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Debbie van Baarle


Ph.D. in Immunology, University of Amsterdam, 2000

Current position

Head of the Department Immune Mechanisms of the Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM) (since 2013)

Publications (selected from 119)

  1. Schellens, I. M., Hoof, I., Meiring, H. D., Spijkers, S. N., Poelen, M. C., van Gaans-van den Brink, J. A., van der Poel, K., Costa, A. I., van Els, C. A., van Baarle, D. and Kesmir, C. (2015). Comprehensive Analysis of the Naturally Processed Peptide Repertoire: Differences between HLA-A and B in the Immunopeptidome. PLoS One 10(9): e0136417.
  2. Costa, A. I., Koning, D., Ladell, K., McLaren, J. E., Grady, B. P., Schellens, I. M., van Ham, P., Nijhuis, M., Borghans, J. A., Kesmir, C., Price, D. A. and van Baarle, D. (2015). Complex T-cell receptor repertoire dynamics underlie the CD8+ T-cell response to HIV-1. J Virol 89(1): 110-119.
  3. Schellens, I. M., Spits, H. B., Navis, M., Westerlaken, G. H., Nanlohy, N. M., Coffeng, L. E., Kootstra, N., Miedema, F., Schuitemaker, H., Borghans, J. A. and van Baarle, D. (2014). Differential characteristics of cytotoxic T lymphocytes restricted by the protective HLA alleles B*27 and B*57 in HIV-1 infection. J Acquir Immune Defic Syndr 67(3): 236-245.
  4. Rosendahl Huber, S., van Beek, J., de Jonge, J., Luytjes, W. and van Baarle, D. (2014). T cell responses to viral infections - opportunities for Peptide vaccination. Front Immunol 5: 171.
  5. Koning, D., Costa, A. I., Hoof, I., Miles, J. J., Nanlohy, N. M., Ladell, K., Matthews, K. K., Venturi, V., Schellens, I. M., Borghans, J. A., Kesmir, C., Price, D. A. and van Baarle, D. (2013). CD8+ TCR repertoire formation is guided primarily by the peptide component of the antigenic complex. J Immunol 190(3): 931-939.
  6. Pietersma, F. L., van Dorp, S., Jacobi, R., Ran, L., Nanlohy, N. M., Schuurman, R., Minnema, M. C., Meijer, E. and van Baarle, D. (2010). High level of perforin expression in T cells: An early prognostic marker of the severity of herpesvirus reactivation after allogeneic stem cell transplantation in adults. Clin Infect Dis 50(5): 717-725.
  7. van Baarle, D., Nanlohy, N. M., Otto, S., Plunkett, F. J., Fletcher, J. M. and Akbar, A. N. (2008). Progressive telomere shortening of Epstein-Barr virus-specific memory T cells during HIV infection: contributor to exhaustion? J Infect Dis 198(9): 1353-1357.
  8. Piriou, E., van Dort, K., Nanlohy, N. M., van Oers, M. H., Miedema, F. and van Baarle, D. (2005). Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma. Blood 106(9): 3166-3174.
  9. van Baarle, D., Kostense, S., van Oers, M. H., Hamann, D. and Miedema, F. (2002). Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue. Trends Immunol 23(12): 586-591.
  10. Migueles, S. A., Laborico, A. C., Shupert, W. L., Sabbaghian, M. S., Rabin, R., Hallahan, C. W., Van Baarle, D., Kostense, S., Miedema, F., McLaughlin, M., Ehler, L., Metcalf, J., Liu, S. and Connors, M. (2002). HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 3(11): 1061-1068.
  11. van Baarle, D., Hovenkamp, E., Callan, M. F., Wolthers, K. C., Kostense, S., Tan, L. C., Niesters, H. G., Osterhaus, A. D., McMichael, A. J., van Oers, M. H. and Miedema, F. (2001). Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood 98(1): 146-155.
Protocols by Debbie van Baarle
  1. TCRβ Clonotype Analysis of EBV and CMV-Specific Human CD8+ T Cells