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Akinori  Takaoka

Akinori Takaoka

Education

Ph.D in Internal Medicine, Sapporo Medical University, Graduate School of Medicine, Japan, 1996
M.D in Internal Medicine, Sapporo Medical University, Japan,1992

Current position

Management Council Member, Hokkaido University
Professor, Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University

Publications

  1. Yamada, T., Horimoto, H., Kameyama, T., Hayakawa, S., Yamato, H., Dazai, M., Takada, A., Kida, H., Bott, D., Zhou, A. C., Hutin, D., Watts, T. H., Asaka, M., Matthews, J. and Takaoka, A. (2016). Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense. Nat Immunol 17(6): 687-694.
  2. Sato, S., Li, K., Kameyama, T., Hayashi, T., Ishida, Y., Murakami, S., Watanabe, T., Iijima, S., Sakurai, Y., Watashi, K., Tsutsumi, S., Sato, Y., Akita, H., Wakita, T., Rice, C. M., Harashima, H., Kohara, M., Tanaka, Y. and Takaoka, A. (2015). The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus. Immunity 42(1): 123-132.
  3. Bhattacharya, A., Hegazy, A. N., Deigendesch, N., Kosack, L., Cupovic, J., Kandasamy, R. K., Hildebrandt, A., Merkler, D., Kuhl, A. A., Vilagos, B., Schliehe, C., Panse, I., Khamina, K., Baazim, H., Arnold, I., Flatz, L., Xu, H. C., Lang, P. A., Aderem, A., Takaoka, A., Superti-Furga, G., Colinge, J., Ludewig, B., Lohning, M. and Bergthaler, A. (2015). Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity 43(5): 974-986.
  4. Ingle, H., Kumar, S., Raut, A. A., Mishra, A., Kulkarni, D. D., Kameyama, T., Takaoka, A., Akira, S. and Kumar, H. (2015). The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication. Sci Signal 8(406): ra126.
  5. Kumar, S., Ingle, H., Mishra, S., Mahla, R. S., Kumar, A., Kawai, T., Akira, S., Takaoka, A., Raut, A. A. and Kumar, H. (2015). IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity. Cell Death Dis 6:e1758
  6. Kawata, K., Iwai, A., Muramatsu, D., Aoki, S., Uchiyama, H., Okabe, M., Hayakawa, S., Takaoka, A. and Miyazaki, T. (2015). Stimulation of macrophages with the beta-glucan produced by aureobasidium pullulans promotes the secretion of tumor necrosis factor-related apoptosis inducing ligand (TRAIL). PLoS One 10(4): e0124809.
  7. Ito, K., Morimoto, J., Kihara, A., Matsui, Y., Kurotaki, D., Kanayama, M., Simmons, S., Ishii, M., Sheppard, D., Takaoka, A. and Uede, T. (2014). Integrin alpha9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A 111(8): 3080-3085.
  8. Nakagawa, S., Hirata, Y., Kameyama, T., Tokunaga, Y., Nishito, Y., Hirabayashi, K., Yano, J., Ochiya, T., Tateno, C., Tanaka, Y., Mizokami, M., Tsukiyama-Kohara, K., Inoue, K., Yoshiba, M., Takaoka, A. and Kohara, M. (2013). Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. PLoS One 8:e59611.
  9. Jinushi, M., Chiba, S., Baghdadi, M., Kinoshita, I., Dosaka-Akita, H., Ito, K., Yoshiyama, H., Yagita, H., Uede, T. and Takaoka, A. (2012). ATM-mediated DNA damage signals mediate immune escape through integrin-alphavbeta3-dependent mechanisms. Cancer Res 72(1): 56-65.
  10. Jinushi, M., Chiba, S., Yoshiyama, H., Masutomi, K., Kinoshita, I., Dosaka-Akita, H., Yagita, H., Takaoka, A. and Tahara, H. (2011). Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci U S A 108(30): 12425-12430.
  11. Sasaki, S., Ishida, T., Toyota, M., Ota, A., Suzuki, H., Takaoka, A., Yasui, H., Yamamoto, H., Takagi, H., Maeda, M., Seito, T., Tsujisaki, M., Shinomura, Y. and Imai, K. (2011). Interferon-alpha/beta and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo. PLoS One 6(5): e19618.
  12. Tsushima, K., Osawa, T., Yanai, H., Nakajima, A., Takaoka, A., Manabe, I., Ohba, Y., Imai, Y., Taniguchi, T. and Nagai, R. (2011). IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension. FASEB J 25(5): 1531-1543.
  13. Hayakawa, S., Shiratori, S., Yamato, H., Kameyama, T., Kitatsuji, C., Kashigi, F., Goto, S., Kameoka, S., Fujikura, D., Yamada, T., Mizutani, T., Kazumata, M., Sato, M., Tanaka, J., Asaka, M., Ohba, Y., Miyazaki, T., Imamura, M. and Takaoka, A. (2011). ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. Nat Immunol 12(1): 37-44.
  14. Chen, H. M., Tanaka, N., Mitani, Y., Oda, E., Nozawa, H., Chen, J. Z., Yanai, H., Negishi, H., Choi, M. K., Iwasaki, T., Yamamoto, H., Taniguchi, T. and Takaoka, A. (2009). Critical role for constitutive type I interferon signaling in the prevention of cellular transformation. Cancer Sci 100(3): 449-456.
  15. Takaoka, A. and Taniguchi, T. (2008). Cytosolic DNA recognition for triggering innate immune responses. Adv Drug Deliv Rev 60(7): 847-857.
