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Kevin P. O’Rourke

Kevin P. O’Rourke


B.A. in Molecular Biology and Biochemistry, Middlebury College, 2009

Current position

M.D.-Ph.D. Student at the Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional M.D.-Ph.D. Program

Publications (since 2005)

  1. Lindemans, C. A., Calafiore, M., Mertelsmann, A. M., O'Connor, M. H., Dudakov, J. A., Jenq, R. R., Velardi, E., Young, L. F., Smith, O. M., Lawrence, G., Ivanov, J. A., Fu, Y. Y., Takashima, S., Hua, G., Martin, M. L., O'Rourke, K. P., Lo, Y. H., Mokry, M., Romera-Hernandez, M., Cupedo, T., Dow, L. E., Nieuwenhuis, E. E., Shroyer, N. F., Liu, C., Kolesnick, R., van den Brink, M. R. and Hanash, A. M. (2015). Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature 528(7583): 560-564.
  2. Dow, L. E.*, O'Rourke, K. P.*, Simon, J., Tschaharganeh, D. F., van Es, J. H., Clevers, H. and Lowe, S. W. (2015). Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell 161(7): 1539-1552. *Co-first authors. (With cover photo)
  3. Dow, L. E., Fisher, J., O'Rourke, K. P., Muley, A., Kastenhuber, E. R., Livshits, G., Tschaharganeh, D. F., Socci, N. D. and Lowe, S. W. (2015). Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol 33(4): 390-394.
  4. Ganem, N. J., Cornils, H., Chiu, S. Y., O'Rourke, K. P., Arnaud, J., Yimlamai, D., Thery, M., Camargo, F. D. and Pellman, D. (2014). Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell 158(4): 833-848.
  5. O'Rourke, K. P., Shaw, J. D., Pesesky, M. W., Cook, B. T., Roberts, S. M., Bond, J. P. and Spatafora, G. A. (2010). Genome-wide characterization of the SloR metalloregulome in Streptococcus mutans. J Bacteriol 192(5): 1433-1443. (With cover photo)
Protocols by Kevin P. O’Rourke
  1. Immunofluorescent Staining of Mouse Intestinal Stem Cells
  2. Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells