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Richard M. Higashi

Education

Ph.D. in Environmental chemistry, University of California, Davis, 1987

Current position

Professor, Department of Toxicology & Cancer Biology, University of Kentucky (2013-present)
Co-director, Center Environmental Systems Biochemistry (2014-present)

Publications

  1. Sellers, K., Fox, M. P., Bousamra, M., 2nd, Slone, S. P., Higashi, R. M., Miller, D. M., Wang, Y., Yan, J., Yuneva, M. O., Deshpande, R., Lane, A. N.* and Fan, T. W.* (2015). Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest 125(2): 687-698.
  2. Liu, M., Luo, F., Ding, C., Albeituni, S., Hu, X., Ma, Y., Cai, Y., McNally, L., Sanders, M. A., Jain, D., Kloecker, G., Bousamra, M., 2nd, Zhang, H. G., Higashi, R. M., Lane, A. N., Fan, T. W. and Yan, J. (2015). Dectin-1 Activation by a Natural Product beta-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype. J Immunol 195(10): 5055-5065.
  3. Xie, H., Hanai, J., Ren, J. G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K. J., Grant, A., Wang, X., Lorkiewicz, P. K., Schatzman, S., Bousamra, M., 2nd, Lane, A. N., Higashi, R. M., Fan, T. W., Pandolfi, P. P., Sukhatme, V. P. and Seth, P. (2014). Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab 19(5): 795-809.
  4. Le, A., Lane, A. N., Hamaker, M., Bose, S., Barbi, J., Tsukamoto, T., Rojas, C. J., Slusher, B. S., Zhang, H., Zimmerman. L. J., Liebler, D. C., Slebos, R. J. C., Lorkiewicz, P. K., Higashi, R. M., Fan, T. W. M. and Dang, C. V. (2012). Myc induction of hypoxic glutamine metabolism and a glucose-independent TCA cycle in human B lymphocytes. Cell Metab 15: 110-121.
  5. Yuneva, M. O., Fan, T. W., Allen, T. D., Higashi, R. M., Ferraris, D. V., Tsukamoto, T., Mates, J. M., Alonso, F. J., Wang, C., Seo, Y., Chen, X. and Bishop, J. M. (2012). The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab 15(2): 157-170
  6. Fan, T. W., Lane, A. N., Higashi, R. M. and Yan, J. (2011). Stable isotope resolved metabolomics of lung cancer in a SCID mouse model. Metabolomics 7(2): 257-269.
  7. Moseley, H. N., Lane, A. N., Belshoff, A. C., Higashi, R. M. and Fan, T. W. (2011). A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on (13)C mass isotopologue profiles under non-steady-state conditions. BMC Biol 9: 37.
  8. Fan, T. W., Lane, A. N., Higashi, R. M., Farag, M. A., Gao, H., Bousamra, M. and Miller, D. M. (2009). Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8: 41.
  9. Fan, T. W., Yuan, P., Lane, A. N., Higashi, R. M., Wang, Y., Hamidi, A. B., Zhou, R., Guitart, X., Chen, G., Manji, H. K. and Kaddurah-Daouk, R. (2010). Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions. Metabolomics 6(2): 165-179.
  10. Lane, A. N., Fan, T. W., Xie, Z., Moseley, H. N. and Higashi, R. M. (2009). Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR. Anal Chim Acta 651(2): 201-208.
  11. Fan, T. W., Lane, A. N., Higashi, R. M., Farag, M. A., Gao, H., Bousamra, M. and Miller, D. M. (2009). Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8: 41.
  12. Fan, T. W., Higashi, R. M. and Lane, A. N. (2006). Integrating metabolomics and transcriptomics for probing SE anticancer mechanisms. Drug Metab Rev 38(4): 707-732.

Protocols by Richard M. Higashi
  1. Stable Isotope Resolved Metabolomics Studies in ex vivo TIssue Slices