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Francisco Martín


Ph.D. in Biologia molecular, Universidad de Granada, Granada, Andalusia, Spain, 1994

Current position

Team Leader, Department of human genetic variability, GENYO (since 2009)


  1. Carrillo-Gálvez, A. B., Cobo, M., Cuevas-Ocaña, S., Gutiérrez-Guerrero, A., Sánchez-Gilabert, A., Bongarzone, P., Garcia-Perez, A., Muñoz, P., Benabdellah, K., Toscano, M. G., Martín, F. and Anderson, P. (2015). Mesenchymal stromal cells express GARP/LRRC32 on their surface: effects on their biology and immunomodulatory capacity. Stem Cells 33(1): 183-195.
  2. Toscano, M. G., Navarro-Montero, O., Ayllon, V., Ramos-Mejia, V., Guerrero-Carreno, X., Bueno, C., Romero, T., Lamolda, M., Cobo, M., Martin, F.*, Menendez, P.* and Real, P. J.* (2015). SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. Mol Ther 23(1): 158-170.
  3. Toscano, M. G., Navarro-Montero, O., Ayllon, V., Ramos-Mejia, V., Guerrero-Carreno, X., Bueno, C., Romero, T., Lamolda, M., Cobo, M., Martin, F.*, Menendez, P.* and Real, P. J.* (2015). SCL/TAL1-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells. Mol Ther 23(1): 158-170. *Share senior authorship.
  4. Benabdellah, K., Gutierrez-Guerrero, A., Cobo, M., Muñoz, P. and Martín, F. (2014). A chimeric HS4-SAR insulator (IS2) that prevents silencing and enhances expression of lentiviral vectors in pluripotent stem cells. PLoS One 9(1): e84268.
  5. Muñoz-Fernández, R., Prados, A., Tirado-González, I., Martín, F., Abadía, A. C. and Olivares, E. G. (2014). Contractile activity of human follicular dendritic cells. Immunol Cell Biol 92(10): 851-859.
  6. Hernández-Cortés, P., Toledo-Romero, M. A., Delgado, M., Sánchez-González, C. E., Martin, F., Galindo-Moreno, P. and O'Valle, F. (2014). Peripheral nerve reconstruction with epsilon-caprolactone conduits seeded with vasoactive intestinal peptide gene-transfected mesenchymal stem cells in a rat model. J Neural Eng 11(4): 046024.
  7. Escolano, A., Martinez-Martinez, S., Alfranca, A., Urso, K., Izquierdo, H. M., Delgado, M., Martin, F., Sabio, G., Sancho, D., Gomez-del Arco, P. and Redondo, J. M. (2014). Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP-1 and p38. EMBO J 33(10): 1117-1133.
  8. Aguilar, E.*, Cobo, M.* and Martin, F.* (2013). Gene-modified mesenchymal stem cells:A VIP experience. Inflammation & Regeneration 34(4). *Share authorship
  9. Anderson, P., Carrillo-Gálvez, A. B., García-Peréz, A., Cobo, M. and Martín, F. (2013). CD105 (endoglin)-negative murine mesenchymal stromal cells define a new multipotent subpopulation with distinct differentiation and immunomodulatory capacities. PLoS One 8(10): e76979.
  10. Cobo, M., Anderson, P., Benabdellah, K., Toscano, M. G., Muñoz, P., Garcia-Peréz, A., Gutierrez, I., Delgado, M. and Martin, F. (2013). Mesenchymal stem cells expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple sclerosis. Cell Transplant 22(5): 839-854.
  11. Toscano, M. G., Anderson, P., Muñoz, P., Lucena, G., Cobo, M., Benabdellah, K., Gregory, P. D., Holmes, M. C. and Martin, F. (2013). Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome. Dis Mod Mech 6(2): 544 - 598.
  12. Tirado-González, I., Muñoz-Fernández, R., Prados, A., Leno-Durán, E., Martin, F., Abadia-Molina, A. C. and Olivares, E. G. (2012). Apoptotic DC-SIGN+ cells in normal human decidua. Placenta 33(4): 257-263.
  13. Ramos-Mejía, V., Fernández, A. F., Ayllón, V., Real, P. J., Bueno, C., Anderson, P., Martín, F., Fraga, M. F. and Menendez, P. (2012). Maintenance of human embryonic stem cells in mesenchymal stem cell-conditioned media augments hematopoietic specification. Stem Cells Dev 21(9): 1549-1558.
  14. Muñoz, P., Toscano, M. G., Real, P. J., Benabdellah, K., Cobo, M., Bueno, C., Ramos-Mejía, V., Menendez, P., Anderson, P. and Martín, F. (2012). Specific marking of hESCs-derived hematopoietic lineage by WAS-promoter driven lentiviral vectors. PLoS One 7(6): e39091.
