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Nathalie Laflamme

Education

M.S. in Physiology-Endocrinology, Faculty of medicine, Université Laval, CHU de Québec

Current position

Research professional , CHUL Research Center, Québec (1993-present)

Publications

  1. Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M. M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M. È. and Rivest, S. (2015). Inefficient clearance of myelin debris by microglia impairs remyelinating processes. J Exp Med 212(4): 481-495.
  2. Naert, G., Laflamme, N. and Rivest, S. (2009). Toll-like receptor 2-independent and MyD88-dependent gene expression in the mouse brain. J Innate Immun 1(5): 480-493.
  3. Laflamme, N., Echchannaoui, H., Landmann, R. and Rivest, S. (2003). Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria. Eur J Immunol 33(4): 1127-1138.
  4. Laflamme, N., Soucy, G. and Rivest, S. (2001). Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J Neurochem 79(3): 648-657.
  5. Thibeault, I., Laflamme, N. and Rivest, S. (2001). Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines. J Comp Neurol 434(4): 461-477.
  6. Laflamme, N. and Rivest, S. (2001). Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. FASEB J 15(1): 155-163.
  7. Rivest, S., Lacroix, S., Vallieres, L., Nadeau, S., Zhang, J. and Laflamme, N. (2000). How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 223(1): 22-38.
  8. Laflamme, N., Lacroix, S. and Rivest, S. (1999). An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. J Neurosci 19(24): 10923-10930.
  9. Laflamme, N. and Rivest, S. (1999). Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain. J Neurochem 73(1): 309-321.
  10. Sakić, B., Laflamme, N., Crnic, L. S., Szechtman, H., Denburg, J. A. and Rivest, S. (1999). Reduced corticotropin-releasing factor and enhanced vasopressin gene expression in brains of mice with autoimmunity-induced behavioral dysfunction. J Neuroimmunol 96(1): 80-91.
  11. Laflamme, N., Feuvrier, E., Richard, D. and Rivest, S. (1999). Involvement of serotonergic pathways in mediating the neuronal activity and genetic transcription of neuroendocrine corticotropin-releasing factor in the brain of systemically endotoxin-challenged rats. Neuroscience 88(1): 223-240.
  12. Torres, G., Horowitz, J. M., Laflamme, N. and Rivest, S. (1998). Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain. Neuroscience 87(2): 463-477.
  13. Laflamme, N., Nappi, R. E., Drolet, G., Labrie, C. and Rivest, S. (1998). Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype. J Neurobiol 36(3): 357-378.
  14. Laflamme, N., Barden, N. and Rivest, S. (1997). Corticotropin-releasing factor and glucocorticoid receptor (GR) gene expression in the paraventricular nucleus of immune-challenged transgenic mice expressing type II GR antisense ribonucleic acid. J Mol Neurosci 8(3): 165-179.
  15. Laflamme, N., Bovetto, S., Richard, D. and Rivest, S. (1996). Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus. Br J Pharmacol 117(6): 1021-1034.
  16. Laflamme, N., Leblanc, J. F., Mailloux, J., Faure, N., Labrie, F. and Simard, J. (1996). Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients. J Clin Endocrinol Metab 81(1): 264-268.
  17. Mébarki, F., Sanchez, R., Rhéaume, E., Laflamme, N., Simard, J., Forest, M. G., Bey-Omar, F., David, M., Labrie, F. and Morel, Y. (1995). Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3 beta-hydroxysteroid dehydrogenase gene. J Clin Endocrinol Metab 80(7): 2127-2134.
  18. Rivest, S. and Laflamme, N. (1995). Neuronal activity and neuropeptide gene transcription in the brains of immune-challenged rats. J Neuroendocrinol 7(7): 501-525.
  19. Rivest, S., Laflamme, N. and Nappi, R. E. (1995). Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus. J Neurosci 15(4): 2680-2695.
  20. Sanchez, R., Mébarki, F., Rhéaume, E., Laflamme, N., Forest, M. G., Bey-Omard, F., David, M., Morel, Y., Labrie, F. and Simard, J. (1994). Functional characterization of the novel L108W and P186L mutations detected in the type II 3 beta-hydroxysteroid dehydrogenase gene of a male pseudohermaphrodite with congenital adrenal hyperplasia. Hum Mol Genet 3(9): 1639-1645.
  21. Sanchez, R., Rhéaume, E., Laflamme, N., Rosenfield, R. L., Labrie, F. and Simard, J. (1994). Detection and functional characterization of the novel missense mutation Y254D in type II 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) gene of a female patient with nonsalt-losing 3 beta HSD deficiency. J Clin Endocrinol Metab 78(3): 561-567.
  22. Simard, J., Rhéaume, E., Sanchez, R., Laflamme, N., de Launoit, Y., Luu-The, V., van Seters, A. P., Gordon, R. D., Bettendorf, M., Heinrich, U. and et al. (1993). Molecular basis of congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency. Mol Endocrinol 7(5): 716-728.
Protocols by Nathalie Laflamme
  1. Fluoro-Jade B Staining for Neuronal Cell Death