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Chiara Ambrogio

Education

Ph.D. in Immunology and Cellular Biology, the Department of Biomedical Sciences and Human Oncology, University of Torino, 2008

Current position

Postdoc, Dr Barbacid Laboratory, Experimental Oncology Department, CNIO, Madrid, Spain (11/2009-present)

Publications

*Equally contributed

  1. Lopez-Contreras, A. J., Specks, J., Barlow, J. H., Ambrogio, C., Desler, C., Vikingsson, S., Rodrigo-Perez, S., Green, H., Rasmussen, L. J., Murga, M., Nussenzweig, A. and Fernandez-Capetillo, O. (2015). Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes Dev 29(7): 690-695.
  2. Voena, C., Menotti, M., Mastini, C., Di Giacomo, F., Longo, D. L., Castella, B., Merlo, M. E., Ambrogio, C., Wang, Q., Minero, V. G., Poggio, T., Martinengo, C., D'Amico, L., Panizza, E., Mologni, L., Cavallo, F., Altruda, F., Butaney, M., Capelletti, M., Inghirami, G., Jänne, P. A. and Chiarle, R. (2015). Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors. Cancer Immunol Res 3(12): 1333-1343.
  3. García-Beccaria, M., Martínez, P., Méndez-Pertuz, M., Martínez, S., Blanco-Aparicio, C., Cañamero, M., Mulero, F., Ambrogio, C., Flores, J. M., Megias, D., Barbacid, M., Pastor, J. and Blasco, M. A. (2015). Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage. EMBO Mol Med 7(7): 930-949.
  4. Ambrogio, C., Voena, C., Manazza, A. D., Piva, R., Riera, L., Barberis, L., Costa, C., Tarone, G., Defilippi, P., Hirsch, E., Boeri Erba, E., Mohammed, S., Jensen, O. N., Palestro, G., Inghirami, G. and Chiarle, R. (2005). p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood 106(12): 3907-3916.
  5. Martinengo, C., Poggio, T., Menotti, M., Scalzo, M. S., Mastini, C., Ambrogio, C., Pellegrino, E., Riera, L., Piva, R., Ribatti, D., Pastorino, F., Perri, P., Ponzoni, M., Wang, Q., Voena, C. and Chiarle, R. (2014). ALK-dependent control of hypoxia-inducible factors mediates tumor growth and metastasis. Cancer Res 74(21): 6094-6106.
  6. Ambrogio, C., Carmona, F. J., Vidal, A., Falcone, M., Nieto, P., Romero, O. A., Puertas, S., Vizoso, M., Nadal, E., Poggio, T., Sánchez-Céspedes, M., Esteller, M., Mulero, F., Voena, C., Chiarle, R., Barbacid, M., Santamaría, D. and Villanueva, A. (2014). Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. Cancer Res 74(21): 5978-5988.
  7. Ambrogio, C., Stern, P., Scuoppo, C., Kranz, H., Barbacid, M. and Santamaría, D. (2014). Lentiviral-based approach for the validation of cancer therapeutic targets in vivo. Biotechniques 57(4): 179, 181-177.
  8. Blasco, R. B., Karaca, E., Ambrogio, C., Cheong, T. C., Karayol, E., Minero, V. G., Voena, C. and Chiarle, R. (2014). Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology. Cell Rep 9(4): 1219-1227.
  9. Voena, C., Di Giacomo, F., Panizza, E., D'Amico, L., Boccalatte, F. E., Pellegrino, E., Todaro, M., Recupero, D., Tabbò, F., Ambrogio, C., Martinengo, C., Bonello, L., Pulito, R., Hamm, J., Chiarle, R., Cheng, M., Ruggeri, B., Medico, E. and Inghirami, G. (2013). The EGFR family members sustain the neoplastic phenotype of ALK+ lung adenocarcinoma via EGR1. Oncogenesis 2: e43.
  10. Piazza, R., Magistroni, V., Mogavero, A., Andreoni, F., Ambrogio, C., Chiarle, R., Mologni, L., Bachmann, P. S., Lock, R. B., Collini, P., Pelosi, G. and Gambacorti-Passerini, C. (2013). Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. Neoplasia 15(5): 511-522.
  11. Bosio, Y., Berto, G., Camera, P., Bianchi, F., Ambrogio, C., Claus, P. and Di Cunto, F. (2012). PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN. Eur J Cell Biol 91(8): 662-674.
