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Serge Laroche

Education

Ph.D. in Neuroscience, University Paris VI, France

Current position

Director of Research at CNRS, Paris-Saclay Neuroscience Institute, University Paris-Sud, France
Director of the NeuroMem Research Group, CNRS Unit GDR 2905

Publications

  1. Veyrac, A., Allerborn, M., Gros, A., Michon, F., Raguet, L., Kenney, J., Godinot, F., Thevenet, M., Garcia, S., Messaoudi, B., Laroche, S. and Ravel, N. (2015). Memory of occasional events in rats: individual episodic memory profiles, flexibility, and neural substrate. J Neurosci 35(19): 7575-7586.
  2. Miranda, R., Nagapin, F., Bozon, B., Laroche, S., Aubin, T. and Vaillend, C. (2015). Altered social behavior and ultrasonic communication in the dystrophin-deficient mdx mouse model of Duchenne muscular dystrophy. Mol Autism 6: 60.
  3. Veyrac, A., Besnard, A., Caboche, J., Davis, S. and Laroche, S. (2014). The transcription factor Zif268/Egr1, brain plasticity, and memory. Prog Mol Biol Transl Sci 122: 89-129.
  4. Veyrac, A., Gros, A., Bruel-Jungerman, E., Rochefort, C., Kleine Borgmann, F. B., Jessberger, S. and Laroche, S. (2013). Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by learning. Proc Natl Acad Sci U S A 110(17): 7062-7067.3
  5. Morice, E., Farley, S., Poirier, R., Dallerac, G., Chagneau, C., Pannetier, S., Hanauer, A., Davis, S., Vaillend, C. and Laroche, S. (2013). Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome. Neurobiol Dis 58: 156-168.
  6. Besnard, A., Laroche, S. and Caboche, J. (2014). Comparative dynamics of MAPK/ERK signalling components and immediate early genes in the hippocampus and amygdala following contextual fear conditioning and retrieval. Brain Struct Funct 219(1): 415-430.
  7. Perronnet, C., Chagneau, C., Le Blanc, P., Samson-Desvignes, N., Mornet, D., Laroche, S., De La Porte, S. and Vaillend, C. (2012). Upregulation of brain utrophin does not rescue behavioral alterations in dystrophin-deficient mice. Hum Mol Genet 21(10): 2263-2276.
  8. Besnard, A., Caboche, J. and Laroche, S. (2012). Reconsolidation of memory: a decade of debate. Prog Neurobiol 99(1): 61-80.
  9. Miranda, R., Nudel, U., Laroche, S. and Vaillend, C. (2011). Altered presynaptic ultrastructure in excitatory hippocampal synapses of mice lacking dystrophins Dp427 or Dp71. Neurobiol Dis 43(1): 134-141.
  10. Dallerac, G., Perronnet, C., Chagneau, C., Leblanc-Veyrac, P., Samson-Desvignes, N., Peltekian, E., Danos, O., Garcia, L., Laroche, S., Billard, J. M. and Vaillend, C. (2011). Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse. Neurobiol Dis 43(3): 635-641.
  11. Vaillend, C., Perronnet, C., Ros, C., Gruszczynski, C., Goyenvalle, A., Laroche, S., Danos, O., Garcia, L. and Peltekian, E. (2010). Rescue of a dystrophin-like protein by exon skipping in vivo restores GABAA-receptor clustering in the hippocampus of the mdx mouse. Mol Ther 18(9): 1683-1688.
  12. Renaudineau, S., Poucet, B., Laroche, S., Davis, S. and Save, E. (2009). Impaired long-term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1. Proc Natl Acad Sci U S A 106(28): 11771-11775.
  13. Bruel-Jungerman, E., Veyrac, A., Dufour, F., Horwood, J., Laroche, S. and Davis, S. (2009). Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus. PLoS One 4(11): e7901.
  14. Miranda, R., Sebrie, C., Degrouard, J., Gillet, B., Jaillard, D., Laroche, S. and Vaillend, C. (2009). Reorganization of inhibitory synapses and increased PSD length of perforated excitatory synapses in hippocampal area CA1 of dystrophin-deficient mdx mice. Cereb Cortex 19(4): 876-888.
  15. Bruel-Jungerman, E., Davis, S., Rampon, C. and Laroche, S. (2006). Long-term potentiation enhances neurogenesis in the adult dentate gyrus. J Neurosci 26(22): 5888-5893.
  16. Bliss, T. V., Collingridge, G. L. and Laroche, S. (2006). Neuroscience. ZAP and ZIP, a story to forget. Science 313(5790): 1058-1059.
  17. Kelly, A., Laroche, S. and Davis, S. (2003). Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory. J Neurosci 23(12): 5354-5360.
  18. Bozon, B., Davis, S. and Laroche, S. (2003). A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. Neuron 40(4): 695-701.
  19. Bozon, B., Kelly, A., Josselyn, S. A., Silva, A. J., Davis, S. and Laroche, S. (2003). MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos Trans R Soc Lond B Biol Sci 358(1432): 805-814.
  20. Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T. V., Garel, S., Charnay, P., Bozon, B., Laroche, S. and Davis, S. (2001). A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci 4(3): 289-296.
  21. Davis, S., Vanhoutte, P., Pages, C., Caboche, J. and Laroche, S. (2000). The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J Neurosci 20(12): 4563-4572.
  22. Stephan, A., Laroche, S. and Davis, S. (2001). Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits. J Neurosci 21(15): 5703-5714.
  23. Errington, M. L., Bliss, T. V., Morris, R. J., Laroche, S. and Davis, S. (1997). Long-term potentiation in awake mutant mice. Nature 387(6634): 666-667.
  24. Thomas, K. L., Laroche, S., Errington, M. L., Bliss, T. V. and Hunt, S. P. (1994). Spatial and temporal changes in signal transduction pathways during LTP. Neuron 13(3): 737-745.
  25. Smirnova, T., Laroche, S., Errington, M. L., Hicks, A. A., Bliss, T. V. and Mallet, J. (1993). Transsynaptic expression of a presynaptic glutamate receptor during hippocampal long-term potentiation. Science 262(5132): 433-436.
Protocols by Serge Laroche
  1. A Novel Task for Studying Memory of Occasional Events in Rats