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Javier Traba

Education

Ph.D., Molecular Biology, Centro de Biología Molecular Severo Ochoa (UAM/CSIC), Universidad Autónoma de Madrid, Madrid, Spain, 2009

Current position

Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute (NHLBI, NIH), Bethesda, MD

Publications

  1. Rueda, C. B.*, Traba, J.*, Amigo, I.*, Llorente-Folch, I., Gonzalez-Sanchez, P., Pardo, B., Esteban, J. A., del Arco, A. and Satrustegui, J. (2015). Mitochondrial ATP-Mg/Pi carrier SCaMC-3/Slc25a23 counteracts PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons. J Neurosci 35(8): 3566-3581. (* Equal contribution)
  2. Traba, J., Kwarteng-Siaw, M., Okoli, T. C., Li, J., Huffstutler, R. D., Bray, A., Waclawiw, M. A., Han, K., Pelletier, M., Sauve, A. A., Siegel, R. M. and Sack, M. N. (2015). Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects. J Clin Invest 125(12): 4592-4600.
  3. Webster, B. R., Scott, I., Traba, J., Han, K. and Sack, M. N. (2014). Regulation of autophagy and mitophagy by nutrient availability and acetylation. Biochim Biophys Acta 1841(4): 525-534.
  4. Pla-Martin, D., Rueda, C. B., Estela, A., Sanchez-Piris, M., Gonzalez-Sanchez, P., Traba, J., de la Fuente, S., Scorrano, L., Renau-Piqueras, J., Alvarez, J., Satrustegui, J. and Palau, F. (2013). Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry. Neurobiol Dis 55: 140-151.
  5. Amigo, I., Traba, J., Gonzalez-Barroso, M. M., Rueda, C. B., Fernandez, M., Rial, E., Sanchez, A., Satrustegui, J. and Del Arco, A. (2013). Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. J Biol Chem 288(11): 7791-7802.
  6. Amigo, I., Traba, J., Satrustegui, J. and del Arco, A. (2012). SCaMC-1Like a member of the mitochondrial carrier (MC) family preferentially expressed in testis and localized in mitochondria and chromatoid body. PLoS One 7(7): e40470.
  7. Traba, J., Del Arco, A., Duchen, M. R., Szabadkai, G. and Satrustegui, J. (2012). SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. Cell Death Differ 19(4): 650-660.
  8. Traba, J.1, Satrustegui, J. and del Arco, A. (2011). Adenine nucleotide transporters in organelles: novel genes and functions. Cell Mol Life Sci 68(7): 1183-1206. (1Corresponding author)
  9. Traba, J.1, Satrustegui, J. and del Arco, A. (2009). Transport of adenine nucleotides in the mitochondria of Saccharomyces cerevisiae: interactions between the ADP/ATP carriers and the ATP-Mg/Pi carrier. Mitochondrion 9(2): 79-85. (1Corresponding author)
  10. Traba, J., Satrustegui, J. and del Arco, A. (2009). Characterization of SCaMC-3-like/slc25a41, a novel calcium-independent mitochondrial ATP-Mg/Pi carrier. Biochem J 418(1): 125-133.
  11. Traba, J., Froschauer, E. M., Wiesenberger, G., Satrustegui, J. and Del Arco, A. (2008). Yeast mitochondria import ATP through the calcium-dependent ATP-Mg/Pi carrier Sal1p, and are ATP consumers during aerobic growth in glucose. Mol Microbiol 69(3): 570-585.
  12. Cavero, S.*, Traba, J.*, Del Arco, A. and Satrustegui, J. (2005). The calcium-dependent ATP-Mg/Pi mitochondrial carrier is a target of glucose-induced calcium signalling in Saccharomyces cerevisiae. Biochem J 392(Pt 3): 537-544. (* Equal contribution)
Protocols by Javier Traba
  1. Isolating Liver Mitochondria by Differential Centrifugation
  2. Isolating Brain Mitochondria by Differential Centrifugation