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Serge Rivest

Education

Ph.D. in Physiology-Endocrinology, Université Laval, 1990

Current position

Director, CHU de Québec Research Center, Centre de Recherche du CHU de Québec, Québec (09/2012-present)

Publications

Refereed Papers, published or in press

  1. Larochelle, A., Bellavance, M. A., Michaud, J. P. and Rivest, S. (2015). Bone marrow-derived macrophages and the CNS: An update on the use of experimental chimeric mouse models and bone marrow transplantation in neurological disorders. Biochim Biophys Acta. [Epub ahead of print]
  2. ElAli, A., Bordeleau, M., Theriault, P., Filali, M., Lampron, A. and Rivest, S. (2015). Tissue-Plasminogen Activator Attenuates Alzheimer's Disease-Related Pathology Development in APPswe/PS1 Mice. Neuropsychopharmacology. [Epub ahead of print]
  3. ElAli, A. and Rivest, S. (2015). Microglia in Alzheimer's disease: A multifaceted relationship. Brain Behav Immun.
  4. Rivest, S. (2015). CX3CR1 in multiple sclerosis. Oncotarget 6(24): 19946-19947. [Epub ahead of print]
  5. Theriault, P., ElAli, A. and Rivest, S. (2015). The dynamics of monocytes and microglia in Alzheimer's disease. Alzheimers Res Ther 7(1): 41.
  6. Rivest, S. (2015). TREM2 enables amyloid beta clearance by microglia. Cell Res 25(5): 535-536.
  7. Lampron, A., Larochelle, A., Laflamme, N., Prefontaine, P., Plante, M. M., Sanchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M. E. and Rivest, S. (2015). Inefficient clearance of myelin debris by microglia impairs remyelinating processes. J Exp Med 212(4): 481-495.
  8. Larochelle, A., Bellavance, M. A. and Rivest, S. (2015). Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity. Brain Behav Immun 46: 221-231.
  9. Pimentel-Coelho, P. M., Michaud, J. P. and Rivest, S. (2015). C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits. Behav Brain Res 286: 146-151.
  10. Michaud, J. P. and Rivest, S. (2015). Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology. Neuron 85(3): 450-452.
  11. Doring, A., Sloka, S., Lau, L., Mishra, M., van Minnen, J., Zhang, X., Kinniburgh, D., Rivest, S. and Yong, V. W. (2015). Stimulation of monocytes, macrophages, and microglia by amphotericin B and macrophage colony-stimulating factor promotes remyelination. J Neurosci 35(3): 1136-1148.
  12. Audoy-Remus, J., Bozoyan, L., Dumas, A., Filali, M., Lecours, C., Lacroix, S., Rivest, S., Tremblay, M. E. and Vallieres, L. (2015). GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease. Brain Behav Immun 46: 112-120.
  13. Bellavance, M. A., Gosselin, D., Yong, V. W., Stys, P. K. and Rivest, S. (2015). Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain Struct Funct 220(3): 1759-1776.
  14. Michaud, J. P., Pimentel-Coelho, P. M., Tremblay, Y. and Rivest, S. (2014). The impact of Ly6Clow monocytes after cerebral hypoxia-ischemia in adult mice. J Cereb Blood Flow Metab 34(7): e1-9.
  15. ElAli, A., Theriault, P. and Rivest, S. (2014). The role of pericytes in neurovascular unit remodeling in brain disorders. Int J Mol Sci 15(4): 6453-6474.
  16. Bellavance, M. A. and Rivest, S. (2014). The HPA - Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain. Front Immunol 5: 136.
  17. Strachan-Whaley, M., Rivest, S. and Yong, V. W. (2014). Interactions between microglia and T cells in multiple sclerosis pathobiology. J Interferon Cytokine Res 34(8): 615-622.
  18. Lim, T. K., Shi, X. Q., Martin, H. C., Huang, H., Luheshi, G., Rivest, S. and Zhang, J. (2014). Blood-nerve barrier dysfunction contributes to the generation of neuropathic pain and allows targeting of injured nerves for pain relief. Pain 155(5): 954-967.
  19. Michaud, J. P., Bellavance, M. A., Prefontaine, P. and Rivest, S. (2013). Real-time in vivo imaging reveals the ability of monocytes to clear vascular amyloid beta. Cell Rep 5(3): 646-653.
  20. ElAli, A., Theriault, P., Prefontaine, P. and Rivest, S. (2013). Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation. Acta Neuropathol Commun 1: 75.
  21. Schwartz, M., Kipnis, J., Rivest, S. and Prat, A. (2013). How do immune cells support and shape the brain in health, disease, and aging? J Neurosci 33(45): 17587-17596.
  22. Liesz, A., Zhou, W., Na, S. Y., Hammerling, G. J., Garbi, N., Karcher, S., Mracsko, E., Backs, J., Rivest, S. and Veltkamp, R. (2013). Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. J Neurosci 33(44): 17350-17362.
  23. Naert, G. and Rivest, S. (2013). A deficiency in CCR2+ monocytes: the hidden side of Alzheimer's disease. J Mol Cell Biol 5(5): 284-293.
  24. Pimentel-Coelho, P. M., Michaud, J. P. and Rivest, S. (2013). Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury. J Neurosci 33(28): 11556-11572.
  25. Lampron, A., Pimentel-Coelho, P. M. and Rivest, S. (2013). Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration. J Comp Neurol 521(17): 3863-3876. Cover page in J Comp Neurol. 2013 Dec 1;521(17):Spc1. doi: 10.1002/cne.23463.
