Education
Ph.D. in Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Portugal, 2001
Current position
Assistant Professor, Department of Life Sciences, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal (2015-present)
Head of the research group of Bacterial Cell Surfaces and Pathogenesis, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Portugal (2004-present)
Publications
*Co-first authors
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Monteiro, J. M., Fernandes, P. B., Vaz, F., Pereira, A. R., Tavares, A. C., Ferreira, M. T., Pereira, P. M., Veiga, H., Kuru, E., VanNieuwenhze, M. S., Brun, Y. V., Filipe, S. R. and Pinho, M. G. (2015). Cell shape dynamics during the staphylococcal cell cycle. Nat Commun 6: 8055.
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Greene, N. G., Narciso, A. R., Filipe, S. R. and Camilli, A. (2015). Peptidoglycan Branched Stem Peptides Contribute to Streptococcus pneumoniae Virulence by Inhibiting Pneumolysin Release. PLoS Pathog 11(6): e1004996.
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Carvalho, F., Atilano, M. L., Pombinho, R., Covas, G., Gallo, R. L., Filipe, S. R., Sousa, S. and Cabanes, D. (2015). L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane. PLoS Pathog 11(5): e1004919.
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Reed, P., Atilano, M. L., Alves, R., Hoiczyk, E., Sher, X., Reichmann, N. T., Pereira, P. M., Roemer, T., Filipe, S. R., Pereira-Leal, J. B., Ligoxygakis, P. and Pinho, M. G. (2015). Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance. PLoS Pathog 11(5): e1004891.
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Catalao, M. J., Figueiredo, J., Henriques, M. X., Gomes, J. P. and Filipe, S. R. (2014). Optimization of fluorescent tools for cell biology studies in Gram-positive bacteria. PLoS One 9(12): e113796.
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Atilano, M. L., Pereira, P. M., Vaz, F., Catalao, M. J., Reed, P., Grilo, I. R., Sobral, R. G., Ligoxygakis, P., Pinho, M. G. and Filipe, S. R. (2014). Bacterial autolysins trim cell surface peptidoglycan to prevent detection by the Drosophila innate immune system. Elife 3: e02277.
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Rueff, A. S., Chastanet, A., Dominguez-Escobar, J., Yao, Z., Yates, J., Prejean, M. V., Delumeau, O., Noirot, P., Wedlich-Soldner, R., Filipe, S. R. and Carballido-Lopez, R. (2014). An early cytoplasmic step of peptidoglycan synthesis is associated to MreB in Bacillus subtilis. Mol Microbiol 91(2): 348-362.
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Thorsing, M., Klitgaard, J. K., Atilano, M. L., Skov, M. N., Kolmos, H. J., Filipe, S. R. and Kallipolitis, B. H. (2013). Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300. PLoS One 8(5): e64518.
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Henriques, M. X.*, Catalao, M. J.*, Figueiredo, J., Gomes, J. P. and Filipe, S. R. (2013). Construction of improved tools for protein localization studies in Streptococcus pneumoniae. PLoS One 8(1): e55049.
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Atilano, M. L.^, Yates, J.^, Glittenberg, M.^, Filipe, S. R.* and Ligoxygakis, P.* (2011). Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. PLoS Pathog 7(12): e1002421.
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Henriques, M. X., Rodrigues, T., Carido, M., Ferreira, L. and Filipe, S. R. (2011). Synthesis of capsular polysaccharide at the division septum of Streptococcus pneumoniae is dependent on a bacterial tyrosine kinase. Mol Microbiol 82(2): 515-534.
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Atilano, M. L., Pereira, P. M., Yates, J., Reed, P., Veiga, H., Pinho, M. G. and Filipe, S. R.* (2010). Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus. Proc Natl Acad Sci U S A 107(44): 18991-18996.
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Memmi, G., Filipe, S. R., Pinho, M. G., Fu, Z. and Cheung, A. (2008). Staphylococcus aureus PBP4 is essential for beta-lactam resistance in community-acquired methicillin-resistant strains. Antimicrob Agents Chemother 52(11): 3955-3966.
