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Michael A. Helmrath


M.D. in Medicine, University of Cincinnati College of Medicine,Cincinnati, OH,1993

Current position

Professor of Pediatric and Thoracic Surgery, Cincinnati Children’s Hospital, Cincinnati, OH (2010-present)

Publications (since 2010)

  1. Xanthakos, S. A., Jenkins, T. M., Kleiner, D. E., Boyce, T. W., Mourya, R., Karns, R., Brandt, M. L., Harmon, C. M., Helmrath, M. A., Michalsky, M. P., Courcoulas, A. P., Zeller, M. H., Inge, T. H. and Teen, L. C. (2015). High Prevalence of Nonalcoholic Fatty Liver Disease in Adolescents Undergoing Bariatric Surgery. Gastroenterology 149(3): 623-634 e628.
  2. McGrath, P. S., Watson, C. L., Ingram, C., Helmrath, M. A. and Wells, J. M. (2015). The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas. Diabetes 64(7): 2497-2505.
  3. Van Landeghem, L., Santoro, M. A., Mah, A. T., Krebs, A. E., Dehmer, J. J., McNaughton, K. K., Helmrath, M. A., Magness, S. T. and Lund, P. K. (2015). IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J 29(7): 2828-2842.
  4. Finkbeiner, S. R., Hill, D. R., Altheim, C. H., Dedhia, P. H., Taylor, M. J., Tsai, Y. H., Chin, A. M., Mahe, M. M., Watson, C. L., Freeman, J. J., Nattiv, R., Thomson, M., Klein, O. D., Shroyer, N. F., Helmrath, M. A., Teitelbaum, D. H., Dempsey, P. J. and Spence, J. R. (2015). Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports.
  5. Bout-Tabaku, S., Michalsky, M. P., Jenkins, T. M., Baughcum, A., Zeller, M. H., Brandt, M. L., Courcoulas, A., Buncher, R., Helmrath, M., Harmon, C. M., Chen, M. K. and Inge, T. H. (2015). Musculoskeletal Pain, Self-reported Physical Function, and Quality of Life in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Cohort. JAMA Pediatr 169(6): 552-559.
  6. Michalsky, M. P., Inge, T. H., Simmons, M., Jenkins, T. M., Buncher, R., Helmrath, M., Brandt, M. L., Harmon, C. M., Courcoulas, A., Chen, M., Horlick, M., Daniels, S. R., Urbina, E. M. and Teen, L. C. (2015). Cardiovascular Risk Factors in Severely Obese Adolescents: The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study. JAMA Pediatr 169(5): 438-444.
  7. Mahe, M. M., Sundaram, N., Watson, C. L., Shroyer, N. F. and Helmrath, M. A. (2015). Establishment of human epithelial enteroids and colonoids from whole tissue and biopsy. J Vis Exp(97).
  8. Zeller, M. H., Inge, T. H., Modi, A. C., Jenkins, T. M., Michalsky, M. P., Helmrath, M., Courcoulas, A., Harmon, C. M., Rofey, D., Baughcum, A., Austin, H., Price, K., Xanthakos, S. A., Brandt, M. L., Horlick, M., Buncher, R. and Teen Longitudinal Assessment of Bariatric Surgery, C. (2015). Severe obesity and comorbid condition impact on the weight-related quality of life of the adolescent patient. J Pediatr 166(3): 651-659 e654.
  9. Gilbert, S., Nivarthi, H., Mayhew, C. N., Lo, Y. H., Noah, T. K., Vallance, J., Rulicke, T., Muller, M., Jegga, A. G., Tang, W., Zhang, D., Helmrath, M., Shroyer, N., Moriggl, R. and Han, X. (2015). Activated STAT5 confers resistance to intestinal injury by increasing intestinal stem cell proliferation and regeneration. Stem Cell Reports 4(2): 209-225.