  26. Lampron, A., Elali, A. and Rivest, S. (2013). Innate immunity in the CNS: redefining the relationship between the CNS and Its environment. Neuron 78(2): 214-232.
  27. Michaud, J. P., Halle, M., Lampron, A., Theriault, P., Prefontaine, P., Filali, M., Tribout-Jover, P., Lanteigne, A. M., Jodoin, R., Cluff, C., Brichard, V., Palmantier, R., Pilorget, A., Larocque, D. and Rivest, S. (2013). Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A 110(5): 1941-1946.
    *Research Highlight, Nature Reviews Neurology 9, 120 (March 2013) doi:10.1038/nrneurol.2013.15
  28. Elali, A. and Rivest, S. (2013). The role of ABCB1 and ABCA1 in beta-amyloid clearance at the neurovascular unit in Alzheimer's disease. Front Physiol 4: 45.
  29. Gosselin, D., Bellavance, M. A. and Rivest, S. (2013). IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults. Front Cell Neurosci 7: 9.
  30. Belzil, C., Neumayer, G., Vassilev, A. P., Yap, K. L., Konishi, H., Rivest, S., Sanada, K., Ikura, M., Nakatani, Y. and Nguyen, M. D. (2013). A Ca2+-dependent mechanism of neuronal survival mediated by the microtubule-associated protein p600. J Biol Chem 288(34): 24452-24464.
  31. Pimentel-Coelho, P. M., Michaud, J. P. and Rivest, S. (2013). Effects of mild chronic cerebral hypoperfusion and early amyloid pathology on spatial learning and the cellular innate immune response in mice. Neurobiol Aging 34(3): 679-693.
  32. Boivin, N., Menasria, R., Piret, J., Rivest, S. and Boivin, G. (2013). The combination of valacyclovir with an anti-TNF alpha antibody increases survival rate compared to antiviral therapy alone in a murine model of herpes simplex virus encephalitis. Antiviral Res 100(3): 649-653.
  33. Naert, G. and Rivest, S. (2012). Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice. Front Cell Neurosci 6: 51.
  34. Lecours, M. P., Segura, M., Fittipaldi, N., Rivest, S. and Gottschalk, M. (2012). Immune receptors involved in Streptococcus suis recognition by dendritic cells. PLoS One 7(9): e44746.
  35. Lau, L. W., Keough, M. B., Haylock-Jacobs, S., Cua, R., Doring, A., Sloka, S., Stirling, D. P., Rivest, S. and Yong, V. W. (2012). Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination. Ann Neurol 72(3): 419-432.
  36. Kang, J. and Rivest, S. (2012). Lipid metabolism and neuroinflammation in Alzheimer's disease: a role for liver X receptors. Endocr Rev 33(5): 715-746.
  37. Bellavance, M. A. and Rivest, S. (2012). The neuroendocrine control of the innate immune system in health and brain diseases. Immunol Rev 248(1): 36-55.
  38. Pimentel-Coelho, P. M. and Rivest, S. (2012). The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer's disease. Eur J Neurosci 35(12): 1917-1937.
  39. Michaud, J. P., Richard, K. L. and Rivest, S. (2012). Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease. Stem Cell Rev 8(3): 898-904.
  40. Boivin, N., Menasria, R., Gosselin, D., Rivest, S. and Boivin, G. (2012). Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis. J Gen Virol 93(Pt 6): 1294-1304.
  41. Naert, G. and Rivest, S. (2012). Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Mol Med 18: 297-313.
  42. Lampron, A., Lessard, M. and Rivest, S. (2012). Effects of myeloablation, peripheral chimerism, and whole-body irradiation on the entry of bone marrow-derived cells into the brain. Cell Transplant 21(6): 1149-1159.
  43. Gosselin, D. and Rivest, S. (2011). Estrogen receptor transrepresses brain inflammation. Cell 145(4): 495-497.
  44. Echeverry, S., Shi, X. Q., Rivest, S. and Zhang, J. (2011). Peripheral nerve injury alters blood-spinal cord barrier functional and molecular integrity through a selective inflammatory pathway. J Neurosci 31(30): 10819-10828.
  45. Nadeau, S., Filali, M., Zhang, J., Kerr, B. J., Rivest, S., Soulet, D., Iwakura, Y., de Rivero Vaccari, J. P., Keane, R. W. and Lacroix, S. (2011). Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1beta and TNF: implications for neuropathic pain. J Neurosci 31(35): 12533-12542.
  46. Gosselin, D. and Rivest, S. (2011). Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis. Neurotherapeutics 8(4): 643-649.
  47. Rivest, S. (2011). The promise of anti-inflammatory therapies for CNS injuries and diseases. Expert Rev Neurother 11(6): 783-786.
  48. Naert, G. and Rivest, S. (2011). CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. J Neurosci 31(16): 6208-6220.
  49. Michaud, J. P., Richard, K. L. and Rivest, S. (2011). MyD88-adaptor protein acts as a preventive mechanism for memory deficits in a mouse model of Alzheimer's disease. Mol Neurodegener 6(1): 5.
  50. Filali, M., Lalonde, R. and Rivest, S. (2011). Sensorimotor and cognitive functions in a SOD1(G37R) transgenic mouse model of amyotrophic lateral sclerosis. Behav Brain Res 225(1): 215-221.
  51. Naert, G. and Rivest, S. (2011). The role of microglial cell subsets in Alzheimer's disease. Curr Alzheimer Res 8(2): 151-155.
  52. Filali, M., Lalonde, R. and Rivest, S. (2011). Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease. Physiol Behav 104(5): 880-885.
  53. Filali, M., Lalonde, R. and Rivest, S. (2011). Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer's disease. Neuropharmacology 60(6): 930-936.