  15. Guadalupe Zaldívar Lelo de Larrea, Martin, F., Carlos Francisco Sosa Ferreyra, Javier Ávila Morales, Miguel Lloret Rivas, Monserrat Román Lara and Genaro Vega Malagón. (2012). Cáncer cérvicouterino y virus del papiloma humano. Revista chilena de obstetricia y ginecología 77(4): 315 - 323.
  16. Toscano, M. G., Romero, Z., Muñoz, P., Cobo, M., Benabdellah, K. and Martin, F. (2011). Physiological and tissue-specific vectors for treatment of inherited diseases. Gene Ther 18(2): 117-127.
  17. Romero, Z., Torres, S., Cobo, M., Muñoz, P., Unciti, J. D., Martin, F.* and Molina, I. J.* (2011). A tissue-specific, activation-inducible, lentiviral vector regulated by human CD40L proximal promoter sequences. Gene Ther 18(4): 364-371.
  18. Benabdellah, K., Cobo, M., Muñoz, P., Toscano, M. G. and Martin, F.* (2011). Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines. PLoS One 6(8): e23734.
  19. Toscano, M. G., Delgado, M., Kong, W., Martin, F., Skarica, M. and Ganea, D. (2010). Dendritic cells transduced with lentiviral vectors expressing VIP differentiate into VIP-secreting tolerogenic-like DCs. Mol Ther 18(5): 1035-1045.
  20. Macias, D., Oya, R., Saniger, L., Martin, F. and Luque, F. (2009). A lentiviral vector that activates latent human immunodeficiency virus-1 proviruses by the overexpression of tat and that kills the infected cells. Hum Gene Ther 20(11): 1259-1268.
  21. Romero, Z., Toscano, M. G., Unciti, J. D., Molina, I. and Martin, F. (2009). Safer vectors for gene therapy of primary immunodeficiencies. Curr Gene Ther 9(4): 291-305.
  22. Toscano, M. G., Benabdellah, K., Muñoz, P., Frecha, C., Cobo, M. and Martín, F. (2009). Was cDNA sequences modulate transgene expression of was promoter-driven lentiviral vectors. Human Gene Therapy 20(11): 1279-1369.
  23. Frecha, C., Toscano, M. G., Costa, C., Saez-Lara, M. J., Cosset, F. L., Verhoeyen, E. and Martin, F. (2008). Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Gene Ther 15(12): 930-941.
  24. Delgado, M., Toscano, M. G., Benabdellah, K., Cobo, M., O'Valle, F., Gonzalez-Rey, E. and Martín, F. (2008). In vivo delivery of lentiviral vectors expressing vasoactive intestinal peptide complementary DNA as gene therapy for collagen-induced arthritis. Arthritis Rheum 58(4): 1026-1037.
  25. Toscano, M. G., Frecha, C., Benabdellah, K., Cobo, M., Blundell, M., Thrasher, A. J., Garcia-Olivares, E., Molina, I. J. and Martin, F. (2008). Hematopoietic-specific lentiviral vectors circumvent cellular toxicity due to ectopic expression of Wiskott-Aldrich syndrome protein. Hum Gene Ther 19(2): 179-197.
  26. Artritis gene therpay by in vivo delivery of lentiviral vectors expressing vasoactive intestinal peptidecDNA. Arthritis Rheu: 1026 - 1038. 2008.
  27. Munoz-Fernandez, R., Blanco, F. J., Frecha, C., Martín, F., Kimatrai, M., Abadía-Molina, A. C., García-Pacheco, J. M. and Olivares, E. G. (2006). Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts. J Immunol 177(1): 280-289.
  28. Sáez-Lara, M. J., Frecha, C., Martín, F., Abadía, F., Toscano, M., Gil, A. and Fontana, L. (2006). Transplantation of human CD34+ stem cells from umbilical cord blood to rats with thioacetamide-induced liver cirrhosis. Xenotransplantation 13(6): 529-535.
  29. Chan, L., Nesbeth, D., Mackey, T., Galea-Lauri, J., Gäken, J., Martin, F., Collins, M., Mufti, G., Farzaneh, F. and Darling, D. (2005). Conjugation of lentivirus to paramagnetic particles via nonviral proteins allows efficient concentration and infection of primary acute myeloid leukemia cells. J Virol 79(20): 13190-13194.
  30. Kimatrai, M., Blanco, O., Muñoz-Fernandez, R., Tirado, I., Martin, F., Abadía-Molina, A. C. and Olivares, E. G. (2005). Contractile activity of human decidual stromal cells. II. Effect of interleukin-10. J Clin Endocrinol Metab 90(11): 6126-6130.
  31. Martin, F., Toscano, M. G., Blundell, M., Frecha, C., Srivastava, G. K., Santamaria, M., Thrasher, A. J. and Molina, I. J. (2005). Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences. Gene Ther 12(8): 715-723.
    * Senior and corresponding
Protocols by Francisco Martín
  1. Isolation of Murine Adipose Tissue-derived Mesenchymal Stromal Cells (mASCs) and the Analysis of Their Proliferation in vitro