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Lucíola da Silva Barcelos


Ph.D. in Immunology, Federal University of Minas Gerais (UFMG-Brazil), 2005

Current position

Associate Professor in Physiology, Angiogenesis and Stem Cell lab, Department of Physiology and Biophysics, Federal University of Minas Gerais (UFMG), Belo Horizonte-MG, Brazil

Publications (since 2005)

  1. Cassini-Vieira, P., Araújo, F. A., da Costa Dias, F. L., Russo, R. C., Andrade, S. P., Teixeira, M. M. and Barcelos, L. S. (2015). iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants. Mediators of Inflammation 2015.
  2. Guedes-da-Silva, F. H., Shrestha, D., Salles, B. C., Figueiredo, V. P., Lopes, L. R., Dias, L., Barcelos Lda, S., Moura, S., de Andrade, S. P. and Talvani, A. (2015). Trypanosoma cruzi antigens induce inflammatory angiogenesis in a mouse subcutaneous sponge model. Microvasc Res 97: 130-136.
  3. Magalhaes, G. S., Rodrigues-Machado, M. G., Motta-Santos, D., Silva, A. R., Caliari, M. V., Prata, L. O., Abreu, S. C., Rocco, P. R., Barcelos, L. S., Santos, R. A. and Campagnole-Santos, M. J. (2015). Angiotensin-(1-7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation. Br J Pharmacol 172(9): 2330-2342.
  4. Silva, B., Sousa, L., Miranda, A., Vasconcelos, A., Reis, H., Barcelos, L., Arantes, R., Teixeira, A. and Rachid, M. A. (2015). Memory deficit associated with increased brain proinflammatory cytokine levels and neurodegeneration in acute ischemic stroke. Arq Neuropsiquiatr 73(8): 655-659.
  5. Silva, B. C., de Miranda, A. S., Rodrigues, F. G., Malheiros Silveira, A. L., de Souza Resende, G. H., Dutra Moraes, M. F., Pinheiro de Oliveira, A. C., Parreiras, P. M., da Silva Barcelos, L., Teixeira, M. M., Machado, F. S., Teixeira, A. L. and Rachid, M. A. (2015). The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia. Curr Neurovasc Res 12(4): 398-403.
  6. Canesso, M. C., Vieira, A. T., Castro, T. B., Schirmer, B. G., Cisalpino, D., Martins, F. S., Rachid, M. A., Nicoli, J. R., Teixeira, M. M. and Barcelos, L. S. (2014). Skin wound healing is accelerated and scarless in the absence of commensal microbiota. J Immunol 193(10): 5171-5180.
  7. Castro, P. R., Marques, S. M., Viana, C. T., Campos, P. P., Ferreira, M. A., Barcelos, L. S. and Andrade, S. P. (2014). Deletion of the chemokine receptor CCR2 attenuates foreign body reaction to implants in mice. Microvasc Res 95: 37-45.
  8. Cassini-Vieira, P., Deconte, S. R., Tomiosso, T. C., Campos, P. P., Montenegro Cde, F., Selistre-de-Araujo, H. S., Barcelos, L. S., Andrade, S. P. and Araujo Fde, A. (2014). DisBa-01 inhibits angiogenesis, inflammation and fibrogenesis of sponge-induced-fibrovascular tissue in mice. Toxicon 92: 81-89.
  9. Carmo, A. A., Costa, B. R., Vago, J. P., de Oliveira, L. C., Tavares, L. P., Nogueira, C. R., Ribeiro, A. L., Garcia, C. C., Barbosa, A. S., Brasil, B. S., Dusse, L. M., Barcelos, L. S., Bonjardim, C. A., Teixeira, M. M. and Sousa, L. P. (2014). Plasmin induces in vivo monocyte recruitment through protease-activated receptor-1-, MEK/ERK-, and CCR2-mediated signaling. J Immunol 193(7): 3654-3663.
  10. Campos-Junior, P. H., Costa, G. M., Avelar, G. F., Lacerda, S. M., da Costa, N. N., Ohashi, O. M., Miranda Mdos, S., Barcelos, L. S., Jorge, E. C., Guimaraes, D. A. and de Franca, L. R. (2014). Derivation of sperm from xenografted testis cells and tissues of the peccary (Tayassu tajacu). Reproduction 147(3): 291-299.
  11. Lima, L. D., Andrade, S. P., Campos, P. P., Barcelos, L. S., Soriani, F. M., Moura, S. A. and Ferreira, M. A. (2014). Brazilian green propolis modulates inflammation, angiogenesis and fibrogenesis in intraperitoneal implant in mice. BMC Complement Altern Med 14: 177.
  12. Almeida, S. A., Cardoso, C. C., Orellano, L. A., Reis, A. M., Barcelos, L. S. and Andrade, S. P. (2014). Natriuretic peptide clearance receptor ligand (C-ANP4-23 ) attenuates angiogenesis in a murine sponge implant model. Clin Exp Pharmacol Physiol 41(9): 691-697.