  54. Lampron, A., Gosselin, D. and Rivest, S. (2011). Targeting the hematopoietic system for the treatment of Alzheimer's disease. Brain Behav Immun 25 Suppl 1: S71-79.
  55. Zheng, H., Punaro, M. C., Segura, M., Lachance, C., Rivest, S., Xu, J., Houde, M. and Gottschalk, M. (2011). Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis. J Neuroimmunol 234(1-2): 71-83.
  56. Glezer, I. and Rivest, S. (2010). Oncostatin M is a novel glucocorticoid-dependent neuroinflammatory factor that enhances oligodendrocyte precursor cell activity in demyelinated sites. Brain Behav Immun 24(5): 695-704.
  57. Yong, V. W. and Rivest, S. (2009). Taking advantage of the systemic immune system to cure brain diseases. Neuron 64(1): 55-60.
  58. Glezer, I., Bittencourt, J. C. and Rivest, S. (2009). Neuronal expression of Cd36, Cd44, and Cd83 antigen transcripts maps to distinct and specific murine brain circuits. J Comp Neurol 517(6): 906-924.
  59. Naert, G., Laflamme, N. and Rivest, S. (2009). Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain. J Innate Immun 1(5): 480-493.
  60. Rivest, S. (2009). Regulation of innate immune responses in the brain. Nat Rev Immunol 9(6): 429-439.
  61. Smith, D. E., Lipsky, B. P., Russell, C., Ketchem, R. R., Kirchner, J., Hensley, K., Huang, Y., Friedman, W. J., Boissonneault, V., Plante, M. M., Rivest, S. and Sims, J. E. (2009). A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity 30(6): 817-831.
  62. Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T. and Veltkamp, R. (2009). Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med 15(2): 192-199. News and Views on the paper Nature Medicine 15(2): 138-139, 2009. (Featured on the cover)
  63. Boissonneault, V., Filali, M., Lessard, M., Relton, J., Wong, G. and Rivest, S. (2009). Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain 132(Pt 4): 1078-1092. Editorial, 132(4):825-826, 2009.
  64. Boissonneault, V., Plante, I., Rivest, S. and Provost, P. (2009). MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 284(4): 1971-1981. Publication recommended by the Faculty of 1000 Biology (http://www.f1000biology.com)
  65. Filali, M., Lalonde, R. and Rivest, S. (2009). Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav 8(2): 143-148.
  66. Dominguez-Punaro Mde, L., Segura, M., Radzioch, D., Rivest, S. and Gottschalk, M. (2008). Comparison of the susceptibilities of C57BL/6 and A/J mouse strains to Streptococcus suis serotype 2 infection. Infect Immun 76(9): 3901-3910.
  67. Richard, K. L., Filali, M., Prefontaine, P. and Rivest, S. (2008). Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci 28(22): 5784-5793.
  68. Soulet, D. and Rivest, S. (2008). Microglia. Curr Biol 18(12): R506-508.
  69. Soulet, D. and Rivest, S. (2008). Bone-marrow-derived microglia: myth or reality? Curr Opin Pharmacol 8(4): 508-518.
  70. Boivin, N., Sergerie, Y., Rivest, S. and Boivin, G. (2008). Pre-treatment with an agonist of toll-like receptor 3 protects BALB/c mice from lethal herpes simplex virus encephalitis. J Infect Dis 198(5): 664-722.
  71. Gosselin, D. and Rivest, S. (2008). MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation. Mol Psychiatry 13(5): 480-497. * Cover page of the journal. May issue. Publication recommended by the Faculty of 1000 Biology (http://www.f1000biology.com)
  72. Kang, J. and Rivest, S. (2007). MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J Cell Biol 179(6): 1219-1230. *Cover story "in this issue" (#179, pp. 1084). Featured on the cover
  73. Turrin, N. P., Plante, M. M., Lessard, M. and Rivest, S. (2007). Irradiation does not compromise or exacerbate the innate immune response in the brains of mice that were transplanted with bone marrow stem cells. Stem Cells 25(12): 3165-3172.
  74. Zhang, J., Shi, X. Q., Echeverry, S., Mogil, J. S., De Koninck, Y. and Rivest, S. (2007). Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci 27(45): 12396-12406.
    *Cover story in "this week in the journal" (#27(45), pp. i)
    *Research Highlights, Nature Clinical Practice Neurology (4: 63-64, 2008)
  75. Boivin, A., Pineau, I., Barrette, B., Filali, M., Vallieres, N., Rivest, S. and Lacroix, S. (2007). Toll-like receptor signaling is critical for Wallerian degeneration and functional recovery after peripheral nerve injury. J Neurosci 27(46): 12565-12576.
  76. Simard, A. R. and Rivest, S. (2007). Neuroprotective effects of resident microglia following acute brain injury. J Comp Neurol 504(6): 716-729.
  77. Dominguez-Punaro, M. C., Segura, M., Plante, M. M., Lacouture, S., Rivest, S. and Gottschalk, M. (2007). Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection. J Immunol 179(3): 1842-1854.
  78. Sergerie, Y., Rivest, S. and Boivin, G. (2007). Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis. J Infect Dis 196(6): 853-860.
  79. Glezer, I., Chernomoretz, A., David, S., Plante, M. M. and Rivest, S. (2007). Genes involved in the balance between neuronal survival and death during inflammation. PLoS One 2(3): e310.
  80. Rice, T., Larsen, J., Rivest, S. and Yong, V. W. (2007). Characterization of the early neuroinflammation after spinal cord injury in mice. J Neuropathol Exp Neurol 66(3): 184-195.
