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Kenneth W. Bayles


Ph.D. in Microbiology, Kansas State University, 1989

Current position

Associate Vice Chancellor for Basic Science Research, University of Nebraska Medical Center (07/2011-present)
Adjunct Associate Professor, Division of Basic Biomedical Sciences, Sanford School of Medicine of The University of South Dakota (07/2007-present)
Professor and Vice Chair for Research, Department of Pathology & Microbiology, University of Nebraska Medical Center (07/2007-present)

Publications (since 2010)

  1. Lehman, M. K., Bose, J. L., Sharma-Kuinkel, B. K., Moormeier, D. E., Endres, J. L., Sadykov, M. R., Biswas, I. and Bayles, K. W. (2015). Identification of the amino acids essential for LytSR-mediated signal transduction in Staphylococcus aureus and their roles in biofilm-specific gene expression. Mol Microbiol 95(4): 723-737.( Epub ahead of print)
  2. Moormeier, D. E., Bose, J. L., Horswill, A. R. and Bayles, K. W. (2014). Temporal and stochastic control of Staphylococcus aureus biofilm development. MBio 5(5): e01341-01314.
  3. Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. and Wang, D. (2014). The development of drug-free therapy for prevention of dental caries. Pharm Res 31(11): 3031-3037.( Epub ahead of print)
  4. Thomas, V. C., Sadykov, M. R., Chaudhari, S. S., Jones, J., Endres, J. L., Widhelm, T. J., Ahn, J. S., Jawa, R. S., Zimmerman, M. C. and Bayles, K. W. (2014). A central role for carbon-overflow pathways in the modulation of bacterial cell death. PLoS Pathog 10(6): e1004205.
  5. Laabei, M., Recker, M., Rudkin, J. K., Aldeljawi, M., Gulay, Z., Sloan, T. J., Williams, P., Endres, J. L., Bayles, K. W., Fey, P. D., Yajjala, V. K., Widhelm, T., Hawkins, E., Lewis, K., Parfett, S., Scowen, L., Peacock, S. J., Holden, M., Wilson, D., Read, T. D., van den Elsen, J., Priest, N. K., Feil, E. J., Hurst, L. D., Josefsson, E. and Massey, R. C. (2014). Predicting the virulence of MRSA from its genome sequence. Genome Res 24(5): 839-849.
  6. Abdelhady, W., Bayer, A. S., Seidl, K., Moormeier, D. E., Bayles, K. W., Cheung, A., Yeaman, M. R. and Xiong, Y. Q. (2014). Impact of vancomycin on sarA-mediated biofilm formation: role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis 209(8): 1231-1240.
  7. Bose, J. L., Daly, S. M., Hall, P. R. and Bayles, K. W. (2014). Identification of the Staphylococcus aureus vfrAB operon, a novel virulence factor regulatory locus. Infect Immun 82(5): 1813-1822.
  8. Bayles, K. W. (2014). Bacterial programmed cell death: making sense of a paradox. Nat Rev Microbiol 12(1): 63-69.
  9. Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. and Wang, D. (2013). The development of dentotropic micelles with biodegradable tooth-binding moieties. Pharm Res 30(11): 2808-2817.
  10. Thomas, V. C., Kinkead, L. C., Janssen, A., Schaeffer, C. R., Woods, K. M., Lindgren, J. K., Peaster, J. M., Chaudhari, S. S., Sadykov, M., Jones, J., AbdelGhani, S. M., Zimmerman, M. C., Bayles, K. W., Somerville, G. A. and Fey, P. D. (2013). A dysfunctional tricarboxylic acid cycle enhances fitness of Staphylococcus epidermidis during beta-lactam stress. MBio 4(4).
  11. Gries, C. M., Bose, J. L., Nuxoll, A. S., Fey, P. D. and Bayles, K. W. (2013). The Ktr potassium transport system in Staphylococcus aureus and its role in cell physiology, antimicrobial resistance and pathogenesis. Mol Microbiol 89(4): 760-773.
  12. Yang, S. J., Xiong, Y. Q., Yeaman, M. R., Bayles, K. W., Abdelhady, W. and Bayer, A. S. (2013). Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus. Antimicrob Agents Chemother 57(8): 3875-3882.
  13. Sadykov, M. R., Thomas, V. C., Marshall, D. D., Wenstrom, C. J., Moormeier, D. E., Widhelm, T. J., Nuxoll, A. S., Powers, R. and Bayles, K. W. (2013). Inactivation of the Pta-AckA pathway causes cell death in Staphylococcus aureus. J Bacteriol 195(13): 3035-3044.
  14. Moormeier, D. E., Endres, J. L., Mann, E. E., Sadykov, M. R., Horswill, A. R., Rice, K. C., Fey, P. D. and Bayles, K. W. (2013). Use of microfluidic technology to analyze gene expression during Staphylococcus aureus biofilm formation reveals distinct physiological niches. Appl Environ Microbiol 79(11): 3413-3424.
