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William C. W. Chen


Ph.D. in Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA, 2012

Current position

Postdoctoral Associate, Research Laboratory of Electronics and Dept. of Biological Engineering, Massachusetts Institute of Technology (2015-now)


  1. Chen, W. C., Lee, B. G., Park, D. W., Kim, K., Chu, H., Kim, K., Huard, J. and Wang, Y. (2015). Controlled dual delivery of fibroblast growth factor-2 and Interleukin-10 by heparin-based coacervate synergistically enhances ischemic heart repair. Biomaterials 72: 138-151.
  2. Chen, W. C.*, Péault, B. and Huard, J. (2015). Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors. Stem Cells Int 2015: 375187. (*Corresponding author)
  3. Proto, J. D., Tang, Y.*, Lu, A.*, Chen, W. C.*, Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. and Huard, J. (2015). NF-kappaB inhibition reveals a novel role for HGF during skeletal muscle repair. Cell Death Dis 6: e1730. (*Co-second author)
  4. Chen, W. C.*, Baily, J. E.*, Corselli, M., Diaz, M. E., Sun, B., Xiang, G., Gray, G. A., Huard, J. and Peault, B. (2015). Human myocardial pericytes: multipotent mesodermal precursors exhibiting cardiac specificity. Stem Cells 33(2): 557-573. (*Co-corresponding author)
  5. Gao, X., Usas, A., Proto, J. D., Lu, A., Cummins, J. H., Proctor, A., Chen, C. W. and Huard, J. (2014). Role of donor and host cells in muscle-derived stem cell-mediated bone repair: differentiation vs. paracrine effects. FASEB J 28(8): 3792-3809.
  6. Chen, W. C., Saparov, A., Corselli, M., Crisan, M., Zheng, B., Peault, B. and Huard, J. (2014). Isolation of blood-vessel-derived multipotent precursors from human skeletal muscle. J Vis Exp (90): e51195.
  7. Beckman, S. A., Sekiya, N.*, Chen, W. C.*, Mlakar, L., Tobita, K. and Huard, J. (2014). The cardiac regenerative potential of myoblasts remains limited despite improving their survival via antioxidant treatment. CellvR4 2(2): e845. (*Co-second author)
  8. Bodnar, R. J., Rodgers, M. E., Chen, W. C. and Wells, A. (2013). Pericyte regulation of vascular remodeling through the CXC receptor 3. Arterioscler Thromb Vasc Biol 33(12): 2818-2829.
  9. Saparov, A., Chen, C. W., Beckman, S. A., Wang, Y. and Huard, J. (2013). The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair. Int J Mol Sci 14(8): 16258-16279.
  10. Chen, W. C., Park, T. S., Murray, I. R., Zimmerlin, L., Lazzari, L., Huard, J. and Peault, B. (2013). Cellular kinetics of perivascular MSC precursors. Stem Cells Int 2013: 983059.
  11. Li, H., Usas, A., Poddar, M., Chen, C. W., Thompson, S., Ahani, B., Cummins, J., Lavasani, M. and Huard, J. (2013). Platelet-rich plasma promotes the proliferation of human muscle derived progenitor cells and maintains their stemness. PLoS One 8(6): e64923.
  12. Zheng, B., Li, G., Chen, W. C., Deasy, B. M., Pollett, J. B., Sun, B., Drowley, L., Gharaibeh, B., Usas, A., Peault, B. and Huard, J. (2013). Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level. J Orthop Res 31(7): 1089-1095.
  13. Gao, X., Usas, A., Lu, A., Tang, Y., Wang, B., Chen, C. W., Li, H., Tebbets, J. C., Cummins, J. H. and Huard, J. (2013). BMP2 is superior to BMP4 for promoting human muscle-derived stem cell-mediated bone regeneration in a critical-sized calvarial defect model. Cell Transplant 22(12): 2393-2408.
  14. Chen, C. W., Okada, M., Proto, J. D., Gao, X., Sekiya, N., Beckman, S. A., Corselli, M., Crisan, M., Saparov, A., Tobita, K., Peault, B. and Huard, J. (2013). Human pericytes for ischemic heart repair. Stem Cells 31(2): 305-316.
  15. Chu, H., Chen, C. W., Huard, J. and Wang, Y. (2013). The effect of a heparin-based coacervate of fibroblast growth factor-2 on scarring in the infarcted myocardium. Biomaterials 34(6): 1747-1756.
  16. Chen, W. C. and Péault, B. (2013). Stem Cells: Development and renewal of ventricular heart muscle from intrinsic progenitor cells. In: Meyers, R. A. (ed). Encyclopedia of Molecular Cell Biology and Molecular Medicine. Wiley-VCH Verlag GmbH & Co., Hoboken.
  17. Chen, C. W.*, Huard, J. and Péault, B. (2012). Mesenchymal stem cells and cardiovascular repair. In: Xiao, Y. (ed). Mesenchymal Stem Cells. Nova Science: 363-378. (*Corresponding author)
  18. Gerlach, J. C., Over, P., Turner, M. E., Thompson, R. L., Foka, H. G., Chen, W. C., Peault, B., Gridelli, B. and Schmelzer, E. (2012). Perivascular mesenchymal progenitors in human fetal and adult liver. Stem Cells Dev 21(18): 3258-3269.
  19. Crisan, M., Corselli, M.*, Chen, W. C.* and Peault, B. (2012). Perivascular cells for regenerative medicine. J Cell Mol Med 16(12): 2851-2860. (*Co-second author)
  20. Chen, C. W.*, Corselli, M., Peault, B. and Huard, J. (2012). Human blood-vessel-derived stem cells for tissue repair and regeneration. J Biomed Biotechnol 2012: 597439. (*Corresponding author)
  21. Zheng, B.*, Chen, C. W.*, Li, G., Thompson, S. D., Poddar, M., Peault, B. and Huard, J. (2012). Isolation of myogenic stem cells from cultures of cryopreserved human skeletal muscle. Cell Transplant 21(6): 1087-1093. (*Co-first author)
  22. Corselli, M., Chen, C. W., Sun, B., Yap, S., Rubin, J. P. and Peault, B. (2012). The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells. Stem Cells Dev 21(8): 1299-1308.
  23. Okada, M., Payne, T. R., Drowley, L., Jankowski, R. J., Momoi, N., Beckman, S., Chen, W. C., Keller, B. B., Tobita, K. and Huard, J. (2012). Human skeletal muscle cells with a slow adhesion rate after isolation and an enhanced stress resistance improve function of ischemic hearts. Mol Ther 20(1): 138-145.
  24. Chu, H., Gao, J.*, Chen, C. W.*, Huard, J. and Wang, Y. (2011). Injectable fibroblast growth factor-2 coacervate for persistent angiogenesis. Proc Natl Acad Sci U S A 108(33): 13444-13449. (*Co-second author)
  25. Crisan, M., Corselli, M., Chen, C. W. and Peault, B. (2011). Multilineage stem cells in the adult: a perivascular legacy? Organogenesis 7(2): 101-104.
  26. Xiang, G., Yang, Q., Wang, B., Sekiya, N., Mu, X., Tang, Y., Chen, C. W., Okada, M., Cummins, J., Gharaibeh, B. and Huard, J. (2011). Lentivirus-mediated Wnt11 gene transfer enhances Cardiomyogenic differentiation of skeletal muscle-derived stem cells. Mol Ther 19(4): 790-796.
  27. Park, T. S., Gavina, M.*, Chen, C. W.*, Sun, B., Teng, P. N., Huard, J., Deasy, B. M., Zimmerlin, L. and Peault, B. (2011). Placental perivascular cells for human muscle regeneration. Stem Cells Dev 20(3): 451-463. (*Co-second author)
  28. Lin, C. H., Hsu, S. H., Su, J. M. and Chen, C. W. (2011). Surface modification of poly(epsilon-caprolactone) porous scaffolds using gelatin hydrogel as the tracheal replacement. J Tissue Eng Regen Med 5(2): 156-162.
  29. Corselli, M., Chen, C. W., Crisan, M., Lazzari, L. and Peault, B. (2010). Perivascular ancestors of adult multipotent stem cells. Arterioscler Thromb Vasc Biol 30(6): 1104-1109.
  30. Chen, C. W., Montelatici, E., Crisan, M., Corselli, M., Huard, J., Lazzari, L. and Peault, B. (2009). Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both? Cytokine Growth Factor Rev 20(5-6): 429-434.
  31. Crisan, M., Chen, C. W., Corselli, M., Andriolo, G., Lazzari, L. and Peault, B. (2009). Perivascular multipotent progenitor cells in human organs. Ann N Y Acad Sci 1176: 118-123.
  32. Crisan, M., Yap, S., Casteilla, L., Chen, C. W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P. N., Traas, J., Schugar, R., Deasy, B. M., Badylak, S., Buhring, H. J., Giacobino, J. P., Lazzari, L., Huard, J. and Peault, B. (2008). A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3): 301-313.
  33. Liu, C., Chen, C. W. and Ducheyne, P. (2008). In vitro surface reaction layer formation and dissolution of calcium phosphate cement-bioactive glass composites. Biomed Mater 3(3): 034111.
  34. Liu, C., Chen, C. W. and Ducheyne, P. (2007). Effects of the composition of the bioactive composite calcium phosphate cement on its behavior in the solution. In: Key Engineering Materials. Trans Tech Publications: 823-826.
Protocols by William C. W. Chen
  1. Skeletal Myogenesis in vitro