  81. Sergerie, Y., Boivin, G., Gosselin, D. and Rivest, S. (2007). Delayed but not early glucocorticoid treatment protects the host during experimental herpes simplex virus encephalitis in mice. J Infect Dis 195(6): 817-825. *Cover page of the journal, March issue
  82. Letiembre, M., Hao, W., Liu, Y., Walter, S., Mihaljevic, I., Rivest, S., Hartmann, T. and Fassbender, K. (2007). Innate immune receptor expression in normal brain aging. Neuroscience 146(1): 248-254.
  83. Kigerl, K. A., Lai, W., Rivest, S., Hart, R. P., Satoskar, A. R. and Popovich, P. G. (2007). Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 102(1): 37-50.
  84. Simard, A. R., Soulet, D., Gowing, G., Julien, J. P. and Rivest, S. (2006). Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49(4): 489-502.
    *Cover page of the journal. February 16th issue.
    *Highlights, Nature Rev. Neurosci. (April Vol. 7), Lancet Neurology (April Vol. 5), ...
    *Intensively covered by the media; Newspapers (La Presse, Le Soleil, ...), TV (Radio Canada, TVA, WealthTV-USA, ...), Radio (Radio Canada, CBC, ...), Magazines (Pour la Science, Québec/Science, ...).
  85. Glezer, I., Lapointe, A. and Rivest, S. (2006). Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J 20(6): 750-752.
  86. Rivest, S. (2006). Cannabinoids in microglia: a new trick for immune surveillance and neuroprotection. Neuron 49(1): 4-8.
  87. Turrin, N. P. and Rivest, S. (2006). Tumor necrosis factor alpha but not interleukin 1 beta mediates neuroprotection in response to acute nitric oxide excitotoxicity. J Neurosci 26(1): 143-151.
  88. Babcock, A. A., Wirenfeldt, M., Holm, T., Nielsen, H. H., Dissing-Olesen, L., Toft-Hansen, H., Millward, J. M., Landmann, R., Rivest, S., Finsen, B. and Owens, T. (2006). Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26(49): 12826-12837. *Cover story in "this week in the journal" (#26(49), pp. i)
  89. Blais, V., Turrin, N. P. and Rivest, S. (2005). Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. J Neurochem 95(6): 1563-1574.
  90. Letiembre, M., Echchannaoui, H., Ferracin, F., Rivest, S. and Landmann, R. (2005). Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis. J Neuroimmunol 168(1-2): 21-33.
  91. Weaver, A., Goncalves da Silva, A., Nuttall, R. K., Edwards, D. R., Shapiro, S. D., Rivest, S. and Yong, V. W. (2005). An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J 19(12): 1668-1670.
  92. Soucy, G., Boivin, G., Labrie, F. and Rivest, S. (2005). Estradiol is required for a proper immune response to bacterial and viral pathogens in the female brain. J Immunol 174(10): 6391-6398. Publication recommended by the Faculty of 1000 Biology (http://www.f1000biology.com)
  93. Forget, G., Matte, C., Siminovitch, K. A., Rivest, S., Pouliot, P. and Olivier, M. (2005). Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. Eur J Immunol 35(6): 1906-1917.
  94. Simard, A. R. and Rivest, S. (2004). Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J 18(9): 998-1000.
    * Cover page of the journal, June issue.
  95. Blais, V. and Rivest, S. (2004). Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain. J Immunol 172(11): 7043-7052.
  96. Turrin, N. P. and Rivest, S. (2004). Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol Dis 16(2): 321-334.
  97. Soulet, D., Gagnon, B., Rivest, S., Audette, M. and Poulin, R. (2004). A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism. J Biol Chem 279(47): 49355-49366.
  98. Nguyen, M. D., D'Aigle, T., Gowing, G., Julien, J. P. and Rivest, S. (2004). Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci 24(6): 1340-1349.
  99. Fassbender, K., Walter, S., Kuhl, S., Landmann, R., Ishii, K., Bertsch, T., Stalder, A. K., Muehlhauser, F., Liu, Y., Ulmer, A. J., Rivest, S., Lentschat, A., Gulbins, E., Jucker, M., Staufenbiel, M., Brechtel, K., Walter, J., Multhaup, G., Penke, B., Adachi, Y., Hartmann, T. and Beyreuther, K. (2004). The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J 18(1): 203-205.
  100. Soulet, D. and Rivest, S. (2003). Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system. J Cell Biol 162(2): 257-268.
    *Cover story "in this issue" (#162, pp. 166)
    *Highlights, Nature Rev. Neurosci., vol. 4(9), pp 697
  101. Glezer, I., Zekki, H., Scavone, C. and Rivest, S. (2003). Modulation of the innate immune response by NMDA receptors has neuropathological consequences. J Neurosci 23(35): 11094-11103.
  102. Nadeau, S. and Rivest, S. (2003). Glucocorticoids play a fundamental role in protecting the brain during innate immune response. J Neurosci 23(13): 5536-5544.
    *Cover story in "this week in the journal" (#23(13), pp. i)
  103. Babcock, A. A., Kuziel, W. A., Rivest, S. and Owens, T. (2003). Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci 23(21): 7922-7930. *Cover story in "this week in the journal" (#23(21), pp. i)
  104. Wells, J. E., Rice, T. K., Nuttall, R. K., Edwards, D. R., Zekki, H., Rivest, S. and Yong, V. W. (2003). An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice. J Neurosci 23(31): 10107-10115.
  105. Laflamme, N., Echchannaoui, H., Landmann, R. and Rivest, S. (2003). Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria. Eur J Immunol 33(4): 1127-1138.