  13. Guabiraba, R., Russo, R. C., Coelho, A. M., Ferreira, M. A., Lopes, G. A., Gomes, A. K., Andrade, S. P., Barcelos, L. S. and Teixeira, M. M. (2013). Blockade of cannabinoid receptors reduces inflammation, leukocyte accumulation and neovascularization in a model of sponge-induced inflammatory angiogenesis. Inflamm Res 62(8): 811-821.
  14. Sousa, L. F., Coelho, F. M., Rodrigues, D. H., Campos, A. C., Barcelos Lda, S., Teixeira, M. M., Rachid, M. A. and Teixeira, A. L. (2013). Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice. Clinics (Sao Paulo) 68(3): 391-394.
  15. Borges, E. L., Oliveira, D. R. d., Barcelos, L. d. S. and Pesquero, J. L. (2013). Cytokine profile of rats fed a diet containing shrimp. Revista de Nutrição 26(1): 59-65.
  16. Bertini, R., Barcelos, L. S., Beccari, A. R., Cavalieri, B., Moriconi, A., Bizzarri, C., Di Benedetto, P., Di Giacinto, C., Gloaguen, I., Galliera, E., Corsi, M. M., Russo, R. C., Andrade, S. P., Cesta, M. C., Nano, G., Aramini, A., Cutrin, J. C., Locati, M., Allegretti, M. and Teixeira, M. M. (2012). Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2 non-competitive allosteric inhibitor. Br J Pharmacol 165(2): 436-454.
  17. Ignacio, C., Barcellos, L., Ferreira, M., Moura, S., Soares, I. and Oréfice, R. (2011). In vivo tests of a novel wound dressing based on biomaterials with tissue adhesion controlled through external stimuli. Journal of Materials Science: Materials in Medicine 22(5): 1357-1364.
  18. Russo, R. C., Garcia, C. C., Barcelos, L. S., Rachid, M. A., Guabiraba, R., Roffe, E., Souza, A. L., Sousa, L. P., Mirolo, M., Doni, A., Cassali, G. D., Pinho, V., Locati, M. and Teixeira, M. M. (2011). Phosphoinositide 3-kinase gamma plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice. J Leukoc Biol 89(2): 269-282.
  19. Barcelos, L. S. and Teixeira, M. M. (2011). Resetting gene expression in chronic Chagas heart disease. Cell Cycle 10(14): 2250. .
  20. Santos, I. C., Silbiger, V. N., Higuchi, D. A., Gomes, M. A., Barcelos, L. S., Teixeira, M. M., Lopes, M. T., Cardoso, V. N., Lima, M. P., Araujo, R. C., Pesquero, J. B. and Pesquero, J. L. (2010). Angiostatic activity of human plasminogen fragments is highly dependent on glycosylation. Cancer Sci 101(2): 453-459.
  21. Rachid, M. A., Teixeira, A. L., Barcelos, L. S., Machado, C. R., Chiari, E., Tanowitz, H. B., Camargos, E. R. and Teixeira, M. M. (2010). Role of endothelin receptors in the control of central nervous system parasitism in Trypanosoma cruzi infection in rats. J Neuroimmunol 220(1-2): 64-68.
  22. Rodrigues, D. H., Vilela, M. C., Barcelos, L. S., Pinho, V., Teixeira, M. M. and Teixeira, A. L. (2010). Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis. J Neuroimmunol 222(1-2): 90-94.
  23. Barcelos, L. S., Duplaa, C., Krankel, N., Graiani, G., Invernici, G., Katare, R., Siragusa, M., Meloni, M., Campesi, I., Monica, M., Simm, A., Campagnolo, P., Mangialardi, G., Stevanato, L., Alessandri, G., Emanueli, C. and Madeddu, P. (2009). Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res 104(9): 1095-1102.
  24. Talvani, A., Coutinho, S. F., da Silva Barcelos, L. and Teixeira, M. M. (2009). Cyclic AMP decreases the production of NO and CCL2 by macrophages stimulated with Trypanosoma cruzi GPI-mucins. Parasitology research 104(5): 1141-1148.
  25. Stone, O. A., Richer, C., Emanueli, C., van Weel, V., Quax, P. H., Katare, R., Kraenkel, N., Campagnolo, P., Barcelos, L. S., Siragusa, M., Sala-Newby, G. B., Baldessari, D., Mione, M., Vincent, M. P., Benest, A. V., Al Haj Zen, A., Gonzalez, J., Bates, D. O., Alhenc-Gelas, F. and Madeddu, P. (2009). Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Arterioscler Thromb Vasc Biol 29(5): 657-664.
  26. Barcelos, L. S., Coelho, A. M., Russo, R. C., Guabiraba, R., Souza, A. L., Bruno-Lima, G., Jr., Proudfoot, A. E., Andrade, S. P. and Teixeira, M. M. (2009). Role of the chemokines CCL3/MIP-1 alpha and CCL5/RANTES in sponge-induced inflammatory angiogenesis in mice. Microvasc Res 78(2): 148-154.
  27. Soares, J. A., Leite, F. G., Andrade, L. G., Torres, A. A., De Sousa, L. P., Barcelos, L. S., Teixeira, M. M., Ferreira, P. C., Kroon, E. G., Souto-Padron, T. and Bonjardim, C. A. (2009). Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication. J Virol 83(13): 6883-6899.
