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Francisca Mulero

Education

M.D. Doctor in Medicine and Surgery, University of Alicante, 1992
Speciality (MIR) in Nuclear Medicine, Hospital Virgen de la Arrixaca, Murcia, 1997

Current position

Head, Molecular Imaging Unit at the CNIO (Centro Nacional de Investigaciones oncológicas) (2007-now)

Publications (since 2005)

  1. Portal-Núñez, S., Ardura, J. A., Lozano, D., Bolivar, O. H., López-Herradón, A., Gutiérrez-Rojas, I., Proctor, A., van der Eerden, B., Schreuders-Koedam, M., van Leeuwen, J., Alcaraz, M. J., Mulero, F., de la Fuente, M. and Esbrit, P. (2015). Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice. J Gerontol A Biol Sci Med Sci.
  2. Cioffi, M., Vallespinos-Serrano, M., Trabulo, S. M., Fernandez-Marcos, P. J., Firment, A. N., Vazquez, B. N., Vieira, C. R., Mulero, F., Camara, J. A., Cronin, U. P., Perez, M., Soriano, J., B, G. G., Castells-Garcia, A., Haage, V., Raj, D., Megias, D., Hahn, S., Serrano, L., Moon, A., Aicher, A. and Heeschen, C. (2015). MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3. Cell Rep 12(10): 1594-1605.
  3. Muñoz-Mediavilla, C., Cámara, J. A., Salazar, S., Segui, B., Sanguino, D., Mulero, F., de la Cueva, E. and Blanco, I. (2015). Evaluation of the foetal time to death in mice after application of direct and indirect euthanasia methods. Lab Anim.
  4. Povedano, J. M., Martinez, P., Flores, J. M., Mulero, F. and Blasco, M. A. (2015). Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction. Cell Rep 12(2): 286-299.
  5. García-Beccaria, M., Martínez, P., Méndez-Pertuz, M., Martínez, S., Blanco-Aparicio, C., Cañamero, M., Mulero, F., Ambrogio, C., Flores, J. M., Megias, D., Barbacid, M., Pastor, J. and Blasco, M. A. (2015). Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage. EMBO Mol Med 7(7): 930-949.
  6. Bär, C., Bernardes de Jesus, B., Serrano, R., Tejera, A., Ayuso, E., Jimenez, V., Formentini, I., Bobadilla, M., Mizrahi, J., de Martino, A., Gomez, G., Pisano, D., Mulero, F., Wollert, K. C., Bosch, F. and Blasco, M. A. (2014). Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction. Nat Commun 5: 5863.
  7. Hernández-Porras, I., Fabbiano, S., Schuhmacher, A. J., Aicher, A., Cañamero, M., Cámara, J. A., Cussó, L., Desco, M., Heeschen, C., Mulero, F., Bustelo, X. R., Guerra, C. and Barbacid, M. (2014). K-RasV14I recapitulates Noonan syndrome in mice. Proc Natl Acad Sci U S A 111(46): 16395-16400. 
  8. Ambrogio, C., Carmona, F. J., Vidal, A., Falcone, M., Nieto, P., Romero, O. A., Puertas, S., Vizoso, M., Nadal, E., Poggio, T., Sanchez-Cespedes, M., Esteller, M., Mulero, F., Voena, C., Chiarle, R., Barbacid, M., Santamaria, D. and Villanueva, A. (2014). Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. Cancer Res 74(21): 5978-5988.
  9. Cámara, J. A., Andrés, E., Sánchez, S. and Mulero, F. (2014). Imagen molecular PET-TC en investigación preclínica oncológica. Radioproteccion 79:44-49.
  10. Lozano, D., Sánchez-Salcedo, S., Portal-Núñez, S., Vila, M., López-Herradón, A., Ardura, J. A., Mulero, F., Gómez-Barrena, E., Vallet-Regí, M. and Esbrit, P. (2014). Parathyroid hormone-related protein (107-111) improves the bone regeneration potential of gelatin-glutaraldehyde biopolymer-coated hydroxyapatite. Acta Biomater 10(7): 3307-3316.
  11. Rubio, R., Abarrategi, A., Garcia-Castro, J., Martinez-Cruzado, L., Suarez, C., Tornin, J., Santos, L., Astudillo, A., Colmenero, I., Mulero, F., Rosu-Myles, M., Menendez, P. and Rodriguez, R. (2014). Bone environment is essential for osteosarcoma development from transformed mesenchymal stem cells. Stem Cells 32(5): 1136-1148.
  12. Abarrategi, A., Perez-Tavarez, R., Rodriguez-Milla, M. A., Cubillo, I., Mulero, F., Alfranca, A., Lopez-Lacomba, J. L. and Garcia-Castro, J. (2013). In vivo ectopic implantation model to assess human mesenchymal progenitor cell potential. Stem Cell Rev 9(6): 833-846.
  13. Portal-Núñez, S., Manassra, R., Lozano, D., Acitores, A., Mulero, F., Villanueva-Peñacarrillo, M. L., De la Fuente, M. and Esbrit, P. (2013). Characterization of skeletal alterations in a model of prematurely aging mice. Age (Dordr) 35(2): 383-393.
  14. Maraver, A., Fernandez-Marcos, P. J., Herranz, D., Cañamero, M., Muñoz-Martin, M., Gómez-López, G., Mulero, F., Megías, D., Sanchez-Carbayo, M., Shen, J., Sanchez-Cespedes, M., Palomero, T., Ferrando, A. and Serrano, M. (2012). Therapeutic effect of gamma-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. Cancer Cell 22(2): 222-234.