  106. Duguay, Y., Lapointe, A., Lavallee, B., Hum, D. W. and Rivest, S. (2003). Cloning of murine TReP-132, a novel transcription factor expressed in brain regions involved in behavioral and psychiatric disorders. Mol Psychiatry 8(1): 39-49. *Cover page of the journal
  107. Duguay, Y., Lapointe, A., Lavallee, B., HUM, D. W. and Rivest, S. (2002). Cortical and hippocampal expression of the gene encoding a new transcriptional regulating protein. Mol Psychiatr 7(10):1036.
  108. Nadeau, S. and Rivest, S. (2002). Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14. J Immunol 169(6): 3370-3381.
  109. Nguyen, M. D., Julien, J. P. and Rivest, S. (2002). Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 3(3): 216-227.
    *One of the ten discoveries of the year by the magazine Québec/Science, February 2003
  110. Blais, V., Zhang, J. and Rivest, S. (2002). In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain. Endocrinology 143(12): 4820-4827.
  111. Rivest, S. (2002). Does circulating leptin have the ability to cross the blood-brain barrier and target neurons directly? Endocrinology 143(9): 3211-3213.
  112. Zekki, H., Feinstein, D. L. and Rivest, S. (2002). The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol 12(3): 308-319.
  113. Soulet, D. and Rivest, S. (2002). How to make microarray, serial analysis of gene expression, and proteomic relevant to day-to-day endocrine problems and physiological systems? Endocrinology 143(6): 1995-2001.
  114. Boivin, G., Coulombe, Z. and Rivest, S. (2002). Intranasal herpes simplex virus type 2 inoculation causes a profound thymidine kinase dependent cerebral inflammatory response in the mouse hindbrain. Eur J Neurosci 16(1): 29-43.
  115. Rivest, S. (2002). Are glucocorticoids good or bad for brain development and plasticity? Endocrinology 143(4): 1157-1158.
  116. Sebastiani, G., Blais, V., Sancho, V., Vogel, S. N., Stevenson, M. M., Gros, P., Lapointe, J. M., Rivest, S. and Malo, D. (2002). Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strains. Infect Immun 70(4): 1997-2009.
  117. Nguyen, M. D., Julien, J. P. and Rivest, S. (2001). Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1beta in neurodegeneration. Ann Neurol 50(5): 630-639.
  118. Laflamme, N., Soucy, G. and Rivest, S. (2001). Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J Neurochem 79(3): 648-657.
  119. Nadeau, S. and Rivest, S. (2001). The complement system is an integrated part of the natural innate immune response in the brain. FASEB J 15(8): 1410-1412. *Cover page of the journal
  120. Blais, V. and Rivest, S. (2001). Inhibitory action of nitric oxide on circulating tumor necrosis factor-induced NF-kappaB activity and COX-2 transcription in the endothelium of the brain capillaries. J Neuropathol Exp Neurol 60(9): 893-905.
  121. Laflamme, N. and Rivest, S. (2001). Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J 15(1): 155-163.
  122. Thibeault, I., Laflamme, N. and Rivest, S. (2001). Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. J Comp Neurol 434(4): 461-477.
  123. Zhang, J. and Rivest, S. (2001). Anti-inflammatory effects of prostaglandin E2 in the central nervous system in response to brain injury and circulating lipopolysaccharide. J Neurochem 76(3): 855-864.
  124. Forget, G., Siminovitch, K. A., Brochu, S., Rivest, S., Radzioch, D. and Olivier, M. (2001). Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis. Eur J Immunol 31(11): 3185-3196.
  125. Nadeau, S. and Rivest, S. (2000). Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia. J Neurosci 20(9): 3456-3468.
  126. Herx, L. M., Rivest, S. and Yong, V. W. (2000). Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor. J Immunol 165(4): 2232-2239.
  127. Lebel, E., Vallieres, L. and Rivest, S. (2000). Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges. Endocrinology 141(10): 3749-3763.
  128. Zhang, J. and Rivest, S. (2000). A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta. J Neurochem 74(5): 2134-2145.
  129. Vallieres L. and Rivest, S. (2000). L'interleukine-6 dans le système nerveux central. Médecine/Sciences 16: 936-944.
  130. Laflamme, N., Lacroix, S. and Rivest, S. (1999). An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. J Neurosci 19(24): 10923-10930.
  131. Zhang, J. and Rivest, S. (1999). Distribution, regulation and colocalization of the genes encoding the EP2- and EP4-PGE2 receptors in the rat brain and neuronal responses to systemic inflammation. Eur J Neurosci 11(8): 2651-2668.
  132. Nadeau, S. and Rivest, S. (1999). Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier. Neuroscience 93(4): 1449-1464.
  133. Vallieres, L. and Rivest, S. (1999). Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia. Endocrinology 140(9): 3890-3903.
  134. Laflamme, N. and Rivest, S. (1999). Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain. J Neurochem 73(1): 309-321.
  135. Nadeau, S. and Rivest, S. (1999). Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge. J Neuropathol Exp Neurol 58(1): 61-77.
  136. Laflamme, N., Feuvrier, E., Richard, D. and Rivest, S. (1999). Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats. Neuroscience 88(1): 223-240.
  137. Brochu, S., Olivier, M. and Rivest, S. (1999). Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei. J Neurosci Res 57(6): 801-816.
  138. Sakic, B., Laflamme, N., Crnic, L. S., Szechtman, H., Denburg, J. A. and Rivest, S. (1999). Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction. J Neuroimmunol 96(1): 80-91.
  139. Lacroix, S., Feinstein, D. and Rivest, S. (1998). The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations. Brain Pathol 8(4): 625-640.
