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Naoki Tanimizu


Ph.D. in Agriculture, Department of Agriculture Kyoto University, 1999

Current position

Associate Professor, Sapporo Medical University School of Medicine


  1. Tanimizu, N., Kobayashi, S., Ichinohe, N. and Mitaka, T. (2014). Downregulation of miR122 by grainyhead-like 2 restricts the hepatocytic differentiation potential of adult liver progenitor cells. Development 141(23): 4448-4456.
  2. Kikkawa, Y., Miwa, T., Tanimizu, N., Kadoya, Y., Ogawa, T., Katagiri, F., Hozumi, K., Nomizu, M., Mizuguchi, T., Hirata, K. and Mitaka, T. (2014). Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511 in vitro. Exp Cell Res 328(1): 197-206.
  3. Tanimizu, N., Nishikawa, Y., Ichinohe, N., Akiyama, H. and Mitaka, T. (2014). Sry HMG box protein 9-positive (Sox9+) epithelial cell adhesion molecule-negative (EpCAM-) biphenotypic cells derived from hepatocytes are involved in mouse liver regeneration. J Biol Chem 289(11): 7589-7598.
  4. Nakamura, Y., Mizuguchi, T., Tanimizu, N., Ichinohe, N., Ooe, H., Kawamoto, M., Meguro, M., Hirata, K. and Mitaka, T. (2014). Preoperative hepatocyte transplantation improves the survival of rats with nonalcoholic steatohepatitis-related cirrhosis after partial hepatectomy. Cell Transplant 23(10): 1243-1254.
  5. Tanimizu, N. and Mitaka, T. (2014). Re-evaluation of liver stem/progenitor cells. Organogenesis 10(2): 208-215.
  6. Tanimizu, N., Nakamura, Y., Ichinohe, N., Mizuguchi, T., Hirata, K. and Mitaka, T. (2013). Hepatic biliary epithelial cells acquire epithelial integrity but lose plasticity to differentiate into hepatocytes in vitro during development. J Cell Sci 126(Pt 22): 5239-5246.
  7. Tanimizu, N. and Mitaka, T. (2013). Role of grainyhead-like 2 in the formation of functional tight junctions. Tissue Barriers 1(1): e23495.
  8. Kiyohashi, K., Kakinuma, S., Kamiya, A., Sakamoto, N., Nitta, S., Yamanaka, H., Yoshino, K., Fujiki, J., Murakawa, M., Kusano-Kitazume, A., Shimizu, H., Okamoto, R., Azuma, S., Nakagawa, M., Asahina, Y., Tanimizu, N., Kikuchi, A., Nakauchi, H. and Watanabe, M. (2013). Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology 57(6): 2502-2513.
  9. Ichinohe, N., Tanimizu, N., Ooe, H., Nakamura, Y., Mizuguchi, T., Kon, J., Hirata, K. and Mitaka, T. (2013). Differentiation capacity of hepatic stem/progenitor cells isolated from D-galactosamine-treated rat livers. Hepatology 57(3): 1192-1202.
  10. Tanimizu, N., Kikkawa, Y., Mitaka, T. and Miyajima, A. (2012). alpha1- and alpha5-containing laminins regulate the development of bile ducts via beta1 integrin signals. J Biol Chem 287(34): 28586-28597.
  11. Senga, K., Mostov, K. E., Mitaka, T., Miyajima, A. and Tanimizu, N. (2012). Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell 23(15): 2845-2855.
  12. Ooe, H., Chen, Q., Kon, J., Sasaki, K., Miyoshi, H., Ichinohe, N., Tanimizu, N. and Mitaka, T. (2012). Proliferation of rat small hepatocytes requires follistatin expression. J Cell Physiol 227(6): 2363-2370.
  13. Ichinohe, N., Kon, J., Sasaki, K., Nakamura, Y., Ooe, H., Tanimizu, N. and Mitaka, T. (2012). Growth ability and repopulation efficiency of transplanted hepatic stem cells, progenitor cells, and mature hepatocytes in retrorsine-treated rat livers. Cell Transplant 21(1): 11-22.
  14. Tanaka, M., Itoh, T., Tanimizu, N. and Miyajima, A. (2011). Liver stem/progenitor cells: their characteristics and regulatory mechanisms. J Biochem 149(3): 231-239.
  15. Tanimizu, N., Miyajima, A. and Mostov, K. E. (2009). Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol Biol Cell 20(9): 2486-2494.
  16. Tanimizu, N., Miyajima, A. and Mostov, K. E. (2007). Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. Mol Biol Cell 18(4): 1472-1479.
  17. Tanimizu, N., Saito, H., Mostov, K. and Miyajima, A. (2004). Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci 117(Pt 26): 6425-6434.
  18. Tanimizu, N., Tsujimura, T., Takahide, K., Kodama, T., Nakamura, K. and Miyajima, A. (2004). Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver. Gene Expr Patterns 5(2): 209-218.
  19. Tanimizu, N. and Miyajima, A. (2004). Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci 117(Pt 15): 3165-3174.
  20. Tanimizu, N., Nishikawa, M., Saito, H., Tsujimura, T. and Miyajima, A. (2003). Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 116(Pt 9): 1775-1786.
  21. Tanimizu, N., Ueno, H. and Hayashi, R. (2002). Replacement of His12 or His119 of bovine pancreatic ribonuclease A with acidic amino acid residues for the modification of activity and stability. J Biosci Bioeng 94(1): 39-44.
  22. Tanimizu, N., Ueno, H. and Hayashi, R. (1998). Role of Phe120 in the activity and structure of bovine pancreatic ribonuclease A. J Biochem 124(2): 410-416.
Protocols by Naoki Tanimizu
  1. Clonal Culture of Mouse Liver Progenitor Cells