  15. Martínez González, S., Hernández, A. I., Varela, C., Lorenzo, M., Ramos-Lima, F., Cendón, E., Cebrián, D., Aguirre, E., Gomez-Casero, E., Albarrán, M. I., Alfonso, P., García-Serelde, B., Mateos, G., Oyarzabal, J., Rabal, O., Mulero, F., Gonzalez-Granda, T., Link, W., Fominaya, J., Barbacid, M., Bischoff, J. R., Pizcueta, P., Blanco-Aparicio, C. and Pastor, J. (2012). Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR. Bioorg Med Chem Lett 22(16): 5208-5214.
  16. Martínez González, S., Hernández, A. I., Varela, C., Rodríguez-Arístegui, S., Lorenzo, M., Rodríguez, A., Rivero, V., Martín, J. I., Saluste, C. G., Ramos-Lima, F., Cendón, E., Cebrián, D., Aguirre, E., Gomez-Casero, E., Albarrán, M., Alfonso, P., García-Serelde, B., Oyarzabal, J., Rabal, O., Mulero, F., Gonzalez-Granda, T., Link, W., Fominaya, J., Barbacid, M., Bischoff, J. R., Pizcueta, P. and Pastor, J. (2012). Identification of ETP-46321, a potent and orally bioavailable PI3K alpha, delta inhibitor. Bioorg Med Chem Lett 22(10): 3460-3466.
  17. Abarrategi, A., Moreno-Vicente, C., Martínez-Vázquez, F. J., Civantos, A., Ramos, V., Sanz-Casado, J. V., Martínez-Corriá, R., Perera, F. H., Mulero, F., Miranda, P. and López-Lacomba, J. L. (2012). Biological properties of solid free form designed ceramic scaffolds with BMP-2: in vitro and in vivo evaluation. PLoS One 7(3): e34117.
  18. Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martínez, S., Romanos, E., Mar Gonzalez-Barroso, M., Rial, E., Valverde, A. M., Bischoff, J. R. and Serrano, M. (2012). Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab 15(3): 382-394.
  19. Pacheco, M., Valencia, M., Caparrós-Martín, J. A., Mulero, F., Goodship, J. A. and Ruiz-Perez, V. L. (2012). Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base. Bone 50(1): 28-41.
  20. Mulero, F., Donate, L. E. and Serrano, M. (2011). Imaging Cancer in Mice by PET, CT, and Combined PET-CT. Curr Protoc Mouse Biol 1(1): 85-103.
  21. Urosevic, J., Sauzeau, V., Soto-Montenegro, M. L., Reig, S., Desco, M., Wright, E. M., Canamero, M., Mulero, F., Ortega, S., Bustelo, X. R. and Barbacid, M. (2011). Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proc Natl Acad Sci U S A 108(12): 5015-5020.
  22. Saif, J., Schwarz, T. M., Chau, D. Y., Henstock, J., Sami, P., Leicht, S. F., Hermann, P. C., Alcala, S., Mulero, F., Shakesheff, K. M., Heeschen, C. and Aicher, A. (2010). Combination of injectable multiple growth factor-releasing scaffolds and cell therapy as an advanced modality to enhance tissue neovascularization. Arterioscler Thromb Vasc Biol 30(10): 1897-1904.
  23. Puyol, M., Martin, A., Dubus, P., Mulero, F., Pizcueta, P., Khan, G., Guerra, C., Santamaria, D. and Barbacid, M. (2010). A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18(1): 63-73.
  24. Herranz, D., Muñoz-Martín, M., Cañamero, M., Mulero, F., Martínez-Pastor, B., Fernández-Capetillo, O. and Serrano, M. (2010). Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 1: 3.
  25. McNees, C. J., Tejera, A. M., Martínez, P., Murga, M., Mulero, F., Fernandez-Capetillo, O. and Blasco, M. A. (2010). ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. J Cell Biol 188(5): 639-652.
  26. Perez, J. and Mulero, F. (2010). Imagen Molecular en Investigación Biomédica. Unidad de Imagen Molecular del Centro Nacional de Investigaciones Oncológicas. Radioprotección 17: 26-35.
  27. Tormo, D., Checińska, A., Alonso-Curbelo, D., Pérez-Guijarro, E., Cañón, E., Riveiro-Falkenbach, E., Calvo, T. G., Larribere, L., Megías, D., Mulero, F., Piris, M. A., Dash, R., Barral, P. M., Rodríguez-Peralto, J. L., Ortiz-Romero, P., Tüting, T., Fisher, P. B. and Soengas, M. S. (2009). Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 16(2): 103-114.
  28. Murga, M., Bunting, S., Montaña, M. F., Soria, R., Mulero, F., Cañamero, M., Lee, Y., McKinnon, P. J., Nussenzweig, A. and Fernandez-Capetillo, O. (2009). A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet 41(8): 891-898.
  29. Fernandez-Rodriguez, O. M., Rios, A., Navarro, J. L., Pons, J. A., Palenciano, C. G., Mota, R., Berenguer, J. J., Mulero, F., Contreras, J., Conesa, C., Ramirez, P., Fuente, T., Parrilla, P. and Redes Tematicas de Investigacion Cooperativa: Estrategias para Optimizar los Resultados en Donacion y Trasplante, R. C. (2006). Doppler ultrasonographic and scintigraphic assessment of an auxiliary heterotopic liver transplantation with portal vein arterialization in pigs. Transplant Proc 38(3): 963-966.

Protocols by Francisca Mulero
  1. Analysis of Murine Lung Tumors by Micro PET-CT Imaging