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Félix Bonilla


Ph. D. in Medicine, Oncologist

Current position

Section Chief in Medical Oncology, Hospital Puerta de Hierro, Madrid, Spain

Publications (since 2010)

  1. Soldevilla, B., Rodriguez, M., San Millan, C., Garcia, V., Fernandez-Perianez, R., Gil-Calderon, B., Martin, P., Garcia-Grande, A., Silva, J., Bonilla, F. and Dominguez, G. (2014). Tumor-derived exosomes are enriched in DeltaNp73, which promotes oncogenic potential in acceptor cells and correlates with patient survival. Hum Mol Genet 23(2): 467-478.
  2. Herrera, A., Herrera, M., Alba-Castellon, L., Silva, J., Garcia, V., Loubat-Casanovas, J., Alvarez-Cienfuegos, A., Miguel Garcia, J., Rodriguez, R., Gil, B., Ma Jesus, C., Ma Jesus, L., Ignacio Casal, J., de Herreros, A. G., Bonilla, F. and Pena, C. (2014). Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells. Int J Cancer 134(12): 2984-2990.
  3. Rodriguez, M., Silva, J., Lopez-Alfonso, A., Lopez-Muniz, M. B., Pena, C., Dominguez, G., Garcia, J. M., Lopez-Gonzalez, A., Mendez, M., Provencio, M., Garcia, V. and Bonilla, F. (2014). Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer. Genes Chromosomes Cancer 53(9): 713-724.
  4. Larriba, M. J., Gonzalez-Sancho, J. M., Bonilla, F. and Munoz, A. (2014). Interaction of vitamin D with membrane-based signaling pathways. Front Physiol 5: 60.
  5. Batlle, R., Alba-Castellon, L., Loubat-Casanovas, J., Armenteros, E., Franci, C., Stanisavljevic, J., Banderas, R., Martin-Caballero, J., Bonilla, F., Baulida, J., Casal, J. I., Gridley, T. and Garcia de Herreros, A. (2013). Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells. Oncogene 32(28): 3381-3389.
  6. Urdinguio, R. G., Fernandez, A. F., Moncada-Pazos, A., Huidobro, C., Rodriguez, R. M., Ferrero, C., Martinez-Camblor, P., Obaya, A. J., Bernal, T., Parra-Blanco, A., Rodrigo, L., Santacana, M., Matias-Guiu, X., Soldevilla, B., Dominguez, G., Bonilla, F., Cal, S., Lopez-Otin, C. and Fraga, M. F. (2013). Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res 73(1): 395-405.
  7. Herrera, M., Herrera, A., Dominguez, G., Silva, J., Garcia, V., Garcia, J. M., Gomez, I., Soldevilla, B., Munoz, C., Provencio, M., Campos-Martin, Y., Garcia de Herreros, A., Casal, I., Bonilla, F. and Pena, C. (2013). Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer Sci 104(4): 437-444.
  8. Pelaez-Garcia, A., Barderas, R., Torres, S., Hernandez-Varas, P., Teixido, J., Bonilla, F., de Herreros, A. G. and Casal, J. I. (2013). FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer. PLoS One 8(5): e63695.
  9. Barderas, R., Mendes, M., Torres, S., Bartolome, R. A., Lopez-Lucendo, M., Villar-Vazquez, R., Pelaez-Garcia, A., Fuente, E., Bonilla, F. and Casal, J. I. (2013). In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion. Mol Cell Proteomics 12(6): 1602-1620.
  10. Soldevilla, B., Millan, C. S., Bonilla, F. and Dominguez, G. (2013). The TP73 complex network: ready for clinical translation in cancer? Genes Chromosomes Cancer 52(11): 989-1006.
  11. Herrera, M., Islam, A. B., Herrera, A., Martin, P., Garcia, V., Silva, J., Garcia, J. M., Salas, C., Casal, I., de Herreros, A. G., Bonilla, F. and Pena, C. (2013). Functional heterogeneity of cancer-associated fibroblasts from human colon tumors shows specific prognostic gene expression signature. Clin Cancer Res 19(21): 5914-5926.
  12. Torres, S., Bartolome, R. A., Mendes, M., Barderas, R., Fernandez-Acenero, M. J., Pelaez-Garcia, A., Pena, C., Lopez-Lucendo, M., Villar-Vazquez, R., de Herreros, A. G., Bonilla, F. and Casal, J. I. (2013). Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res 19(21): 6006-6019.
