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Sonsoles Hortelano


Ph.D. in Biochemistry, Deparment of Biochemistry, University Complutense of Madrid, 1996

Current position

Head of Pharmacology Therapies Unit, Research institute for Rare diseases (IIER), Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid

Publications (since 2005)

  1. Mota, A., Jimenez-Garcia, L., Herranz, S., de Las Heras, B. and Hortelano, S. (2015). alpha-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation. Toxicol Appl Pharmacol 286(3): 168-177.
  2. Valenzuela-Barra, G., Castro, C., Figueroa, C., Barriga, A., Silva, X., de Las Heras, B., Hortelano, S. and Delporte, C. (2015). Anti-inflammatory activity and phenolic profile of propolis from two locations in Region Metropolitana de Santiago, Chile. J Ethnopharmacol 168: 37-44.
  3. Jimenez-Garcia, L., Herranz, S., Luque, A. and Hortelano, S. (2015). Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages. Eur J Immunol 45(1): 273-286.
  4. Gomez, A. M., Martinez, C., Gonzalez, M., Luque, A., Melen, G. J., Martinez, J., Hortelano, S., Lassaletta, A., Madero, L. and Ramirez, M. (2015). Chemokines and relapses in childhood acute lymphoblastic leukemia: A role in migration and in resistance to antileukemic drugs. Blood Cells Mol Dis 55(3): 220-227.
  5. Oramas-Royo, S., Torrejon, C., Cuadrado, I., Hernandez-Molina, R., Hortelano, S., Estevez-Braun, A. and de Las Heras, B. (2013). Synthesis and cytotoxic activity of metallic complexes of lawsone. Bioorg Med Chem 21(9): 2471-2477.
  6. Garaulet, G., Alfranca, A., Torrente, M., Escolano, A., Lopez-Fontal, R., Hortelano, S., Redondo, J. M. and Rodriguez, A. (2013). IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis. Mol Ther 21(1): 119-130.
  7. Traves, P. G., Lopez-Fontal, R., Cuadrado, I., Luque, A., Bosca, L., de las Heras, B. and Hortelano, S. (2013). Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Oncogene 32(2): 259-268.
  8. Traves, P. G., Luque, A. and Hortelano, S. (2012). Macrophages, inflammation, and tumor suppressors: ARF, a new player in the game. Mediators Inflamm 2012: 568783.
  9. Herranz, S., Traves, P. G., Luque, A. and Hortelano, S. (2012). Role of the tumor suppressor ARF in macrophage polarization: Enhancement of the M2 phenotype in ARF-deficient mice. Oncoimmunology 1(8): 1227-1238.
  10. Traves, P. G., Luque, A. and Hortelano, S. (2012). Tumor suppressor ARF: The new player of innate immunity. Oncoimmunology 1(6): 946-947.
  11. Cuadrado, I., Cidre, F., Herranz, S., Estevez-Braun, A., de las Heras, B. and Hortelano, S. (2012). Labdanolic acid methyl ester (LAME) exerts anti-inflammatory effects through inhibition of TAK-1 activation. Toxicol Appl Pharmacol 258(1): 109-117.
  12. Traves, P. G., Lopez-Fontal, R., Luque, A. and Hortelano, S. (2011). The tumor suppressor ARF regulates innate immune responses in mice. J Immunol 187(12): 6527-6538.
  13. Hueso-Falcon, I., Cuadrado, I., Cidre, F., Amaro-Luis, J. M., Ravelo, A. G., Estevez-Braun, A., de Las Heras, B. and Hortelano, S. (2011). Synthesis and anti-inflammatory activity of ent-kaurene derivatives. Eur J Med Chem 46(4): 1291-1305.
  14. Giron, N., Perez-Sacau, E., Lopez-Fontal, R., Amaro-Luis, J. M., Hortelano, S., Estevez-Braun, A. and de Las Heras, B. (2010). Evaluation of labdane derivatives as potential anti-inflammatory agents. Eur J Med Chem 45(7): 3155-3161.
  15. Hortelano, S., Lopez-Fontal, R., Traves, P. G., Villa, N., Grashoff, C., Bosca, L. and Luque, A. (2010). ILK mediates LPS-induced vascular adhesion receptor expression and subsequent leucocyte trans-endothelial migration. Cardiovasc Res 86(2): 283-292.