  16. Wang, Z., Choi, M. K., Ban, T., Yanai, H., Negishi, H., Lu, Y., Tamura, T., Takaoka, A., Nishikura, K. and Taniguchi, T. (2008). Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules. Proc Natl Acad Sci U S A 105(14): 5477-5482.
  17. Takaoka, A., Tamura1, T. and Taniguchi1, T. (2008). IRF family of transcription factors and regulation of oncogenesis. Cancer Sci 99: 467-478.
  18. Yanai, H., Chen, H. M., Inuzuka, T., Kondo, S., Mak, T. W., Takaoka, A., Honda, K. and Taniguchi, T. (2007). Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci U S A 104(9): 3402-3407.
  19. Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., Ohba, Y. and Taniguchi, T. (2007). DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448(7152): 501-505.
  20. Imai, K. and Takaoka, A. (2006). Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6(9): 714-727.
  21. Takaoka, A. and Yanai, H. (2006). Interferon signalling network in innate defence. Cell Microbiol 8(6): 907-922.
  22. Shibue, T., Suzuki, S., Okamoto, H., Yoshida, H., Ohba, Y., Takaoka, A. and Taniguchi, T. (2006). Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways. EMBO J 25(20): 4952-4962.
  23. Takaoka, A. and Yanai, H. (2006). Interferon signalling network in innate defence. Cell Microbiol 8(6): 907-922.
  24. Takaoka, A., Yanai, H., Kondo, S., Duncan, G., Negishi, H., Mizutani, T., Kano, S., Honda, K., Ohba, Y., Mak, T. W. and Taniguchi, T. (2005). Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434(7030): 243-249.
  25. Taniguchi, T. and Takaoka, A. (2005). Type I interferon system and IRF family of transcription factors in host defense regulation. Proc Jpn Acad Ser B 81: 1-13.
  26. Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C. and Taniguchi, T. (2005). Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type I interferon induction. Nature 434: 1035-1040.
  27. Takayanagi, H., Sato, K., Takaoka, A. and Taniguchi, T. (2005). Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev 208: 181-193.
  28. Negishi, H., Ohba, Y., Yanai, H., Takaoka, A., Honma, K., Yui, K., Matsuyama, T., Taniguchi, T. and Honda, K. (2005). Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-15994.
  29. Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N. and Taniguchi, T. (2005). IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434(7034): 772-777.
  30. Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Yeh, W. C. and Taniguchi, T. (2004). Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A 101(43): 15416-15421.
  31. Takaoka, A., Hayakawa, S., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Sasaki, S., Imai, K., Shibue, T., Honda, K. and Taniguchi, T. (2003). Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence. Nature 424(6948): 516-523.
  32. Takaoka, A. and Taniguchi, T. (2003). New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism. Cancer Sci 94(5): 405-411.
  33. Shibue, T., Takeda, K., Oda, E., Tanaka, H., Murasawa, H., Takaoka, A., Morishita, Y., Akira, S., Taniguchi, T. and Tanaka, N. (2003). Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17(18): 2233-2238.
  34. Honda, K., Sakaguchi, S., Nakajima, C., Watanabe, A., Yanai, H., Matsumoto, M., Ohteki, T., Kaisho, T., Takaoka, A., Akira, S., Seya, T. and Taniguchi, T. (2003). Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A 100(19): 10872-10877.
  35. Taniguchi, T. and Takaoka, A. (2002). The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 14(1): 111-116.
  36. Taniguchi, T., Ogasawara, K., Takaoka, A. and Tanaka, N. (2001). IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19: 623-655.
  37. Taniguchi, T. and Takaoka, A. (2001). A weak signal for strong responses: interferon-alpha/beta revisited. Nat Rev Mol Cell Biol 2(5): 378-386.
  38. Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., Nakamura, K. and Taniguchi, T. (2000). T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408(6812): 600-605.
  39. Tsujino, S., Di Santo, J. P., Takaoka, A., McKernan, T. L., Noguchi, S., Taya, C., Yonekawa, H., Saito, T., Taniguchi, T. and Fujii, H. (2000). Differential requirement of the cytoplasmic subregions of γc chain in T cell development and function. Proc Natl Acad Sci U S A 97: 10514-10519.
  40. Takaoka, A., Mitani, Y., Suemori, H., Sato, M., Yokochi, T., Noguchi, S., Tanaka, N. and Taniguchi, T. (2000). Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains. Science 288(5475): 2357-2360.
Protocols by Akinori Takaoka
  1. HBV Infection in Human Hepatocytes and Quantification of Encapsidated HBV DNA
  2. Infection of Human Hepatocyte-Chimeric Mice with HBV and in vivo Treatment with εRNA
  3. In vitro Treatment of Mouse and Human Cells with Endogenous Ligands for Activation of the Aryl Hydrocarbon Receptor
  4. FICZ Exposure and Viral Infection in Mice