  10. Bertaux-Skeirik, N., Feng, R., Schumacher, M. A., Li, J., Mahe, M. M., Engevik, A. C., Javier, J. E., Peek, R. M., Jr., Ottemann, K., Orian-Rousseau, V., Boivin, G. P., Helmrath, M. A. and Zavros, Y. (2015). CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog 11(2): e1004663.
  11. Inge, T. H., Boyce, T. W., Lee, M., Kollar, L., Jenkins, T. M., Brandt, M. L., Helmrath, M., Xanthakos, S. A., Zeller, M. H., Harmon, C. M., Courcoulas, A. and Michalsky, M. P. (2014). Access to care for adolescents seeking weight loss surgery. Obesity (Silver Spring) 22(12): 2593-2597.
  12. Xiao, N., Jenkins, T. M., Nehus, E., Inge, T. H., Michalsky, M. P., Harmon, C. M., Helmrath, M. A., Brandt, M. L., Courcoulas, A., Moxey-Mims, M., Mitsnefes, M. M. and Teen, L. C. (2014). Kidney function in severely obese adolescents undergoing bariatric surgery. Obesity (Silver Spring) 22(11): 2319-2325.
  13. Watson, C. L., Mahe, M. M., Munera, J., Howell, J. C., Sundaram, N., Poling, H. M., Schweitzer, J. I., Vallance, J. E., Mayhew, C. N., Sun, Y., Grabowski, G., Finkbeiner, S. R., Spence, J. R., Shroyer, N. F., Wells, J. M. and Helmrath, M. A. (2014). An in vivo model of human small intestine using pluripotent stem cells. Nat Med 20(11): 1310-1314.
  14. Li, Y., Fallon, S. C., Helmrath, M. A., Gilger, M. and Brandt, M. L. (2014). Surgical treatment of infantile achalasia: a case report and literature review. Pediatr Surg Int 30(6): 677-679.
  15. Michalsky, M. P., Inge, T. H., Teich, S., Eneli, I., Miller, R., Brandt, M. L., Helmrath, M., Harmon, C. M., Zeller, M. H., Jenkins, T. M., Courcoulas, A., Buncher, R. C. and Teen, L. C. (2014). Adolescent bariatric surgery program characteristics: the Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study experience. Semin Pediatr Surg 23(1): 5-10.
  16. Inge, T. H., Zeller, M. H., Jenkins, T. M., Helmrath, M., Brandt, M. L., Michalsky, M. P., Harmon, C. M., Courcoulas, A., Horlick, M., Xanthakos, S. A., Dolan, L., Mitsnefes, M., Barnett, S. J., Buncher, R. and Teen, L. C. (2014). Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study. JAMA Pediatr 168(1): 47-53.
  17. Mahe, M. M., Aihara, E., Schumacher, M. A., Zavros, Y., Montrose, M. H., Helmrath, M. A., Sato, T. and Shroyer, N. F. (2013). Establishment of Gastrointestinal Epithelial Organoids. Curr Protoc Mouse Biol 3(4): 217-240.
  18. Ubesie, A. C., Kocoshis, S. A., Mezoff, A. G., Henderson, C. J., Helmrath, M. A. and Cole, C. R. (2013). Multiple micronutrient deficiencies among patients with intestinal failure during and after transition to enteral nutrition. J Pediatr 163(6): 1692-1696.
  19. Eradi, B., Hamrick, M., Bischoff, A., Frischer, J. S., Helmrath, M., Hall, J., Pena, A. and Levitt, M. A. (2013). The role of a colon resection in combination with a Malone appendicostomy as part of a bowel management program for the treatment of fecal incontinence. J Pediatr Surg 48(11): 2296-2300.
  20. Fuller, M. K., Faulk, D. M., Sundaram, N., Mahe, M. M., Stout, K. M., von Furstenberg, R. J., Smith, B. J., McNaughton, K. K., Shroyer, N. F., Helmrath, M. A. and Henning, S. J. (2013). Intestinal stem cells remain viable after prolonged tissue storage. Cell Tissue Res 354(2): 441-450.
