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Antonio García de Herreros

Education

Ph.D. in Biochemistry, Centro de Biologia Molecular, Universidad Autónoma de Madrid 1985

Current position

Senior Scientist, Insititut Hospital del Mar d’Investigació Mèdica: Professor of Biochemistry, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

Publications

  1. Loubat-Casanovas, J., Pena, R., Gonzalez, N., Alba-Castellon, L., Rosell, S., Franci, C., Navarro, P. and Garcia de Herreros, A. (2016). Snail1 is required for the maintenance of the pancreatic acinar phenotype. Oncotarget 7(4): 4468-4482.
  2. Beltran, M., Aparicio-Prat, E., Mazzolini, R., Millanes-Romero, A., Masso, P., Jenner, R. G., Diaz, V. M., Peiro, S. and de Herreros, A. G. (2015). Splicing of a non-coding antisense transcript controls LEF1 gene expression. Nucleic Acids Res 43(12): 5785-5797.
  3. Frias, A., Lambies, G., Vinas-Castells, R., Martinez-Guillamon, C., Dave, N., Garcia de Herreros, A.* and Diaz, V. M.* (2015). A Switch in Akt Isoforms Is Required for Notch-Induced Snail1 Expression and Protection from Cell Death. Mol Cell Biol 36(6): 923-940. (*Corresponding authors)
  4. Vinas-Castells, R., Frias, A., Robles-Lanuza, E., Zhang, K., Longmore, G. D., Garcia de Herreros, A.* and Diaz, V. M.* (2014). Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. Nucleic Acids Res 42(2): 1079-1094. (*Corresponding authors)
  5. Vinyoles, M., Del Valle-Perez, B., Curto, J., Vinas-Castells, R., Alba-Castellon, L., Garcia de Herreros, A.* and Dunach, M.* (2014). Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6. Mol Cell 53(3): 444-457.
  6. Batlle, R., Alba-Castellon, L., Loubat-Casanovas, J., Armenteros, E., Franci, C., Stanisavljevic, J., Banderas, R., Martin-Caballero, J., Bonilla, F., Baulida, J., Casal, J. I., Gridley, T. and Garcia de Herreros, A. (2013). Snail1 controls TGF-beta responsiveness and differentiation of mesenchymal stem cells. Oncogene 32(28): 3381-3389.
  7. Villagrasa, P., Diaz, V. M., Vinas-Castells, R., Peiro, S., Del Valle-Perez, B., Dave, N., Rodriguez-Asiain, A., Casal, J. I., Lizcano, J. M., Dunach, M.* and Garcia de Herreros, A.* (2012). Akt2 interacts with Snail1 in the E-cadherin promoter. Oncogene 31(36): 4022-4033. (*Corresponding authors)
  8. Dave, N., Guaita-Esteruelas, S., Gutarra, S., Frias, A., Beltran, M., Peiro, S. and de Herreros, A. G. (2011). Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem 286(14): 12024-12032.
  9. Del Valle-Perez, B., Casagolda, D., Lugilde, E., Valls, G., Codina, M., Dave, N., de Herreros, A. G.* and Dunach, M.* (2011). Wnt controls the transcriptional activity of Kaiso through CK1epsilon-dependent phosphorylation of p120-catenin. J Cell Sci 124(Pt 13): 2298-2309. (*Corresponding authors)
  10. Del Valle-Perez, B., Arques, O., Vinyoles, M., de Herreros, A. G.* and Dunach, M.* (2011). Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol 31(14): 2877-2888. (*Corresponding authors)
  11. Beltran, M., Puig, I., Pena, C., Garcia, J. M., Alvarez, A. B., Pena, R., Bonilla, F. and de Herreros, A. G. (2008). A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev 22(6): 756-769.
  12. Piedra, J., Miravet, S., Castano, J., Palmer, H. G., Heisterkamp, N., Garcia de Herreros, A.* and Dunach, M.* (2003). p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol 23(7): 2287-2297. (*Corresponding authors)
  13. Guaita, S., Puig, I., Franci, C., Garrido, M., Dominguez, D., Batlle, E., Sancho, E., Dedhar, S., De Herreros, A. G.* and Baulida, J.* (2002). Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 277(42): 39209-39216. (*Corresponding authors)
  14. Batlle, E., Sancho, E., Franci, C., Dominguez, D., Monfar, M., Baulida, J. and Garcia De Herreros, A. (2000). The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2(2): 84-89.
  15. Roura, S., Miravet, S., Piedra, J., Garcia de Herreros, A.* and Dunach, M.* (1999). Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J Biol Chem 274(51): 36734-36740. (*Corresponding authors)
Protocols by Antonio García de Herreros
  1. Colon Cancer-associated Fibroblast Establishment and Culture Growth