  15. Bose, J. L., Fey, P. D. and Bayles, K. W. (2013). Genetic tools to enhance the study of gene function and regulation in Staphylococcus aureus. Appl Environ Microbiol 79(7): 2218-2224.
  16. Fey, P. D., Endres, J. L., Yajjala, V. K., Widhelm, T. J., Boissy, R. J., Bose, J. L. and Bayles, K. W. (2013). A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes. MBio 4(1): e00537-00512.
  17. Wang, J. and Bayles, K. W. (2013). Programmed cell death in plants: lessons from bacteria? Trends Plant Sci 18(3): 133-139.
  18. Nuxoll, A. S., Halouska, S. M., Sadykov, M. R., Hanke, M. L., Bayles, K. W., Kielian, T., Powers, R. and Fey, P. D. (2012). CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism. PLoS Pathog 8(11): e1003033.
  19. Liu, X. M., Zhang, Y., Chen, F., Khutsishvili, I., Fehringer, E. V., Marky, L. A., Bayles, K. W. and Wang, D. (2012). Prevention of orthopedic device-associated osteomyelitis using oxacillin-containing biomineral-binding liposomes. Pharm Res 29(11): 3169-3179.
  20. Bose, J. L., Lehman, M. K., Fey, P. D. and Bayles, K. W. (2012). Contribution of the Staphylococcus aureus Atl AM and GL murein hydrolase activities in cell division, autolysis, and biofilm formation. PLoS One 7(7): e42244.
  21. Kaplan, J. B., Izano, E. A., Gopal, P., Karwacki, M. T., Kim, S., Bose, J. L., Bayles, K. W. and Horswill, A. R. (2012). Low levels of beta-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. MBio 3(4): e00198-00112.
  22. Sadykov, M. R. and Bayles, K. W. (2012). The control of death and lysis in staphylococcal biofilms: a coordination of physiological signals. Curr Opin Microbiol 15(2): 211-215.
  23. Wang, G., Epand, R. F., Mishra, B., Lushnikova, T., Thomas, V. C., Bayles, K. W. and Epand, R. M. (2012). Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37. Antimicrob Agents Chemother 56(2): 845-856.
  24. Shearer, J. E., Wireman, J., Hostetler, J., Forberger, H., Borman, J., Gill, J., Sanchez, S., Mankin, A., LaMarre, J. and Lindsay, J. A. (2011). Major families of multiresistant plasmids from geographically and epidemiologically diverse staphylococci. G3: Genes, Genomes, Genetics 1(7): 581-591.
  25. Kiedrowski, M. R., Kavanaugh, J. S., Malone, C. L., Mootz, J. M., Voyich, J. M., Smeltzer, M. S., Bayles, K. W. and Horswill, A. R. (2011). Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One 6(11): e26714.
  26. Pang, X., Moussa, S. H., Targy, N. M., Bose, J. L., George, N. M., Gries, C., Lopez, H., Zhang, L., Bayles, K. W., Young, R. and Luo, X. (2011). Active Bax and Bak are functional holins. Genes Dev 25(21): 2278-2290.
  27. Thurlow, L. R., Hanke, M. L., Fritz, T., Angle, A., Aldrich, A., Williams, S. H., Engebretsen, I. L., Bayles, K. W., Horswill, A. R. and Kielian, T. (2011). Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. J Immunol 186(11): 6585-6596.
  28. Ranjit, D. K., Endres, J. L. and Bayles, K. W. (2011). Staphylococcus aureus CidA and LrgA proteins exhibit holin-like properties. J Bacteriol 193(10): 2468-2476.
  29. Ahn, S. J., Rice, K. C., Oleas, J., Bayles, K. W. and Burne, R. A. (2010). The Streptococcus mutans Cid and Lrg systems modulate virulence traits in response to multiple environmental signals. Microbiology 156(Pt 10): 3136-3147.
  30. Chen, F., Rice, K. C., Liu, X. M., Reinhardt, R. A., Bayles, K. W. and Wang, D. (2010). Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm. Pharm Res 27(11): 2356-2364.
  31. Huseby, M. J., Kruse, A. C., Digre, J., Kohler, P. L., Vocke, J. A., Mann, E. E., Bayles, K. W., Bohach, G. A., Schlievert, P. M., Ohlendorf, D. H. and Earhart, C. A. (2010). Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms. Proc Natl Acad Sci U S A 107(32): 14407-14412.
  32. Beenken, K. E., Mrak, L. N., Griffin, L. M., Zielinska, A. K., Shaw, L. N., Rice, K. C., Horswill, A. R., Bayles, K. W. and Smeltzer, M. S. (2010). Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS One 5(5): e10790.
Protocols by Kenneth W. Bayles
  1. Electron Paramagnetic Resonance (EPR) Spectroscopy to Detect Reactive Oxygen Species in Staphylococcus aureus