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Javier E. Irazoqui

Education

Ph.D. in Cell Biology, Duke University Medical Center, Durham NC, 2003

Current position

Assistant Professor, Department of Pediatrics, Harvard Medical School

Associate Immunologist, Department of Pediatrics, Massachusetts General Hospital

Publications

Peer-reviewed articles
Note: Underlining indicates Irazoqui lab members.

  1. Visvikis, O., Ihuegbu, N., Luhachack, L.G., Alves, A. F., Wollenberg, A.C., Labed, S., Stormo, G. D. and Irazoqui, J. E. (2013). Innate Host Defense Requires TFEB-mediated Transcription of Cytoprotective and Antimicrobial Genes. Cell  Under review
  2. Lapierre, L. R., De Magalhaes Filho, C. D., McQuary, P. R., Chu, C. C., Visvikis, O., Chang, J. T., Gelino, S., Ong, B., Davis, A. E., Irazoqui, J. E., Dillin, A. and Hansen, M. (2013). The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun 4: 2267.
  3. Settembre, C., De Cegli, R.*, Mansueto, G., Saha, P. K.*, Vetrini, F.*, Visvikis, O.*, Huynh, T., Carissimo, A., Palmer, D., Klisch, T. J., Wollenberg, A. C., Di Bernardo, D., Chan, L., Irazoqui, J. E. and Ballabio, A. (2013). TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol 15(6): 647-658. *equal contributors
  4. Brown, S., Xia, G., Luhachack, L.G., Campbell, J., Meredith, T. C., Chen, C., Winstel V, Gekelerb C, Irazoqui J.E, Peschel, A. and Walker, S. (2012). Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids. Proc Natl Acad Sci U S A 109(46): 18909-18914.
  5. Luhachack, L.G., Visvikis, O., Wollenberg, A.C., Lacy-Hulbert, A., Stuart, L.M., and Irazoqui, J.E. (2012). EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways. PLoS Pathog 8(7): e1002798.
  6. Wahlby, C., Kamentsky, L., Liu, Z. H., Riklin-Raviv, T., Conery, A. L., O'Rourke, E. J., Sokolnicki, K. L., Visvikis, O., Ljosa, V., Irazoqui, J. E., Golland, P., Ruvkun, G., Ausubel, F. M. and Carpenter, A. E. (2012). An image analysis toolbox for high-throughput C. elegans assays. Nat Methods 9(7): 714-716.
  7. Irazoqui, J. E.*, Troemel, E. R., Feinbaum, R. L., Luhachack, L. G., Cezairliyan, B. O. and Ausubel, F. M. (2010). Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog 6: e1000982. *Corresponding author.
  8. Irazoqui, J. E., Urbach, J. M. and Ausubel, F. M. (2010). Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates. Nat Rev Immunol 10(1): 47-58.
  9. Irazoqui, J. E., Ng, A., Xavier, R. J. and Ausubel, F. M. (2008). Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Proc Natl Acad Sci U S A 105(45): 17469-17474.
  10. Irazoqui, J. E., Howell, A. S., Theesfeld, C. L. and Lew, D. J. (2005). Opposing roles for actin in Cdc42p polarization. Mol Biol Cell 16(3): 1296-1304.
    Featured in the American Society for Cell Biology Newsletter.
    Nominee for Best Paper of the Year 2005 by the American Society for Cell Biology. Rated “Must Read” by Faculty of 1000.
  11. Irazoqui, J. E., Gladfelter, A. S. and Lew, D. J. (2003). Scaffold-mediated symmetry breaking by Cdc42p. Nat Cell Biol 5(12): 1062-1070.
    Featured in News & Views, Nat Cell Biol. 2003 Dec;5(12):1048-9.
    Rated “Must Read” by Faculty of 1000.
  12. Bose, I.*, Irazoqui, J. E.*, Moskow, J. J., Bardes, E. S., Zyla, T. R. and Lew, D. J. (2001). Assembly of scaffold-mediated complexes containing Cdc42p, the exchange factor Cdc24p, and the effector Cla4p required for cell cycle-regulated phosphorylation of Cdc24p. J Biol Chem 276(10): 7176-7186. *Co-first authors
  13. Theesfeld, C. L.*, Irazoqui, J. E.*, Bloom, K. and Lew, D. J. (1999). The role of actin in spindle orientation changes during the Saccharomyces cerevisiae cell cycle. J Cell Biol 146(5): 1019-1032. *Co-first authors

Non peer-reviewed articles

  1. Irazoqui, J. E. (2011). Transparent worms help survey the fortress of innate immunity. Virulence 2(2): 83-85.
  2. Irazoqui, J. E. and Ausubel, F. M. (2010). 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Caenorhabditis elegans as a model to study tissues involved in host immunity and microbial pathogenesis. Clin Exp Immunol 160(1): 48-57.
  3. Irazoqui, J. E., Gladfelter, A. S. and Lew, D. J. (2004). Cdc42p, GTP hydrolysis, and the cell's sense of direction. Cell Cycle 3(7): 861-864
  4. Irazoqui, J. E. and Lew, D. J. (2004). Polarity establishment in yeast. J Cell Sci 117(Pt 11): 2169-2171.
Protocols by Javier E. Irazoqui
  1. Staphylococcus aureus Killing Assay of Caenorhabditis elegans