  21. Wang, F., Scoville, D., He, X. C., Mahe, M. M., Box, A., Perry, J. M., Smith, N. R., Lei, N. Y., Davies, P. S., Fuller, M. K., Haug, J. S., McClain, M., Gracz, A. D., Ding, S., Stelzner, M., Dunn, J. C., Magness, S. T., Wong, M. H., Martin, M. G., Helmrath, M. and Li, L. (2013). Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology 145(2): 383-395 e381-321.
  22. Devine, A. A., Gonzalez, A., Speck, K. E., Knight, R., Helmrath, M., Lund, P. K. and Azcarate-Peril, M. A. (2013). Impact of ileocecal resection and concomitant antibiotics on the microbiome of the murine jejunum and colon. PLoS One 8(8): e73140.
  23. Fuller, M. K., Faulk, D. M., Sundaram, N., Shroyer, N. F., Henning, S. J. and Helmrath, M. A. (2012). Intestinal crypts reproducibly expand in culture. J Surg Res 178(1): 48-54.
  24. Stelzner, M., Helmrath, M., Dunn, J. C., Henning, S. J., Houchen, C. W., Kuo, C., Lynch, J., Li, L., Magness, S. T., Martin, M. G., Wong, M. H., Yu, J. and Consortium, N. I. H. I. S. C. (2012). A nomenclature for intestinal in vitro cultures. Am J Physiol Gastrointest Liver Physiol 302(12): G1359-1363.
  25. Van Landeghem, L., Blue, R. E., Dehmer, J. J., Henning, S. J., Helmrath, M. A. and Lund, P. K. (2012). Localized intestinal radiation and liquid diet enhance survival and permit evaluation of long-term intestinal responses to high dose radiation in mice. PLoS One 7(12): e51310.
  26. Speck, K. E., Garrison, A. P., Rigby, R. J., von Allmen, D. C., Lund, P. K. and Helmrath, M. A. (2011). Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice. J Surg Res 168(1): 62-69.
  27. Hamrick, M., Helmrath, M., Bischoff, A., Eradi, B., Levitt, M. and Pena, A. (2011). Letter to the Editor regarding comparison of anorectal angle and continence after Georgeson and Pena procedures for high/intermediate imperforate anus. J Pediatr Surg 46(5): 1019-1020; author reply 1018-1019.
  28. Dehmer, J. J., Fuller, M. K. and Helmrath, M. A. (2011). Management of pediatric intestinal failure. Adv Pediatr 58(1): 181-194.
  29. Dehmer, J. J., Garrison, A. P., Speck, K. E., Dekaney, C. M., Van Landeghem, L., Sun, X., Henning, S. J. and Helmrath, M. A. (2011). Expansion of intestinal epithelial stem cells during murine development. PLoS One 6(11): e27070.
  30. Kimple, R. J., Wallen, K. E., Person, T., Erwin, R. N., Helmrath, M. A., Gold, S. and Morris, D. E. (2011). First use of electromagnetic setup and real-time tracking in a pediatric patient with vaginal rhabdomyosarcoma. Pract Radiat Oncol 1(1): 47-51.
  31. Inge, T., Helmrath, M. and Vierra, M. (2010). The Santoro III massive enterectomy: how can we justify the risks in obese adolescents? Obes Surg 20(12): 1718-1719.
  32. Brandt, M. L., Harmon, C. M., Helmrath, M. A., Inge, T. H., McKay, S. V. and Michalsky, M. P. (2010). Morbid obesity in pediatric diabetes mellitus: surgical options and outcomes. Nat Rev Endocrinol 6(11): 637-645.
Protocols by Michael A. Helmrath
  1. In vivo Fluorescein Isothiocyanate-dextran (FD4) Permeability Assay
  2. Intravenous Tomato Lectin Injection to Assess Functional Vasculature