  28. Russo, R. C., Guabiraba, R., Garcia, C. C., Barcelos, L. S., Roffe, E., Souza, A. L., Amaral, F. A., Cisalpino, D., Cassali, G. D., Doni, A., Bertini, R. and Teixeira, M. M. (2009). Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol 40(4): 410-421.
  29. Krankel, N., Katare, R. G., Siragusa, M., Barcelos, L. S., Campagnolo, P., Mangialardi, G., Fortunato, O., Spinetti, G., Tran, N., Zacharowski, K., Wojakowski, W., Mroz, I., Herman, A., Manning Fox, J. E., MacDonald, P. E., Schanstra, J. P., Bascands, J. L., Ascione, R., Angelini, G., Emanueli, C. and Madeddu, P. (2008). Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res 103(11): 1335-1343.
  30. Pereira, R. M., dos Santos, R. A., Oliveira, E. A., Leite, V. H., Dias, F. L., Rezende, A. S., Costa, L. P., Barcelos, L. S., Teixeira, M. M. and Simoes e Silva, A. C. (2008). Development of hepatorenal syndrome in bile duct ligated rats. World J Gastroenterol 14(28): 4505-4511.
  31. Cristofaro, B., Caporali, A., Meloni, M., Sala-Newby, G. B., Barcelos, L. S., Madeddu, P. and Emanueli, C. (2008). Neurotrophin-3 (NT-3) promotes reparative neovascularization and blood flow recovery in a mouse model of limb ischemia. Atherosclerosis 199(2): 464.
  32. Pereira, R. M., Dos Santos, R. A., Teixeira, M. M., Leite, V. H., Costa, L. P., da Costa Dias, F. L., Barcelos, L. S., Collares, G. B. and Simoes e Silva, A. C. (2007). The renin-angiotensin system in a rat model of hepatic fibrosis: evidence for a protective role of Angiotensin-(1-7). J Hepatol 46(4): 674-681.
  33. Roffe, E., Souza, A. L., Machado, P. P., Barcelos, L. S., Romanha, A. J., Mariano, F. S., Silva, J. S., Machado, C. R., Tanowitz, H. B. and Teixeira, M. M. (2007). Endothelin-1 receptors play a minor role in the protection against acute Trypanosoma cruzi infection in mice. Braz J Med Biol Res 40(3): 391-399..
  34. Ferreira, M. A., Barcelos, L. S., Teixeira, M. M., Bakhle, Y. S. and Andrade, S. P. (2007). Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). Life Sci 81(3): 210-217.
  35. Madeddu, P., Kraenkel, N., Barcelos, L. S., Siragusa, M., Campagnolo, P., Oikawa, A., Caporali, A., Herman, A., Azzolino, O., Barberis, L., Perino, A., Damilano, F., Emanueli, C. and Hirsch, E. (2008). Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions. Arterioscler Thromb Vasc Biol 28(1): 68-76.
  36. Teixeira, A. S., Araujo, F. A., Ferreira, M. A., Barcelos, L. S., Teixeira, M. M. and Andrade, S. P. (2006). Angiogenesis and inflammation in skeletal muscle in response to ascites tumor in mice. Life Sci 78(14): 1637-1645.
  37. Rachid, M. A., Camargos, E. R., Barcellos, L., Marques, C. A., Chiari, E., Huang, H., Tanowitz, H. B., Teixeira, M. M. and Machado, C. R. (2006). Blockade of endothelin ET A/ET B receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. Microbes and infection 8(8): 2113-2119.
  38. Roffe, E., Souza, A. L., Caetano, B. C., Machado, P. P., Barcelos, L. S., Russo, R. C., Santiago, H. C., Souza, D. G., Pinho, V., Tanowitz, H. B., Camargos, E. R., Bruna-Romero, O. and Teixeira, M. M. (2006). A DNA vaccine encoding CCL4/MIP-1beta enhances myocarditis in experimental Trypanosoma cruzi infection in rats. Microbes Infect 8(12-13): 2745-2755.
  39. Barcelos, L. S., Talvani, A., Teixeira, A. S., Vieira, L. Q., Cassali, G. D., Andrade, S. P. and Teixeira, M. M. (2005). Impaired inflammatory angiogenesis, but not leukocyte influx, in mice lacking TNFR1. J Leukoc Biol 78(2): 352-358.
  40. Belo, A. V., Leles, F., Barcelos, L. S., Ferreira, M. A., Bakhle, Y. S., Teixeira, M. M. and Andrade, S. P. (2005). Murine chemokine CXCL2/KC is a surrogate marker for angiogenic activity in the inflammatory granulation tissue. Microcirculation 12(7): 597-606.
Protocols by Lucíola da Silva Barcelos
  1. Skin Wound Healing Model - Excisional Wounding and Assessment of Lesion Area
  2. Estimation of Wound Tissue Neutrophil and Macrophage Accumulation by Measuring Myeloperoxidase (MPO) and N-Acetyl-β-D-glucosaminidase (NAG) Activities