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Wang, L., Gilbert, R. J., Atilano, M. L., Filipe, S. R., Gay, N. J. and Ligoxygakis, P. (2008). Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity. Proc Natl Acad Sci U S A 105(33): 11881-11886.
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Pereira, P. M., Filipe, S. R., Tomasz, A. and Pinho, M. G. (2007). Fluorescence ratio imaging microscopy shows decreased access of vancomycin to cell wall synthetic sites in vancomycin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 51(10): 3627-3633.
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Wang, L., Weber, A. N., Atilano, M. L., Filipe, S. R., Gay, N. J. and Ligoxygakis, P. (2006). Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. EMBO J 25(20): 5005-5014.
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Payne, B. T., van Knippenberg, I. C., Bell, H., Filipe, S. R., Sherratt, D. J. and McGlynn, P. (2006). Replication fork blockage by transcription factor-DNA complexes in Escherichia coli. Nucleic Acids Res 34(18): 5194-5202.
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Possoz, C.*, Filipe, S. R.*, Grainge, I. and Sherratt, D. J. (2006). Tracking of controlled Escherichia coli replication fork stalling and restart at repressor-bound DNA in vivo. EMBO J 25(11): 2596-2604.
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Filipe, S. R., Tomasz, A. and Ligoxygakis, P. (2005). Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway. EMBO Rep 6(4): 327-333.
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Gardete, S., Ludovice, A. M., Sobral, R. G., Filipe, S. R., de Lencastre, H. and Tomasz, A. (2004). Role of murE in the Expression of beta-lactam antibiotic resistance in Staphylococcus aureus. J Bacteriol 186(6): 1705-1713.
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Sherratt, D. J., Soballe, B., Barre, F. X., Filipe, S. R., Massey, T., Lau, I., and J. Yates. (2004). Recombination and chromosome segregation. Phil Trans R Soc Lond B 359: 61-69.
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Fiser, A., Filipe, S. R. and Tomasz, A. (2003). Cell wall branches, penicillin resistance and the secrets of the MurM protein. Trends Microbiol 11(12): 547-553.
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Lau, I. F., Filipe, S. R., Soballe, B., Okstad, O. A., Barre, F. X. and Sherratt, D. J. (2003). Spatial and temporal organization of replicating Escherichia coli chromosomes. Mol Microbiol 49(3): 731-743.
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Filipe, S. R., Severina, E. and Tomasz, A. (2002). The murMN operon: a functional link between antibiotic resistance and antibiotic tolerance in Streptococcus pneumoniae. Proc Natl Acad Sci U S A 99(3): 1550-1555.
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Filipe, S. R., Severina, E. and Tomasz, A. (2001). The role of murMN operon in penicillin resistance and antibiotic tolerance of Streptococcus pneumoniae. Microb Drug Resist 7(4): 303-316.
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Pinho, M. G., Filipe, S. R., de Lencastre, H. and Tomasz, A. (2001). Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus. J Bacteriol 183(22): 6525-6531.
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Filipe, S. R., Severina, E. and Tomasz, A. (2001). Functional analysis of Streptococcus pneumoniae MurM reveals the region responsible for its specificity in the synthesis of branched cell wall peptides. J Biol Chem 276(43): 39618-39628.
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Filipe, S. R., Severina, E. and Tomasz, A. (2000). Distribution of the mosaic structured murM genes among natural populations of Streptococcus pneumoniae. J Bacteriol 182(23): 6798-6805.
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Filipe, S. R., Pinho, M. G. and Tomasz, A. (2000). Characterization of the murMN operon involved in the synthesis of branched peptidoglycan peptides in Streptococcus pneumoniae. J Biol Chem 275(36): 27768-27774.
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Filipe, S. R. and Tomasz, A. (2000). Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes. Proc Natl Acad Sci U S A 97(9): 4891-4896.
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De Lencastre, H., Wu, S. W., Pinho, M. G., Ludovice, A. M., Filipe, S., Gardete, S., Sobral, R. and Gill, S. (1999). Antibiotic resistance as a stress response: Complete sequencing of a large number ofchromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance tomethicillin. Microb Drug Resist 5:163-175.