  140. Lacroix, S. and Rivest, S. (1998). Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain. J Neurochem 70(2): 452-466.
  141. Laflamme, N., Nappi, R. E., Drolet, G., Labrie, C. and Rivest, S. (1998). Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J Neurobiol 36(3): 357-378.
  142. Torres, G., Horowitz, J. M., Laflamme, N. and Rivest, S. (1998). Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain. Neuroscience 87(2): 463-477.
  143. Bonaz, B. and Rivest, S. (1998). Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain. Am J Physiol 275(5 Pt 2): R1438-1449.
  144. Mansi, J. A., Rivest, S. and Drolet, G. (1998). Effect of immobilization stress on transcriptional activity of inducible immediate-early genes, corticotropin-releasing factor, its type 1 receptor, and enkephalin in the hypothalamus of borderline hypertensive rats. J Neurochem 70(4): 1556-1566.
  145. Lacroix, S. and Rivest, S. (1997). Functional circuitry in the brain of immune-challenged rats: partial involvement of prostaglandins. J Comp Neurol 387(2): 307-324.
  146. Vallieres, L., Lacroix, S. and Rivest, S. (1997). Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration. Eur J Neurosci 9(7): 1461-1472.
  147. Vallieres, L. and Rivest, S. (1997). Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta. J Neurochem 69(4): 1668-1683.
  148. Nappi, R. E. and Rivest, S. (1997). Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level. Endocrinology 138(4): 1374-1384.
  149. Van Vugt, D. A., Piercy, J., Farley, A. E., Reid, R. L. and Rivest, S. (1997). Luteinizing hormone secretion and corticotropin-releasing factor gene expression in the paraventricular nucleus of rhesus monkeys following cortisol synthesis inhibition. Endocrinology 138(6): 2249-2258.
  150. Nappi, R. E., Bonneau, M. J. and Rivest, S. (1997). Influence of the estrous cycle on c-fos and CRH gene transcription in the brain of endotoxin-challenged female rats. Neuroendocrinology 65(1): 29-46.
  151. Laflamme, N., Barden, N. and Rivest, S. (1997). Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid. J Mol Neurosci 8(3): 165-179.
  152. Naimi, N., Rivest, S., Racotta, I. and Richard, D. (1997). Neuronal activation of the hypothalamic magnocellular system in response to oropharyngeal stimuli in the rat. J Neuroendocrinol 9(5): 329-340.
  153. Lacroix, S., Vallieres, L. and Rivest, S. (1996). C-fos mRNA pattern and corticotropin-releasing factor neuronal activity throughout the brain of rats injected centrally with a prostaglandin of E2 type. J Neuroimmunol 70(2): 163-179.
  154. Lacroix, S. and Rivest, S. (1996). Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on the transcription of a specific CRF receptor subtype in the rat brain. J Chem Neuroanat 10(1): 53-71.
  155. Laflamme, N., Bovetto, S., Richard, D. and Rivest, S. (1996). Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus. Br J Pharmacol 117(6): 1021-1034.
  156. Richard, D., Rivest, R., Naimi, N., Timofeeva, E. and Rivest, S. (1996). Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats. Endocrinology 137(11): 4786-4795.
  157. Mansi, J. A., Rivest, S. and Drolet, G. (1996). Regulation of corticotropin-releasing factor type 1 (CRF1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF. Endocrinology 137(11): 4619-4629.
  158. Rivest, S., Laflamme, N. and Nappi, R. E. (1995). Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus. J Neurosci 15(4): 2680-2695.
  159. Rivest, S. and Laflamme, N. (1995). Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats. J Neuroendocrinol 7(7): 501-525.
  160. Nappi, R. E. and Rivest, S. (1995). Ovulatory cycle influences the stimulatory effect of stress on the expression of corticotropin-releasing factor receptor messenger ribonucleic acid in the paraventricular nucleus of the female rat hypothalamus. Endocrinology 136(9): 4073-4083.
  161. Rivest, S. (1995). Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat. Int J Dev Neurosci 13(3-4): 135-146.
    *Cover page of the journal
  162. Rivest, S. and Rivier, C. (1995). The role of corticotropin-releasing factor and interleukin-1 in the regulation of neurons controlling reproductive functions. Endocr Rev 16(2): 177-199. (pair-reviewed) *Cover page of the journal
  163. Nappi, R. E. and Rivest, S. (1995). Stress-induced genetic expression of a selective corticotropin-releasing factor-receptor subtype within the rat ovaries: an effect dependent on the ovulatory cycle. Biol Reprod 53(6): 1417-1428.
  164. Nappi, R. E. and Rivest, S. (1995). Corticotropin-releasing factor (CRF) and stress-related reproductive failure: the brain as a state of the art or the ovary as a novel clue? J Endocrinol Invest 18(11): 872-880.
  165. Rivest, S. and Lacroix, S. (1995). [Influence of cytokines on neuroendocrine functions during immune response. Méchanisms involved and neuronal pathways]. Ann Endocrinol (Paris) 56(3): 159-167.
  166. Rivest, S. and Rivier, C. (1994). Stress and interleukin-1 beta-induced activation of c-fos, NGFI-B and CRF gene expression in the hypothalamic PVN: comparison between Sprague-Dawley, Fisher-344 and Lewis rats. J Neuroendocrinol 6(1): 101-117.
  167. Stenzel-Poore, M. P., Heinrichs, S. C., Rivest, S., Koob, G. F. and Vale, W. W. (1994). Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. J Neurosci 14(5 Pt 1): 2579-2584.
  168. Rivest, S. and Rivier, C. (1994). Lesions of hypothalamic PVN partially attenuate stimulatory action of alcohol on ACTH secretion in rats. Am J Physiol 266(2 Pt 2): R553-558.
