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Adam Hurlstone


Ph.D., Cancer Research UK Beatson Institute for Cancer Research, 1998

Current position

Senior Lecturer at The University of Manchester, Faculty of Life Sciences

Publications (since 2005)

  1. Paul, N. R., Allen, J. L., Chapman, A., Morlan-Mairal, M., Zindy, E., Jacquemet, G., Fernandez Del Ama, L., Ferizovic, N., Green, D. M., Howe, J. D., Ehler, E., Hurlstone, A. and Caswell, P. T. (2015). alpha5beta1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3. J Cell Biol 210(6): 1013-1031.
  2. Herrero, A., Pinto, A., Colon-Bolea, P., Casar, B., Jones, M., Agudo-Ibanez, L., Vidal, R., Tenbaum, S. P., Nuciforo, P., Valdizan, E. M., Horvath, Z., Orfi, L., Pineda-Lucena, A., Bony, E., Keri, G., Rivas, G., Pazos, A., Gozalbes, R., Palmer, H. G., Hurlstone, A. and Crespo, P. (2015). Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 28(2): 170-182.
  3. Vaughan, L., Tan, C. T., Chapman, A., Nonaka, D., Mack, N. A., Smith, D., Booton, R., Hurlstone, A. F. and Malliri, A. (2015). HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion. Cell Rep 10(1): 88-102.
  4. Chapman, A., Fernandez del Ama, L., Ferguson, J., Kamarashev, J., Wellbrock, C. and Hurlstone, A. (2014). Heterogeneous tumor subpopulations cooperate to drive invasion. Cell Rep 8(3): 688-695.
  5. Burgon, J., Robertson, A. L., Sadiku, P., Wang, X., Hooper-Greenhill, E., Prince, L. R., Walker, P., Hoggett, E. E., Ward, J. R., Farrow, S. N., Zuercher, W. J., Jeffrey, P., Savage, C. O., Ingham, P. W., Hurlstone, A. F., Whyte, M. K. and Renshaw, S. A. (2014). Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. J Immunol 192(4): 1796-1805.
  6. Dalton, L. E., Kamarashev, J., Barinaga-Rementeria Ramirez, I., White, G., Malliri, A. and Hurlstone, A. (2013). Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. J Invest Dermatol 133(6): 1572-1581.
  7. Smith, M. P., Ferguson, J., Arozarena, I., Hayward, R., Marais, R., Chapman, A., Hurlstone, A. and Wellbrock, C. (2013). Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma. J Natl Cancer Inst 105(1): 33-46.
  8. Ramirez, I. B., Pietka, G., Jones, D. R., Divecha, N., Alia, A., Baraban, S. C., Hurlstone, A. F. and Lowe, M. (2012). Impaired neural development in a zebrafish model for Lowe syndrome. Hum Mol Genet 21(8): 1744-1759.
  9. Haud, N., Kara, F., Diekmann, S., Henneke, M., Willer, J. R., Hillwig, M. S., Gregg, R. G., Macintosh, G. C., Gartner, J., Alia, A. and Hurlstone, A. F. (2011). rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proc Natl Acad Sci U S A 108(3): 1099-1103.
  10. Santoriello, C., Gennaro, E., Anelli, V., Distel, M., Kelly, A., Koster, R. W., Hurlstone, A. and Mione, M. (2010). Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish. PLoS One 5(12): e15170.
  11. Feng, Y., Santoriello, C., Mione, M., Hurlstone, A.* and Martin, P. (2010). Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol 8(12): e1000562.( *co-corresponding author)
  12. Nicoli, S., Standley, C., Walker, P., Hurlstone, A., Fogarty, K. E. and Lawson, N. D. (2010). MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature 464(7292): 1196-1200.
  13. Michailidou, C., Jones, M., Walker, P., Kamarashev, J., Kelly, A. and Hurlstone, A. F. (2009). Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Dis Model Mech 2(7-8): 399-411.
  14. Muncan, V., Faro, A., Haramis, A. P., Hurlstone, A. F., Wienholds, E., van Es, J., Korving, J., Begthel, H., Zivkovic, D. and Clevers, H. (2007). T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine. EMBO Rep 8(10): 966-973.
  15. Haramis, A. P., Hurlstone, A., van der Velden, Y., Begthel, H., van den Born, M., Offerhaus, G. J. and Clevers, H. C. (2006). Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. EMBO Rep 7(4): 444-449.
  16. Malliri, A., Rygiel, T. P., van der Kammen, R. A., Song, J. Y., Engers, R., Hurlstone, A. F., Clevers, H. and Collard, J. G. (2006). The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. J Biol Chem 281(1): 543-548.
Protocols by Adam Hurlstone
  1. Differentiation of THP1 Cells into Macrophages for Transwell Co-culture Assay with Melanoma Cells