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Steve Jean


Ph.D. in Molecular and Cell Biology, Laval University, Québec, Canada, 2008

Current position

Assistant Professor, Department of Anatomy and Cell Biology, Université de Sherbrooke, Sherbrooke, Canada


  1. Jean, S., Cox, S., Nassari, S. and Kiger, A. A. (2015). Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. EMBO Rep 16(3): 297-311.
  2. Jean, S. and Kiger, A. A. (2014). Classes of phosphoinositide 3-kinases at a glance. J Cell Sci 127(Pt 5): 923-928.
  3. Jean, S. and Kiger, A. A. (2012). Coordination between RAB GTPase and phosphoinositide regulation and functions. Nat Rev Mol Cell Biol 13(7): 463-470.
  4. Jean, S., Cox, S., Schmidt, E. J., Robinson, F. L. and Kiger, A. (2012). Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol Biol Cell 23(14): 2723-2740.
  5. Jean, S., Tremblay, M. G., Herdman, C., Guillou, F. and Moss, T. (2012). The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling. Biol Open 1(8): 731-738.
  6. Jean, S., Mikryukov, A., Tremblay, M. G., Baril, J., Guillou, F., Bellenfant, S. and Moss, T. (2010). Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo. Dev Cell 19(3): 426-439.
  7. Velichkova, M., Juan, J., Kadandale, P., Jean, S., Ribeiro, I., Raman, V., Stefan, C. and Kiger, A. A. (2010). Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. J Cell Biol 190(3): 407-425.
  8. Jean, S. and Moss, T. (2008). A ubiquitin-conjugating enzyme, ube2d3.2, regulates xMLK2 and pronephros formation in Xenopus. Differentiation 76(4): 431-441.
  9. Bisson, N., Islam, N., Poitras, L., Jean, S., Bresnick, A. and Moss, T. (2003). The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events. Dev Biol 263(2): 264-281.
  10. Poitras, L., Jean, S., Islam, N. and Moss, T. (2003). PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase. FEBS Lett 543(1-3): 129-135.
Protocols by Steve Jean
  1. RAB21 Activity Assay Using GST-fused APPL1
  2. VAMP8-3xHA Uptake Assay in HeLa Cells