  169. Rivest, S., Lee, S., Attardi, B. and Rivier, C. (1993). The chronic intracerebroventricular infusion of interleukin-1 beta alters the activity of the hypothalamic-pituitary-gonadal axis of cycling rats. I. Effect on LHRH and gonadotropin biosynthesis and secretion. Endocrinology 133(6): 2424-2430.
  170. Parkes, D., Rivest, S., Lee, S., Rivier, C. and Vale, W. (1993). Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus. Mol Endocrinol 7(10): 1357-1367.
  171. Rivest, S. and Rivier, C. (1993). Interleukin-1 beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat. Brain Res 613(1): 132-142.
  172. Rivest, S. and Rivier, C. (1993). Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats. J Neuroendocrinol 5(4): 445-450.
  173. Rivest, S., Plotsky, P. M. and Rivier, C. (1993). CRF alters the infundibular LHRH secretory system from the medial preoptic area of female rats: possible involvement of opioid receptors. Neuroendocrinology 57(2): 236-246.
  174. Rivest, S., Torres, G. and Rivier, C. (1992). Differential effects of central and peripheral injection of interleukin-1 beta on brain c-fos expression and neuroendocrine functions. Brain Res 587(1): 13-23.
  175. Richard, D., Rivest, S. and Rivier, C. (1992). The 5-hydroxytryptamine agonist fenfluramine increases Fos-like immunoreactivity in the brain. Brain Res 594(1): 131-137.
  176. Rivier, C., Rivest, S. and Vale, W. (1992). Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms. Alcohol Clin Exp Res 16(5): 935-941.
  177. Richard, D., Labrie, A. and Rivest, S. (1992). Tissue specificity of SNS response to exercise in mice exposed to low temperatures. Am J Physiol 262(5 Pt 2): R921-925.
  178. Ouerghi, D., Rivest, S. and Richard, D. (1992). Adrenalectomy attenuates the effect of chemical castration on energy balance in rats. J Nutr 122(2): 369-373.
  179. Rivier, C. and Rivest, S. (1991). Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms. Biol Reprod 45(4): 523-532.
  180. Rivest, S. and Rivier, C. (1991). Influence of the paraventricular nucleus of the hypothalamus in the alteration of neuroendocrine functions induced by intermittent footshock or interleukin. Endocrinology 129(4): 2049-2057.
  181. Itey, P., Rivest, S. and Richard, D. (1991). Effects of exercise on energy balance in meal-fed mice. Physiol Behav 49(2): 271-276.
  182. Richard, D., DeKoninck, P., Lemay, A. and Rivest, S. (1991). Reversible increase in energy deposition following castration induced by a gonadotropin releasing hormone agonist. Int J Obes 15(2): 155-161.
  183. Rivest, S. and Richard, D. (1990). Involvement of corticotropin-releasing factor in the anorexia induced by exercise. Brain Res Bull 25(1): 169-172.
  184. Rivest, S. and Richard, D. (1990). Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats. Am J Physiol 259(3 Pt 2): R579-584.
  185. Rivest, S., Deshaies, Y. and Richard, D. (1989). Effects of corticotropin-releasing factor on energy balance in rats are sex dependent. Am J Physiol 257(6 Pt 2): R1417-1422.
  186. Rivest, S., Landry, J. and Richard, D. (1989). Effect of exercise training on energy balance of orchidectomized rats. Am J Physiol 257(3 Pt 2): R550-555.
  187. Richard, D. and Rivest, S. (1989). The role of exercise in thermogenesis and energy balance. Can J Physiol Pharmacol 67(4): 402-409.

Invited reviews and book chapters (published or in press)

  1. Rivest, S. (2010). Interactions between the immune and neuroendocrine systems. Prog Brain Res 181: 43-53.
  2. Rivest, S. (2009). Immune system-neuroendocrine interactions. In: Squire, L. R. (ed). The Encyclopedia of Neuroscience 5: 109-115. Oxford Academic Press.
  3. Boissonneault, V. and Rivest, S. (2009). The hematopoietic cytokine M-CSF as a cure for Alzheimer's disease. Médecine/Sciences 25(8-9): 666-668.
  4. Glezer, I., Simard, A. R. and Rivest, S. (2007). Neuroprotective role of the innate immune system by microglia. Neuroscience 147(4): 867-883.
  5. Gosselin, D. and Rivest, S. (2007). Role of IL-1 and TNF in the brain: twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system. Brain Behav Immun 21(3): 281-289.
  6. Turrin, N. P. and Rivest, S. (2006). Molecular and cellular immune mediators of neuroprotection. Mol Neurobiol 34(3): 221-242.
  7. Simard, A. R. and Rivest, S. (2006). [Bone marrow stem cells to the rescue of Alzheimer's disease]. Med Sci (Paris) 22(10): 822-824.
  8. Simard, A. R. and Rivest, S. (2006). Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease. Mol Psychiatry 11(4): 327-335.
    * Cover page of the journal. April issue.
    * Feature review of the month.
  9. Soulet, D. and Rivest, S. (2006). New role of polyamines in the control of innate immune response in mouse CNS. In: Wang, J. Y. and Casero, R. A. (eds). Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research. Humana Press.
  10. Simard, A. R. and Rivest, S. (2005). Do pathogen exposure and innate immunity cause brain diseases? Neurol Res 27(7): 717-725.
  11. Turrin, N. P. and Rivest, S. (2004). Unraveling the molecular details involved in the intimate link between the immune and neuroendocrine systems. Exp Biol Med (Maywood) 229(10): 996-1006.
