., O'Donnell, M. A., Fazekas de St Groth, B., Britton, W. J. and Triccas, J. A. (2007). Improved protection against disseminated tuberculosis by Mycobacterium bovis bacillus Calmette-Guerin secreting murine GM-CSF is associated with expansion and activation of APCs. J Immunol 179(12): 8418-8424.
  27. Fazekas de St Groth, B. (2007). Regulatory T-cell function: when suppressor cells can't suppress. Immunol Cell Biol 85(3): 179-181.
  28. Tan, S. Y., Bolton, H., Mouawad, M., Roediger, B., Power, C., Koh, W. P., Yagita, H., Shklovskaya, E. and Fazekas de St Groth, B. (2007). Enhanced T cell proliferation in lymphopenic mice is driven by over-expression of costimulatory molecules by dendritic cells. unpublished data.
  29. Seddiki, N., Tan, S. Y., Smialkowski, A., Gorter, M., Dervish, S., Selby, W., Solomon, M., Lee, S., McKenzie, P. and Fazekas de St Groth, B. (2007). Young patients with inflammatory bowel disease display primary deficits in naive regulatory T cells. unpublished data.
  30. Zaunders, J. J., Ip, S., Munier, M. L., Kaufmann, D. E., Suzuki, K., Brereton, C., Sasson, S. C., Seddiki, N., Koelsch, K., Landay, A., Grey, P., Finlayson, R., Kaldor, J., Rosenberg, E. S., Walker, B. D., Fazekas de St Groth, B., Cooper, D. A. and Kelleher, A. D. (2006). Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection. J Virol 80(20): 10162-10172.
  31. Shklovskaya, E. and Fazekas de St Groth, B. (2006). Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: role of T cell antigen receptor and IL-7 receptor signals. J Immunol 177(12): 8320-8330.
  32. Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., Kelleher, A. and Fazekas de St Groth, B. (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203(7): 1693-1700.
  33. Maekawa, A., Schmidt, B., Fazekas de St Groth, B., Sanejouand, Y. H. and Hogg, P. J. (2006). Evidence for a domain-swapped CD4 dimer as the coreceptor for binding to class II MHC. J Immunol 176(11): 6873-6878.
  34. Liu, W., Putnam, A. L., Xu-Yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., Fazekas de St Groth, B., Clayberger, C., Soper, D. M., Ziegler, S. F. and Bluestone, J. A. (2006). CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203(7): 1701-1711.
  35. Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R. and Fazekas de Saint Groth, B. (2006). Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 107(7): 2830-2838.
  36. Harris, N. L., Holloway, J., Fitzharris, P., McDonald, M., Camberis, M., Fazekas de St Groth, B., Ronchese, F. and Le Gros, G. (2005). Tissue localization and frequency of antigen-specific effector CD4 T cells determines the development of allergic airway inflammation. Immunol Cell Biol 83(5): 490-497.
  37. Goodnow, C. C., Sprent, J., Fazekas de St Groth, B. and Vinuesa, C. G. (2005). Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435(7042): 590-597.
  38. Gaus, K., Chklovskaia, E., Fazekas de St Groth, B., Jessup, W. and Harder, T. (2005). Condensation of the plasma membrane at the site of T lymphocyte activation. J Cell Biol 171(1): 121-131.
Protocols by Barbara Fazekas de St Groth
  1. Reconstitution of Lymphopaenic Mice with Regulatory and Conventional T cell Subsets