  16. Hueso-Falcon, I., Giron, N., Velasco, P., Amaro-Luis, J. M., Ravelo, A. G., de las Heras, B., Hortelano, S. and Estevez-Braun, A. (2010). Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives. Bioorg Med Chem 18(4): 1724-1735.
  17. Lopez-Fontal, R., Zeini, M., Traves, P. G., Gomez-Ferreria, M., Aranda, A., Saez, G. T., Cerda, C., Martin-Sanz, P., Hortelano, S. and Bosca, L. (2010). Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy. PLoS One 5(1): e8710.
  18. de las Heras, B. and Hortelano, S. (2009). Molecular basis of the anti-inflammatory effects of terpenoids. Inflamm Allergy Drug Targets 8(1): 28-39.
  19. Diaz-Viciedo, R., Hortelano, S., Giron, N., Masso, J. M., Rodriguez, B., Villar, A. and de Las Heras, B. (2008). Modulation of inflammatory responses by diterpene acids from Helianthus annuus L. Biochem Biophys Res Commun 369(2): 761-766.
  20. Giron, N., Traves, P. G., Rodriguez, B., Lopez-Fontal, R., Bosca, L., Hortelano, S. and de las Heras, B. (2008). Suppression of inflammatory responses by labdane-type diterpenoids. Toxicol Appl Pharmacol 228(2): 179-189.
  21. Zeini, M., Lopez-Fontal, R., Traves, P. G., Benito, G. and Hortelano, S. (2007). Differential sensitivity to apoptosis among the cells that contribute to the atherosclerotic disease. Biochem Biophys Res Commun 363(2): 444-450.
  22. de las Heras, B., Hortelano, S., Giron, N., Bermejo, P., Rodriguez, B. and Bosca, L. (2007). Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages. Br J Pharmacol 152(2): 249-255.
  23. Traves, P. G., Hortelano, S., Zeini, M., Chao, T. H., Lam, T., Neuteboom, S. T., Theodorakis, E. A., Palladino, M. A., Castrillo, A. and Bosca, L. (2007). Selective activation of liver X receptors by acanthoic acid-related diterpenes. Mol Pharmacol 71(6): 1545-1553.
  24. Hortelano, S., Zeini, M., Casado, M., Martin-Sanz, P. and Bosca, L. (2007). Animal models for the study of liver regeneration: role of nitric oxide and prostaglandins. Front Biosci 12: 13-21.
  25. Zeini, M., Traves, P. G., Lopez-Fontal, R., Pantoja, C., Matheu, A., Serrano, M., Bosca, L. and Hortelano, S. (2006). Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis. J Immunol 177(5): 3327-3336.
  26. Martin Sanz, P., Hortelano, S., Bosca, L. and Casado, M. (2006). Cyclooxygenase 2: understanding the pathophysiological role through genetically altered mouse models. Front Biosci 11: 2876-2888.
  27. Hortelano, S., Zeini, M., Traves, P. G. and Bosca, L. (2005). Nitric oxide and cell signaling: in vivo evaluation of NO-dependent apoptosis by MRI and not NMR techniques. Methods Enzymol 396: 579-584.
  28. Zeini, M., Hortelano, S., Traves, P. G., Gomez-Valades, A. G., Pujol, A., Perales, J. C., Bartrons, R. and Bosca, L. (2005). Assessment of a dual regulatory role for NO in liver regeneration after partial hepatectomy: protection against apoptosis and retardation of hepatocyte proliferation. FASEB J 19(8): 995-997.
  29. Bosca, L., Zeini, M., Traves, P. G. and Hortelano, S. (2005). Nitric oxide and cell viability in inflammatory cells: a role for NO in macrophage function and fate. Toxicology 208(2): 249-258.
  30. Chao, T. H., Lam, T., Vong, B. G., Traves, P. G., Hortelano, S., Chowdhury, C., Bahjat, F. R., Lloyd, G. K., Moldawer, L. L., Bosca, L., Palladino, M. A. and Theodorakis, E. A. (2005). A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation. Chembiochem 6(1): 133-144.
Protocols by Sonsoles Hortelano
  1. Chitin-challenged Mice Model to Study M2 Macrophages Polarization
  2. Thioglycollate-elicited Peritoneal Macrophages Preparation and Arginase Activity Measurement in IL-4 Stimulated Macrophages