  12. Simard, A. R. and Rivest, S. (2004). Role of inflammation in the neurobiology of stem cells. Neuroreport 15(15): 2305-2310.
  13. Glezer, I. and Rivest, S. (2004). Glucocorticoids: protectors of the brain during innate immune responses. Neuroscientist 10(6): 538-552.
  14. Zhang, J. and Rivest, S. (2004). Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway. In: Curtis-Prior, P. (Ed). The Eicosanoids. John Wiley & Sons: 463-472.
  15. Blais, V. and Rivest, S. (2003). Rôle de la réponse immunitaire innée dans le cerveau. Médecine/Sciences 19: 981-987.
  16. Zhang, J. and Rivest, S. (2003). Is survival possible without arachidonate metabolites in the brain during systemic infection? News Physiol Sci 18:137-142. * Cover page of the journal.
  17. Rivest, S. (2003). Molecular insights on the cerebral innate immune system. Brain Behav Immun 17(1): 13-19. * Cover page of the journal.
  18. Rivest, S. (2003). Immune function and regulation of the ANS: a molecular point of view. In: Bolis, C. L., Licinio, J. and Stefano, S. (Eds). Handbook of Autonomic Nervous System in Health and Disease. Marcel Dekker, New York, pp, 55-134.
  19. Rivest, S. (2001). How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrino 26(8): 761-788.
  20. Rivest, S., Nadeau, S., Lacroix, S. and Laflamme, N. (2001). Proinflammatory signal transduction pathways in the CNS during systemic immune response. In: Berczi, I. and Gorczynski, R. M. (Eds). Neuroimmune biology: new foundation of biology. Elsevier, Amsterdam 1: 163-173.
  21. Drolet, G. and Rivest, S. (2001). Corticotropin-releasing factor and its receptors; an evaluation at the transcription level in vivo. Peptides 22(5): 761-767.
  22. Rivest, S., Lacroix, S., Vallieres, L., Nadeau, S., Zhang, J. and Laflamme, N. (2000). How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. P Soc Exp Biol Med 223: 22-38.
  23. Rivest, S. (1999). What is the cellular source of prostaglandins in the brain in response to systemic inflammation? facts and controversies. Mol Psychiatr 4(6): 501-507.
  24. Rivest, S. (1999). Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation. Mol Psychiatry 4(6): 500.
  25. Rivest, S. (1999). Immune response and brain gene expression in relation to stress. In: Bolis, C. L. and Licinio, J. L. (Eds). Stress and Adaptation: From Selye's concept to application of modern formulations. World Health Organization, Geneva, Switzerland: 109-130.
  26. Rivest, S. and Cusan, L. (1999). Luteinizing hormone-releasing hormone (LHRH) neuronal system: from basic to clinical. In: Watson, S. J. (ed). The Fourth Generation of Progress of the American College of Neuropsychopharmacology (ACNP). Lippincott-Raven-Williams & Wilkins Publishers, Philadelphia, PA, 58: 121.
  27. Nappi, R. E. and Rivest, S. (1997). Interleukin-1 and luteinizing hormone-releasing hormone system: a powerful interaction within the brain still lacking of anatomical and physiological links. In: Coutifaris, C. and Mastroianni, L. (Eds). New horizons in reproductive medicine. The Parthenon Publishing Group limited, London, England, pp, 191-197.
  28. Nappi, R. E., Costa, A., Poma, A., Farina, C., Zara, C. and Rivest, S. (1997). Aging female brain: is there a change of adaptive stress? Aging (Milano) 9(4 Suppl): 64-65.
  29. Nappi, R. E. and Rivest, S. (1995). Cytokines, immune factors and reproductive axis: A view from the brain. In: Monduzzi Editor S.p.A. Pathophysiological basis for the treatment of endocrine dysfunctions in women. Bologna, Italy, pp, 361-374.
  30. Rivier, C. and Rivest, S. (1993). Central mechanisms and sites of action involved in the inhibitory effects of CRF and cytokines on LHRH neuronal activity. In: Taché, Y. and Rivier, C. (Eds). Corticotropin-releasing factor and Cytokines: Role in the stress response, Hans Selye symposium on neuroendocrinology and stress. Ann NY Acad Sci 697: 117-141, 1993.
  31. Rivier, C. and Rivest, S. (1993). Mechanisms mediating the effects of cytokines on neuroendocrine functions in the rat. In: Widdows, K. (Ed). Corticotropin-Releasing Factor. Ciba Foundation Symposium no 172 (London), John Wiley and Sons Ltd, Chichester, England, pp, 204-225.
  32. Rivier, C., Rivier, J., Rivest, S. and Vale, W. (1992). Peptides and proteins act as bridges between the immune and the endocrine systems. In: Smith, J. A. and Rivier, J. E. (Eds). Peptides: Chemistry and Biology. ESCOM Science Publishers B.V., The Netherlands, pp, 829-831.
  33. Rivest, S. and Richard, D. (1990). Mécanismes de la régulation neuroendocrinienne du bilan d'énergie chez le rat entraîné à l'exercice prolongé. Physiologie Canada 21(3): 126-128.
  34. Rivest, S. (2008). Inflammation and immune cell entry to the central nervous system. In : Kastin, A. and Pan, W. (eds). The Blood-Brain Barrier: Understanding the regulatory gatekeeper between brain and body. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0381653-Rivest)
  35. Rivest, S. Molecular Insights on the Innate Immune System in the CNS. New York Academy of Sciences, NY.
Protocols by Serge Rivest
  1. Fluoro-Jade B Staining for Neuronal Cell Death
  2. Isolation and Purification of Murine Microglial Cells for Flow Cytometry