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Richard T Wyatt


Ph.D., Sackler School of Graduate Biomedical Sciences, Tufts University of Medicine, 1991

Current position

Professor in Immunology, Department of Immunology and Microbial Science and Senior Director in Viral Immunology, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA


  1. Sharma, S. K., de Val, N., Bale, S., Guenaga, J., Tran, K., Feng, Y., Dubrovskaya, V., Ward, A. B. and Wyatt, R. T. (2015). Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine design. Cell Rep 11(4): 539-550.
  2. Guenaga, J., de Val, N., Tran, K., Feng, Y., Satchwell, K., Ward, A. B. and Wyatt, R. T. (2015). Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties. PLoS Pathog 11(1): e1004570.
  3. Correia, B. E., Bates, J. T., Loomis, R. J., Baneyx, G., Carrico, C., Jardine, J. G., Rupert, P., Correnti, C., Kalyuzhniy, O., Vittal, V., Connell, M. J., Stevens, E., Schroeter, A., Chen, M., Macpherson, S., Serra, A. M., Adachi, Y., Holmes, M. A., Li, Y., Klevit, R. E., Graham, B. S., Wyatt, R. T., Baker, D., Strong, R. K., Crowe, J. E., Jr., Johnson, P. R. and Schief, W. R. (2014). Proof of principle for epitope-focused vaccine design. Nature 507(7491): 201-206.
  4. Tran, K., Poulsen, C., Guenaga, J., de Val, N., Wilson, R., Sundling, C., Li, Y., Stanfield, R. L., Wilson, I. A., Ward, A. B., Karlsson Hedestam, G. B. and Wyatt, R. T. (2014). Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign. Proc Natl Acad Sci U S A 111(7): E738-747.
  5. Sundling, C., Zhang, Z., Phad, G. E., Sheng, Z., Wang, Y., Mascola, J. R., Li, Y., Wyatt, R. T., Shapiro, L. and Karlsson Hedestam, G. B. (2014). Single-cell and deep sequencing of IgG-switched macaque B cells reveal a diverse Ig repertoire following immunization. J Immunol 192(8): 3637-3644.
  6. Madani, N., Princiotto, A. M., Schon, A., LaLonde, J., Feng, Y., Freire, E., Park, J., Courter, J. R., Jones, D. M., Robinson, J., Liao, H. X., Moody, M. A., Permar, S., Haynes, B., Smith, A. B., 3rd, Wyatt, R. and Sodroski, J. (2014). CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol 88(12): 6542-6555.
  7. Chakrabarti, B. K., Feng, Y., Sharma, S. K., McKee, K., Karlsson Hedestam, G. B., Labranche, C. C., Montefiori, D. C., Mascola, J. R. and Wyatt, R. T. (2013). Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates. J Virol 87(24): 13239-13251.
  8. Burton, D. R., Ahmed, R., Barouch, D. H., Butera, S. T., Crotty, S., Godzik, A., Kaufmann, D. E., McElrath, M. J., Nussenzweig, M. C., Pulendran, B., Scanlan, C. N., Schief, W. R., Silvestri, G., Streeck, H., Walker, B. D., Walker, L. M., Ward, A. B., Wilson, I. A. and Wyatt, R. (2012). A Blueprint for HIV Vaccine Discovery. Cell Host Microbe 12(4): 396-407.
  9. Li, Y., O'Dell, S., Wilson, R., Wu, X., Schmidt, S. D., Hogerkorp, C. M., Louder, M. K., Longo, N. S., Poulsen, C., Guenaga, J., Chakrabarti, B. K., Doria-Rose, N., Roederer, M., Connors, M., Mascola, J. R. and Wyatt, R. T. (2012). HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins. J Virol 86(20): 11231-11241.
  10. Sundling, C., Li, Y., Huynh, N., Poulsen, C., Wilson, R., O'Dell, S., Feng, Y., Mascola, J. R., Wyatt, R. T.* and Karlsson Hedestam, G. B. (2012). High-resolution definition of vaccine-elicited B cell responses against the HIV primary receptor binding site. Sci Transl Med 4(142): 142ra196. (*co-corresponding)
  11. Feng, Y., McKee, K., Tran, K., O'Dell, S., Schmidt, S. D., Phogat, A., Forsell, M. N., Karlsson Hedestam, G. B., Mascola, J. R. and Wyatt, R. T. (2012). Biochemically defined HIV-1 envelope glycoprotein variant immunogens display differential binding and neutralizing specificities to the CD4-binding site. J Biol Chem 287(8): 5673-5686.
  12. Li, Y., O'Dell, S., Walker, L. M., Wu, X., Guenaga, J., Feng, Y., Schmidt, S. D., McKee, K., Louder, M. K., Ledgerwood, J. E., Graham, B. S., Haynes, B. F., Burton, D. R., Wyatt, R. T.* and Mascola, J. R. (2011). Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. J Virol 85(17): 8954-8967. (*co-corresponding)
  13. Li, Y., Svehla, K., Louder, M. K., Wycuff, D., Phogat, S., Tang, M., Migueles, S. A., Wu, X., Phogat, A., Shaw, G. M., Connors, M., Hoxie, J., Mascola, J. R. and Wyatt, R. (2009). Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individuals. J Virol 83(2): 1045-1059.
  14. Dey, B., Svehla, K., Xu, L., Wycuff, D., Zhou, T., Voss, G., Phogat, A., Chakrabarti ,B. K., Li, Y., Shaw, G., Kwong, P. D., Nabel, G., Mascola, J. and Wyatt, R. (2009). Structure-based Modification of HIV-1 gp120 Dramatically Enhances Conformational Stabilization and Host Immune Responses to a Discontinuous Epitope. PLoS Pathog.
  15. Forsell, M. N., Dey, B., Morner, A., Svehla, K., O'Dell, S., Hogerkorp, C. M., Voss, G., Thorstensson, R., Shaw, G. M., Mascola, J. R., Karlsson Hedestam, G. B. and Wyatt, R. T. (2008). B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4. PLoS Pathog 4(10): e1000171.
Protocols by Richard T Wyatt
  1. Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays
  2. Kinetic Analysis of Monoclonal Antibody Binding to HIV-1 gp120-derived Hyperglycosylated Cores