  12. Di Paolo, D.*, Ambrogio, C.*, Pastorino, F., Brignole, C., Martinengo, C., Carosio, R., Loi, M., Pagnan, G., Emionite, L., Cilli, M., Ribatti, D., Allen, T. M., Chiarle, R., Ponzoni, M. and Perri, P. (2011). Selective therapeutic targeting of the anaplastic lymphoma kinase with liposomal siRNA induces apoptosis and inhibits angiogenesis in neuroblastoma. Mol Ther 19(12): 2201-2212.
  13. Boselli, D., Ragimbeau, J., Orlando, L., Cappello, P., Capello, M., Ambrogio, C., Chiarle, R., Marsili, G., Battistini, A., Giovarelli, M., Pellegrini, S. and Novelli, F. (2010). Expression of IFNgammaR2 mutated in a dileucine internalization motif reinstates IFNgamma signaling and apoptosis in human T lymphocytes. Immunol Lett 134(1): 17-25.
  14. Riera, L., Lasorsa, E., Ambrogio, C., Surrenti, N., Voena, C. and Chiarle, R. (2010). Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth. J Biol Chem 285(34): 26441-26450.
  15. Gonzalo, P., Guadamillas, M. C., Hernández-Riquer, M. V., Pollán, A., Grande-García, A., Bartolomé, R. A., Vasanji, A., Ambrogio, C., Chiarle, R., Teixidó, J., Risteli, J., Apte, S. S., del Pozo, M. S., and Arroyo, A. G. (2010). Membrane type 1-matrix metalloproteinase contributes to macrophage fusion through the regulation of the Rac1 signaling pathway. Dev Cell 18(1): 77-89.
  16. Ambrogio, C., Martinengo, C., Voena, C., Tondat, F., Riera, L., di Celle, P. F., Inghirami, G. and Chiarle, R. (2009). NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells. Cancer Res 69(22): 8611-8619.
  17. Barberis, L., Pasquali, C., Bertschy-Meier, D., Cuccurullo, A., Costa, C., Ambrogio, C., Vilbois, F., Chiarle, R., Wymann, M., Altruda, F., Rommel, C. and Hirsch, E. (2009). Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin. Eur J Immunol 39(4): 1136-1146.
  18. Ambrogio, C., Voena, C., Manazza, A. D., Martinengo, C., Costa, C., Kirchhausen, T., Hirsch, E., Inghirami, G. and Chiarle, R. (2008). The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res 68(21): 8899-8907.
  19. Crosetto, N., Bienko, M., Hibbert, R. G., Perica, T., Ambrogio, C., Kensche, T., Hofmann, K., Sixma, T. K. and Dikic, I. (2008). Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem 283(50): 35173-35185.
  20. Chiarle, R., Martinengo, C., Mastini, C., Ambrogio, C., D'Escamard, V., Forni, G. and Inghirami, G. (2008). The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination. Nat Med 14(6): 676-680.
  21. Chiarle, R., Voena, C., Ambrogio, C., Piva, R. and Inghirami, G. (2008). The anaplastic lymphoma kinase in the pathogenesis of cancer. Nat Rev Cancer 8(1): 11-23.
  22. Voena, C., Conte, C., Ambrogio, C., Boeri Erba, E., Boccalatte, F., Mohammed, S., Jensen, O. N., Palestro, G., Inghirami, G. and Chiarle, R. (2007). The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration. Cancer Res 67(9): 4278-4286.
  23. Berto, G., Camera, P., Fusco, C., Imarisio, S., Ambrogio, C., Chiarle, R., Silengo, L. and Di Cunto, F. (2007). The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J Cell Sci 120(Pt 11): 1859-1867.
  24. Costa, C., Barberis, L., Ambrogio, C., Manazza, A. D., Patrucco, E., Azzolino, O., Nielssen, P., Circolo, E., Altruda, F., Prestwich, G., Chiarle, R., Wymann, M., Ridley, A. and Hirsch, E. (2007). Constitutive elevation of phosphoinositide 3-Kinase γ activity in mice does not increase tumor susceptibility but reveals a negative feedback loop regulating Rac during leukocyte chemotaxis. PNAS 104(36):14354-9.
  25. Piva, R., Chiarle, R., Manazza, A. D., Taulli, R., Simmons, W., Ambrogio, C., D'Escamard, V., Pellegrino, E., Ponzetto, C., Palestro, G. and Inghirami, G. (2006). Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas. Blood 107(2): 689-697.
Protocols by Chiara Ambrogio
  1. Analysis of Murine Lung Tumors by Micro PET-CT Imaging