  13. Rodriguez, R. M., Huidobro, C., Urdinguio, R. G., Mangas, C., Soldevilla, B., Dominguez, G., Bonilla, F., Fernandez, A. F. and Fraga, M. F. (2012). Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer. J Mol Med (Berl) 90(5): 587-595.
  14. Barderas, R., Babel, I., Diaz-Uriarte, R., Moreno, V., Suarez, A., Bonilla, F., Villar-Vazquez, R., Capella, G. and Casal, J. I. (2012). An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays. J Proteomics 75(15): 4647-4655.
  15. Silva, J., Garcia, V., Rodriguez, M., Compte, M., Cisneros, E., Veguillas, P., Garcia, J. M., Dominguez, G., Campos-Martin, Y., Cuevas, J., Pena, C., Herrera, M., Diaz, R., Mohammed, N. and Bonilla, F. (2012). Analysis of exosome release and its prognostic value in human colorectal cancer. Genes Chromosomes Cancer 51(4): 409-418.
  16. Alvarez-Diaz, S., Valle, N., Ferrer-Mayorga, G., Lombardia, L., Herrera, M., Dominguez, O., Segura, M. F., Bonilla, F., Hernando, E. and Munoz, A. (2012). MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. Hum Mol Genet 21(10): 2157-2165.
  17. Silva, J., Garcia, V., Zaballos, A., Provencio, M., Lombardia, L., Almonacid, L., Garcia, J. M., Dominguez, G., Pena, C., Diaz, R., Herrera, M., Varela, A. and Bonilla, F. (2011). Vesicle-related microRNAs in plasma of nonsmall cell lung cancer patients and correlation with survival. Eur Respir J 37(3): 617-623.
  18. Mohammed, N., Rodriguez, M., Garcia, V., Garcia, J. M., Dominguez, G., Pena, C., Herrera, M., Gomez, I., Diaz, R., Soldevilla, B., Herrera, A., Silva, J. and Bonilla, F. (2011). EPAS1 mRNA in plasma from colorectal cancer patients is associated with poor outcome in advanced stages. Oncol Lett 2(4): 719-724.
  19. Soldevilla, B., Diaz, R., Silva, J., Campos-Martin, Y., Munoz, C., Garcia, V., Garcia, J. M., Pena, C., Herrera, M., Rodriguez, M., Gomez, I., Mohamed, N., Marques, M. M., Bonilla, F. and Dominguez, G. (2011). Prognostic impact of DeltaTAp73 isoform levels and their target genes in colon cancer patients. Clin Cancer Res 17(18): 6029-6039.
  20. Gomez, I., Pena, C., Herrera, M., Munoz, C., Larriba, M. J., Garcia, V., Dominguez, G., Silva, J., Rodriguez, R., Garcia de Herreros, A., Bonilla, F. and Garcia, J. M. (2011). TWIST1 is expressed in colorectal carcinomas and predicts patient survival. PLoS One 6(3): e18023.
  21. Pereira, F., Barbachano, A., Silva, J., Bonilla, F., Campbell, M. J., Munoz, A. and Larriba, M. J. (2011). KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Hum Mol Genet 20(23): 4655-4665.
  22. Vinas-Castells, R., Beltran, M., Valls, G., Gomez, I., Garcia, J. M., Montserrat-Sentis, B., Baulida, J., Bonilla, F., de Herreros, A. G. and Diaz, V. M. (2010). The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem 285(6): 3794-3805.
  23. Ordonez-Moran, P., Alvarez-Diaz, S., Valle, N., Larriba, M. J., Bonilla, F. and Munoz, A. (2010). The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling. J Steroid Biochem Mol Biol 121(1-2): 355-361.
  24. Larriba, M. J., Bonilla, F. and Munoz, A. (2010). The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression. J Steroid Biochem Mol Biol 121(1-2): 106-109.
  25. Barbachano, A., Ordonez-Moran, P., Garcia, J. M., Sanchez, A., Pereira, F., Larriba, M. J., Martinez, N., Hernandez, J., Landolfi, S., Bonilla, F., Palmer, H. G., Rojas, J. M. and Munoz, A. (2010). SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. Oncogene 29(34): 4800-4813.
  26. Diaz, R., Gonzalez-Sancho, J. M., Soldevilla, B., Silva, J., Garcia, J. M., Garcia, V., Pena, C., Herrera, M., Gomez, I., Bonilla, F. and Dominguez, G. (2010). Differential regulation of TP73 isoforms by 1alpha,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas. Genes Chromosomes Cancer 49(12): 1135-1142.
Protocols by Félix Bonilla
  1. Colon Cancer-associated Fibroblast Establishment and Culture Growth